Prostaglandin E1-containing solutions injected under the skin overlying the calvarium of adult rats produced a visible resorptive lesion within the bone in seven days. The resorptive process was characterized by fibrous replacement of bone matrix and by increased vascularity. Inflammatory cells were not apparent.
Get full access to this article
View all access options for this article.
References
1.
Brocklehurst, W.E.: Role of Kinins and Prostaglandins in Inflammation , Proc R Soc Med64: 4-6, 1971.
2.
Hinman, J.W. : Prostaglandins, Ann Rev Biochem41: 161-178, 1972.
3.
Kaley, G., and Weiner, R.: Prostaglandin E,: A Potential Mediator of the Inflammatory Response , Ann NY Acad Sci180 : 338-350, 1971.
4.
Willoughby, D.A.: The Inflammatory Response, J Dent Res51: 226-227, 1972.
5.
Bergstrom, S. ; Carlson, L.A.; and Weeks, J.R.: The Prostaglandins: A Family of Biologically Active Lipids, Pharmacol Rev20: 1-48, 1968.
6.
Horton, E.W. : Hypotheses on Physiological Roles of Prostaglandins , Physiol Rev49: 122-161, 1969.
7.
Solomon, L.M. ; Juhlin, L.; and Kirchen-Baum , M.B.: Prostaglandins on Cutaneous Vasculature, J Invest Dermatol51:280-282, 1968.
8.
Sondergaard, J., and Greaves, M.W.: Prostaglandin E1: Effect on Human Vascuiature and Skin, Br J Dermatol84: 424, 1971.
9.
Willis, A.L. : Identification of Prostaglandin E2 in Rat Inflammatory Exudate, Pharmacol Res Comm2: 297-304, 1970.
10.
Willis, A.L. : Parallel Assay of Prostaglandin-like Activity in Rat Inflammatory Exudate by Means of Cascade Superfusion, J Pharm Pharmacol21: 126-128, 1969.
11.
Anggard, E., and Johnson, C.: Formation of Prostaglandins in the Skin Following a Burn Injury in Ramwell, D.W., and Ferris, B.B. (eds) : Prostaglandins in Cellular Biology and the Inflammatory Process, New York: Plenum Press, 1972, pp 269-284.
12.
Vane, J.R.: Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs, Nature [New Biol]231:232-235, 1971.
13.
Smith, J.B. , and Willis, A.L.: Aspirin Selectively Inhibits Prostaglandin Production in Human Platelets, Nature [New Biol]231: 235-237, 1971.
14.
Ferreira, S.H. ; Moncada, S.; and Vane, J.R.: Indomethacin and Aspirin Abolish Prostaglandin Release from the Spleen, Nature [New Biol]231: 237-239, 1971.
Klein, D.C., and Raisz, L.G.: Prostaglandins: Stimulation of Bone Resorption in Tissue Culture, Endocrinology86: 1436-1440, 1970 .
17.
Voekel, E.F.; Tashjian, A.H.; and Gold-Haber, P.: A Non-peptide Produced by Fibrosarcoma Cells that Stimulates Bone Resorption in Organ Culture, in Calcium, Parathyroid Hormone and the Calcitonins , in Talmage, R.V., and Munson, P.L. (eds) : Excerpta Medica, Amsterdam, 1972.
18.
Auerbach, G.D. , and Chase, L.R.: Cyclic 3' 5' Adenylic Acid in Bone and the Mechanism of Action of Parathyroid Hormone, Fed Proc29: 1179-1182, 1970.
19.
Ferreira, S.H. , and Vane, J.R.: Prostaglandins : Their Disappearance from and Release into the Circulation, Nature ( Lond) 216: 868, 1970.
20.
Samuelsson, B.; Granstrom, E.; Green , K.; and Hamberg, M.: Metabolism of Prostaglandins. Ann NY Acad Sci180: 138-161, 1971.
21.
Glickman, I. , and Wood, H.: Bone Histology in Periodontal Disease, J Dent Res21: 35-54, 1942.
22.
Mergenhagen, S.E.; Tempel, T.R.; and Snyderman , R.: Immunologic Reactions and Periodontal Inflammation, J Dent Res49: 256-267, 1970.
23.
Movat, H.Z. ; Macmorine, D.R.L.; and Takeuchi , T.: The Role of PMN-Leucocyte Lysosomes in Tissue Injury, Inflammation and Hypersensitivity , Int Arch Allergy Appl Immunol40:218-235, 1971.
24.
Horton, J.E. ; Raisz, L.G.; Simmons , A.A.; Oppenheim, J.J. ; and Mergenhagen , S.E.: Bone Resorbing Activity in Supernatant Fluid from Cultured Human Peripheral Blood Leucocytes, Science177: 793-795, 1972.
