Of 389 patients with Down's syndrome, 18 exhibited bifid uvula (4.63%) and 3 exhibited submucous cleft palate (0.77%). The hypothesis that cleft uvula and submucous cleft palate are micromanifestations of the more severe isolated cleft palate seems to be correct.
Get full access to this article
View all access options for this article.
References
1.
Berg, J.M.; Crome, L.; and France, N.E.: Congenital Cardiac Malformations in Mongolism, Br Heart J22: 331-346, 1960.
2.
Fabia, J., and Drolette, J.: Malformations and Leukemia in Children with Down's Syndrome, Pediatrics45: 60-70, 1970.
3.
Fogh-Andersen, P.: Inheritance of Harelip and Cleft Palate, Kobenhavn: Ejnar Munksgaard, 1943 .
4.
McMillan, R.S. , and Kashgarian, M.: Relation of Human Abnormalities of Structure and Function to Abnormalities of the Dentition in Mongolism, JADA63: 368-373, 1961.
Gorlin, R.J. : Facial Clefting and Its Syndromes, Birth Defects7 (7) : 3-49, 1971.
7.
Meskin, L.H. ; Gorlin, R.J.; and Isaacson , R.J.: Abnormal Morphology of the Soft Palate. II. The Genetics of Cleft Uvula, Cleft Palate J2: 40-45, 1965.
8.
Shapiro, B.; Meskin, L.H.; Cervenka, J.; and Pruzansky, S.: Cleft Uvula: A Microform of Facial Clefts and Its Genetic Basis, Birth Defects7 (7) : 80-82, 1971.
9.
Tolarova, M. ; Havlola, Z.; and Ruzickova, J.: The Distribuiton of Characters Considered to be Microforms of Cleft Lip and/or Palate in a Population of Normal 18-21 Year Old Subjects, Acta Chir Plast (Praha ) 9: 1-14, 1969.
10.
Cervenka, J. , and Shapiro, B.L.: Cleft Uvula in Chippewa Indians: Prevalence and Genetics, Hum Biol42: 47-52, 1970.
11.
Tretsven, V.E. : Incidence of Cleft Lip and Palate in Montana Indians, J Speech Hear Disord28: 52-57, 1963.
12.
Tretsven, V.E. : Incidence of Cleft Lip and Palate in Montana , Cleft Palate Bull13: 65-66, 1963.
13.
Tretsven, V.E. : Impression Concerning Clefts in Montana Indians of the Past, Cleft Palate J2: 229-236, 1965.
14.
Altemus, L.A. : The Incidence of Cleft Lip and Palate Among NorthAmerican Negroes, Cleft Palate J3: 357-361, 1966.
15.
Altemus, L.A. , and Ferguson, A.D.: Comparative Incidence of Birth Defects in Negro and White Children, Pediatrics36: 56-61.
16.
Ivy, R.H. : The Influence of Race on the Incidence of Certain Congenital Anomalies, Notably Cleft Lip-Cleft Palate, Plast Reconstr Surg30: 581-585, 1962.
17.
Longenecker, C.G.; Ryan, R.F.; and Vin-Cent , R.W.: Cleft Lip and Cleft Palate, Incidence at a Large Charity Hospital, Plast Reconstr Surg35: 548-550, 1965.
18.
Gorlin, R.J., and Goldman, H.M.: Thoma's Oral Pathology, Sixth Edition, St. Louis : C. V. Mosby Co., 1970, pp 50-63.
19.
Schaumann, B.F. ; Peagler, F.D.; and Gorlin, R.J.: Minor Cranio-facial Anomalies Among a Negro Population. I. Prevalence of Cleft Uvula, Commissural Lip Pits, Pre-auricular Pits, Torus Palatinus, and Torus Mandibularis, Oral Surg29: 566-575, April 1970.
Stewart, J.M. ; Ott, J.E.; and Lagace, R.: Submucous Cleft Palate, Birth Defects7 (7) : 64-66, 1971.
24.
Meskin, L.H. ; Gorlin, R.J.; and Isaacson , R.J.: Abnormal Morphology of the Soft Palate: I. The Prevalence of Cleft Uvula, Cleft Palate J1: 342-347, 1964.
25.
Massengill, JR, R.: An Objective Technique for Submucous Cleft Palate Detection, Plast Reconstr Surg37: 355-359, 1966.
26.
Levinson, A. ; Friedmann, A.; and Stamps, F.: Variability of Mongolism, Pediatrics16: 43-54, 1955.
27.
Meskin, L.H. ; Gorlin, R.J.; and Isaacson , R.J.: Cleft Uvula: A Microform of Cleft Palate, Acta Chir Plast ( Praha ) 8: 91-96, 1966.
28.
Shapiro, B.L. : Prenatal Dental Anomalies in Mongolism: Comments on the Basis and Implications of Variability, Ann NY Acad Sci171:562-577, 1970.
