Rats that had their mandibular first molars silk-ligated and that were fed chow with diphenylhydantoin sodium (Dilantin) developed less caries than rats that were not fed Dilantin. The retarding effect of Dilantin was enhanced by the cleanliness of the environment in which the animals lived.
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References
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Rovin, S.; Shteyer, A.; Howell, R.M.; and Gordon, H.A.: Caries Due to Food Retention in Nonsusceptible Rats Fed a Noncariogenic Diet , J Dent Res50: 105-108, 1971.
