A large body of family data was analyzed to explain the genetics of hypodontia. Two multiple threshold models that were developed for quasicontinuous traits were used. The data fit the polygenic model much better than they fit the single major gene model.
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References
1.
Palsson, F.: Till fragan om replantation av tandanlag, Sven Tandlak Tidskr37: 192-208, 1944.
2.
Nanda, R.S.: Agenesis of the Third Molar in Man, Am J Orthod40: 698-706, 1954.
3.
Brekhus, P.J.; Oliver, C.P.; and Montelius, G.: A Study of the Pattern and Combination of Congenitally Missing Teeth in Man , J Dent Res23: 117-131. 1944.
Muller, T.P. : HILL, T.P.; PETERSEN, A.C.; and BLAYNEY, J.P .: A Survey of Congenitally Missing Permanent Teeth, JADA81: 101-107, 1970.
6.
Eidelman, E. ; Chosack, A.; and Rosenzweig , K.A.: Hypodontia: Prevalence amongst Jewish Populations of Different Origin, Am J Phys Anthropol39: 129-133, 1973.
7.
Alvesalo, L. , and Portin, P.: The Inheritance Pattern of Missing, Peg-Shaped, and Strongly Mesio-Distally Reduced Upper Lateral Incisors, Acta Odontol Scand27 : 563-575, 1969.
8.
Thomsen, S.O. : Missing Teeth with Special Reference to the Population of Tristan da Cunha, Am J Phys Anthropol10: 155-167, 1952.
9.
Huskins, C.L. : On the Inheritance of an Anomaly of Human Dentition , J Hered21: 279-282, 1930.
10.
Grahnén, H. : Hypodontia in the Permanent Dentition, Odontol Revy (supp)3: 1-100, 1956.
11.
II. Reich, T.; James, J.W.; and Morris, C.A.: The Use of Multiple Thresholds in Determining the Mode of Transmission of Semi-Continuous Traits, Ann Hum Genet36: 163-184, 1972.
12.
Falconer, D.S. : The Inheritance of Liability to Certain Diseases, Estimated from the Incidence among Relatives, Ann Hum Genet29: 51-76, 1965.
13.
Campbell, M.A. , and Elston, R.C.: Relatives of Probands: Models for Preliminary Genetic Analysis, Ann Hum Genet35: 225-236, 1971.
14.
James, J.W. : Frequency in Relatives for an All-or-None Trait , Ann Hum Genet35: 47-49, 1971.
15.
Kaplan, E.B., and Elston, R.C.: A Subroutine Package for Maximum Likelihood Estimation (MAXLIK) , Institute of Statistics Mimeo Series No. 823, Department of Bio-statistics, University of North Carolina, Chapel Hill, NC.
16.
Carter, W.J. , and Bordy, M.D.: Ectodermal Dysplasia and the Lyon Hypothesis , J Dent Child34: 256-258, 1967.
17.
Bruce, K.W. : The Effect of Irradiation on the Developing Dental System of the Syrian Hamster, Oral Surg3: 1468-1477, 1950.
18.
Garn, S.M.; Lewis, A.B.; and Vicinus, J.H.: Third Molar Agenesis and Reduction in the Number of Other Teeth, J Dent Res41: 717, 1962.
19.
Garn, S.M.; Lewis, A.B.; and Kerewsky, R.S.: Third Molar Agenesis and Size Reduction of the Remaining Teeth, Nature (Lond)200: 488-489, 1963.
20.
Garn, S.M.; Lewis, A.B.; and Bonne, B.: Third Molar Polymorphism and the Timing of Tooth Formation, Nature (Lond)192: 989, 1961.
21.
Garn, S.M., and Lewis, A.B.: The Gradient and the Pattern of Crown-Size Reduction in Simple Hypodontia , Angle Orthod40: 51-57, 1970.
22.
Butler, P.M. : Studies of the Mammalian Dentition. Differentiation of the Post-Canine Dentition, Proc Zool Soc (Lond) (B)109: 1-36, 1939.
23.
Davies, P.L. : The Significance of Agenesis of Teeth in Combinations , Austral Dent J13: 233-236, 1968.