Interactions of chlorhexidine and structurally related biguanides with selected monomolecular-film systems (that is, stearic acid, stearyl alcohol, and N-octadecylacetamide) were explored. The data reflected the significance of ionic associations between the compounds and stearic acid films and, in the instance of the biguanide analogs, indicated that the length of the alkyl chain was an important factor in the penetration process.
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References
1.
Fisher, R.G. ; Quintana, R.P.; and Boul-Ware , M.A.: Surface-Chemical Studies on Chlorhexidine and Related Compounds: I. Effects at Air-Water, n-Hexane-Water, and Hydroxyapatite-Water Interfaces, J Dent Res54: 20-24, 1975.
2.
Quintana, R.P.; Lasslo, A.; Clark, J.W.; and Baier, R.E.: Surface-Chemical Approach to the Prevention of Pathological Accumulations of Dental Deposits, in Lasslo, A., and Quintana, R.P. (eds) : Surface Chemistry and Dental Integuments, Springfield, Ill.: Charles C Thomas, 1973, pp 392-413.
3.
Quintana, R.P.: Surface Chemistry of Dental Integuments, in Baier, R.E. (ed) : Applied Chemistry at Protein Interfaces , Washington, DC: American Chemical Society , in press.
4.
Quintana, R.P.; Lasslo, A.; and Fisher, R.G.: Surface Chemistry in the Study of Biological Systems, in Lasslo, A., and Quintana, R.P. (eds) : Surface Chemistry and Dental Integuments, Springfield, Ill.: Charles C Thomas, 1973, pp 276-336.
5.
Felmeister, A.: Relationships between Surface Activity and Biological Activity of Drugs, J Pharm Sci61: 151-164, 1972.
6.
Quintana, R.P. ; Lasslo, A.; and Ousley, S.L.: Effect of Griseofulvin Upon Lipid Films at the Air-Water Interface, J Pharm Sci56: 1193-1194, 1967.
7.
Quintana, R.P. ; Fisher, R.G.; and Lasslo, A.Prophylactic Agents Effecting Lysis or Dental Plaque. Penetration of Monomolecular Films of Stearyl Alcohol and of N-Octadecylacetamide by N-Dodecylurea and Related Compounds, J Colloid Interface Sci44: 443-447, 1973.
8.
Gaines, G.L., Jr.: Insoluble Monolayers at Liquid-Gas Interfaces, New York : Interscience Publishers, 1966, pp 45-50.
9.
Skou, J.C.: Relation Between the Ability of Various Compounds to Block Nervous Conduction and Their Penetration into a Monomolecular Layer of Nerve-Tissue Lipoids, Biochim Biophys Acta30: 625-629, 1958.
10.
Blois, D.W. , and Swarbrick, J.: Interaction of Quaternary Ammonium Bactericides with Biological Materials II: Insoluble Monolayer Studies, J Pharm Sci61: 393-399, 1972.
11.
Gershfeld, N.L.: Film Penetration and Adsorption. The Effect of Veratrine and Procaine on the Desorption Kinetics of Monolayers of Monoöctadecyl Phosphate, J Phys Chem66: 1923-1927, 1962 .
12.
Vilallonga, F.A.; Garrett, E.R.; and Cerei-Jido , M.: Kinetics and Mechanisms of Monolayer Interactions I: Cetyl Sulfate and Cetrimonium Ions Interacting with Dipalmitoyl Lecithin and Dipalmitoyl Glycerol, J Pharm Sci61: 1720-1727, 1972.
13.
Vilallonga, F.A., and Garrett, E.R.: Kinetics and Mechanisms of Monolayer Interactions II: Effect of Chain Length of Alkyl Ionic Surfactants on Their Interaction with Dipalmitoyl Glycerol, Dipalmitoyl Phosphatidylethanolamine, and Dipalmitoyl Lecithin, J Pharm Sci62: 1605-1609, 1973 .
14.
Bagc, J.; Haber, M.D.; and Gregor, H.P.: Composition of Stearic and Behenic Acid Monolayers from Sodium-Containing Substrates, J Colloid Interface Sci22: 138-143, 1966.
15.
Eley, D.D., and Hedge, D.G.: The Energetics of Lipid-Protein Interactions, J Colloid Sci12: 419-429, 1957.
16.
Draus, F.J. ; Miklos, F.L.; and West, B.: Mucoid Alteration Effects on Synthetic Calculus Formation, Arch Oral Biol11: 521-525, 1966.
17.
Draus, F.J. ; Tarbet, W.J.; and Miklos, F.L.: Salivary Enzymes and Calculus Formation , J Periodont Res3: 232-235, 1968.
