The rate of bile secretion in fasted male rats and corresponding bile and plasma fluoride concentrations were studied to determine if significant quantities of fluoride are secreted into the small intestine from the bile duct during fluoride absorption. The osmolalities and fluoride levels were similar to those of plasma ; this suggests that the rat biliary system does not concentrate fluoride.
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References
1.
Machle, W., and Largent, E.J.: The Absorption and Excretion of Fluorides. Part II. The Metabolism of High Levels of Intake, J Ind Hyg Toxicol25: 112-123, 1943.
2.
Collings, G.H. , JR.; Fleming, R.B.L.; and May , R.: Absorption and Excretion of Inhaled Fluorides, Arch Indust Hyg4 : 585-590, 1951.
3.
Hein, J.M.; Bonner, J.F.; Brudevold, F.; Smith, F.A.; and Hodge, H.C.: Distribution in the Soft Tissue of Rat of Radioactive Fluoride Administered as Sodium Fluoride, Nature (Lond) 178: 1295-1296, 1956.
4.
Bell, M.C.; Merriman, G.M.; and Green-Wood, D.A. : Distribution and Excretion of F18 Fluoride in Beef Cattle, J Nutr73: 379-385, 1961.
5.
Wallace-Durbin, P.: The Metabolism of Fluoride in the Rat Using F18 as a Tracer, J Dent Res33: 789-800, 1954.
6.
Parkins, F.M. ; Hollifield, J.W.; Mccasline, A.J.; Wu, S-M.L. ; and Faust, R.G.: Active Transport of Fluoride by the Rat Intestine In Vitro, Biochim Biophys Acta126 : 513-524, 1966.
7.
Parkins, F.M. : Active F- Transport: Species and Age Effects with Rodent Intestine In Vitro, Biochim Biophys Acta241:507-512, 1971.
8.
Zipkin, I., and Likins, R.C.: Absorption of Various Compounds from the Gastrointestinal Tract of the Rat , Am J Physiol191: 549-550, 1957.
9.
Parkins, F.M. , and Faust, R.G.: Possible Intestinal Regulation of Fluoride Blood Levels, abstracted, IADR Program and Abstracts of Papers , No. 46, 1966.
10.
Parkins, F.M. , and Greenlimb, P.E.: Fluoride Absorption from Segments of Rat Intestine In Vivo, abstracted, IADR Program and Abstracts of Papers, No. 149, 1972.
11.
Friedman, M. ; Byers, S.O.; and Michaelis , F.: Observations Concerning Production and Excretion of Cholesterol in Mammals. II. Excretion of Bile in the Rat, Am J Physiol162: 575-578, 1950.
12.
McCann, H.G.: Determination of Fluoride in Mineralized Tissues Using the Fluoride Ion Electrode, Arch Oral Biol13:475-477, 1968.
13.
Wharton, H.W. : Isolation and Determination of Microgram Amounts of Fluoride in Materials Containing Calcium and Orthophosphate, Anal Chem34: 1296-1298, 1962.
14.
Snedecor, G.W. , and Cochran, W.G.: Statistical Methods, 6th ed, Ames, Iowa: The Iowa State University Press, 1967, pp 59-62.
15.
PARKINS, F.M., and GREENLIMB, P.E.: Blood F- Analysis, unpublished manuscript.
16.
Schmidt, C.R. , and Ivy, A.C.: The General Function of the Gall Bladder , J Cell Physiol10: 365-383, 1937.
