Levels of 5,5-diphenylhydantoin (DPH) and its para-hydroxy metabolite (HPPH) were measured in serum, saliva, and in segments of hyperplastic gingiva from patients receiving chronic drug therapy. The severity of gingival hyperplasia tends to be associated with higher DPH levels in gingiva and with lower tissue levels of HPPH.
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References
1.
Kimball, O.P. : The Treatment of Epilepsy with Sodium Diphenylhydantoinate , JAMA112: 1244-1245, 1939 .
2.
Staple, P.H. : Some Tissue Reactions Associated with 5:5-Diphenylhydantoin ('Dilantin') Sodium Therapy, Br Dent J95 : 289-302, 1953.
3.
Staple, P.H. : The Adrenal Glands and Gingival Hyperplasia Due to Phenytoin Sodium, Lancet2: 600-601, 1953.
4.
Shafer, W.G. : Effect of Dilantin Sodium on Growth of Human Fibroblast-Like Cell Cultures, Proc Soc Exp Biol Med104: 198-201, 1960.
5.
Shapiro, M.: Acceleration of Gingival Wound Healing in Non-Epileptic Patients Receiving Diphenylhydantoin Sodium, Exp Med Surg16: 41-53, 1958.
6.
Babcock, J.R. , and Nelson, G.H.: Gingival Hyperplasia and Dilantin Content of Saliva: A Pilot Study, JADA68: 195-198, 1964.
7.
Gardner, A.F. ; Gross, S.G.; and Wynne, L.E.: An Investigation of Gingival Hyperplasia resulting from Diphenylhydantoin Sodium Therapy in Seventy-seven Mentally-retarded Patients, Exp Med Surg20: 133-158, 1962.
8.
Aas, E.: Hyperplasia Gingivae Diphenylhydantoinea, Boston : Scandinavian University Books, 1963, pp 19-23.
9.
Conard, G.J.: Pharmacological Aspects of Diphenylhydantoin Disposition, PhD thesis , University of Wisconsin, 1970.
10.
Hall, W.B.: Dilantin Hyperplasia: A Preventable Lesion, abstracted, IADR Program and Abstracts of Papers, No. 17, 1969.
11.
Nuki, K., and Cooper, S.: The Role of Inflammation in the Pathogenesis of Gingival Enlargement During the Administration of Diphenylhydantoin Sodium in Cats, J Periodont Res7: 102-110, 1972.
12.
Abadom, P.N. : The Pharmacological Reactions and Metabolism of 5,5-Diphenylhydantoin in the Ferret, MS thesis, University of Rochester, 1959.
13.
Steinberg, A.D.; Alvarez, J.; and Jeffay, H.: Lack of Relationship between the Degree of Induced Gingival Hyperplasia and the Concentration of Diphenylhydantoin in Various Tissues of Ferrets, J Dent Res51: 657-662, 1972.
14.
Steinberg, A.D.; Allen, P.; and Jeffay, H.: Distribution and Metabolism of Diphenylhydantoin in Oral and Non-Oral Tissues of Ferrets , J Dent Res52: 267-270, 1973.
15.
Butler, T.C. : The Metabolic Conversion of 5,5-Diphenylhydantoin to 5- (p-hydroxyphenyl) -5-phenylhydantoin, J Pharmacol Exp Ther119: 1-11, 1957.
16.
Maynert, E.W. : The Metabolic Fate of Diphenylhydantoin in the Dog, Rat and Man, Pharmacol Exp Ther130: 275-284, 1960.
17.
Chang, T., and Glazko, A.J.: Quantitative Assay of 5,5-Diphenylhydantoin (Dilantin*) and 5- (p-hydroxyphenyl) -5-Phenylhydantoin by Gas-Liquid Chromatography, J Lab Clin Med75: 145-155, 1970.
18.
Conard, G.J. ; Haavik, C.O.; Osborn, J.; and Hefferren, J.J.: Simultaneous Gas-Liquid Chromatographic Determination of Diphenylhydantoin and Its Metabolites in Biological Specimens , abstracted, IADR Program and Abstracts of Papers, No. 515, 1972.
