A method has been proposed that enables discrimination between genetic and intrauterine influences within the etiology of teratogen-induced craniofacial anomalies. The experimental approach is the transplantation of embryos at the blastocyst stage from mouse strains that are either highly resistant or highly susceptible to cortisone-induced cleft lip and cleft palate formation into pseudopregnant foster mothers that are reciprocally either resistant or susceptible to the congenital birth defect.
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