The level of cyclic adenosine monophosphate (AMP) in duct saliva from the dog submandibular gland was increased after cyclic AMP was administered intravenously in vivo. Isoproterenol increased the level of cyclic AMP in plasma and saliva in vivo and in salivary gland slices in vitro, but increased the level only slightly in saliva in a perfused dog submaxillary gland.
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References
1.
Butcher, R.W. , and Sutherland, E.W.: Adenosine 3',5'-Phosphate in Biological Materials, J Biochem (Tokyo) 237 : 1244-1250, 1962.
2.
Broadus, A.E. ; Hardman, J.G.; Kaminsky, N.I.; Ball, J.H.; Sutherland, E.W.; and Liddle, G.W.: Extracellular Cyclic Nucleotides, Ann NY Acad Sci185: 50-66, 1971.
3.
Broadus, A.E. ; Kaminsky, N.I.; Hardman, J.G.; Sutherland, E.W.; and Liddle, G.W.: Kinetic Parameters and Renal Clearances of Plasma Adenosine 3',5'-Monophosphate and Guanosine 3',5'-Monophosphate in Man, J Clin Invest49: 2222-2236, 1970 .
4.
Wehmann, R.E. ; Blonde, L.; and Steiner, A.L.: Sources of Cyclic Nucleotides in Plasma , J Clin Invest53: 173-179, 1974.
5.
Broadus, A.E. ; Kaminsky, N.I.; Northcutt, R.C.; Hardman, J.G.; Sutherland, E.W.; and Liddle, G.W.: Effects of Glucagon on Adenosine 3',5'-Monophosphate and Guanosine 3',5'-Monophosphate in Human Plasma and Urine, J Clin Invest49: 2237-2245, 1970.
6.
Kaminsky, N.I. ; Broadus, A.E.; Hardman, J.G.; Jones, D.J., JR.; Ball, J.H.; Sutherland, E.W.; and Liddle, G.W.: Effects of Parathyroid Hormone on Plasma and Urinary Adenosine 3',5'-Monophosphate in Man, J Clin Invest49: 2387-2395, 1970.
7.
Schaeffer, L.D. ; Sproles, A.; and Krakowski, A.:Detection of Cyclic AMP in Parotid Saliva of Normal Individuals, J Dent Res52: 629, 1973.
8.
Bresnahan, M. ; Polgar, P.; Wells, H.; and Rutenburg, A.: Adenosine 3',5'-cyclic Monophosphate (CAMP) in Human Saliva, J Dent Res52 (Special Issue) : Abstract No. 262, 1973.
9.
Kanamori, T. ; Kuzuya, H.; and Nagatsu, T.: Excretion of Cyclic GMP and Cyclic AMP into Human Parotid Saliva, J Dent Res53: 760, 1974.
10.
Bdolah, A., and Schramm, M.: The Function of 3',5'-Cyclic AMP in Enzyme Secretion, Biochem Biophys Res Commun18: 452-454, 1965.
11.
Schramm, M. , and Niam, E.: Adenyl Cyclase of Rat Parotid Gland, J Biol Chem245: 3225-3231, 1970.
12.
Bhoola, K.D. , and Lemon, M.J.C.: Studies on the Activation of Adenylate Cyclase from the Submaxillary Gland and Pancreas, J Physiol232: 83-84, 1973.
13.
Monnard, P. , and Schorderet, M.: Cyclic Adenosine 3',5'-Monophosphate Concentration in Rabbit Parotid Slices Following Stimulation by Secretagogues, Eur J Pharmacol23:306-310, 1973.
14.
Kanamori, T. ; Hayakawa, T.; and Nagatsu, T.: Adenosine 3',5'-Monophosphate-Dependent Protein Kinase and Amylase Secretion from Rat Parotid Gland, Biochem Biophys Res Commun57: 394-398, 1974.
15.
Inoue, T.: Studies on Excretory Mechanism of Saliva with Perfused Salivary Gland, J Physiol Soc Jap20: 430-443, 1958.
16.
Weinryb, I.: Protein Binding Assays for Cyclic AMP: Radioimmunoassay and Cyclic AMP-Dependent Protein Kinase Binding Assay, in Chasin, M. (ed) : Methods in Cyclic Nucleotide Research, New York: Marcel Dekker, Inc., 1972 , pp 31-64.
17.
Steiner, A.L. ; Parker, C.W.; and Kipnis, D.M.: Radioimmunoassav for Cvclic Nucleotides , J Biol Chem247: 1106-1113, 1972 .
18.
Weinryb, I.; Michel, I.M.; and Hess, S.M.: Radioimmunoassay of Cyclic AMP without Precipitating Antibody, Anal Biochem45: 659-663, 1972.
19.
Bray, G.A.: A Simple Efficient Liquid Scintillator for Counting Aqueous Solutions in a Liquid Scintillation Counter, Anal Biochem1:279-285, 1960.
20.
Hartree, E.F. : Determination of Protein: A Modification of the Lowry Method That Gives a Linear Photometric Response, Anal Biochem48: 422-427, 1972.
21.
Kaminsky, N.I. ; Ball, J.H.; Broadus, A.E.; Hardman, J.G.; Sutherland, E.W.; and Liddle, G.W.: Hormonal Effects on Extracellular Cyclic Nucleotides in Man, Ann NY Acad Sci185: 235-244, 1971.
