131I-4-iodoantipyrine clearances from injection sites in oral submucosa were at least twice as rapid as clearances in subcutaneous tissue in cats. There was a positive correlation between the rapidity of clearances in the two tissues. Epinephrine, a vasoconstrictor, depressed clearances in both tissues, whereas papaverine, a vasodilator, increased clearances.
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References
1.
Glickman, I.: Clinical Periodontology, Philadelphia : W. B. Saunders Co., 1964, p 902.
2.
Forsslund, G. : Stereomicroscopy of Oral and Gingival Capillaries , Acta Odontol Scand (suppl 17): 121, 1959.
3.
Brill, N., and Krasse, B.: The Passage of Tissue Fluid into the Clinically Healthy Gingival Pocket, Acta Odontol Scand16: 233-245, 1958.
4.
Majno, G., and Palade, G.E.: Studies on Inflammation. I. The Effect of Histamine and Serotonin on Vascular Permeability: An Electron Microscopic Study, J Biophys Biochem Cytol11: 571-605, 1961.
5.
Weinstein, E. ; Pappas, G.D.; Mandel, I.D.; Salkind, A.; and Oshrain, H.: Studies of Gingival Fluid, abstracted, IADR Program and Abstracts of Papers, No. 143, 1965.
6.
Dorman, H.C. , and Bishop, J.G.: Changes in Vascular Resistance Following Induction of Chronic Unilateral Periodontitis in Dogs, J Dent Res41: 453-458, 1962.
7.
Kety, S.S.: Measurement of Regional Circulation by Local Clearance of Radioactive Sodium , Am Heart J38: 321-328, 1949.
Hyman, C.: Tissue Clearance: What It Does Measure, J Invest Dermatol48: 95, 1967.
10.
Gangarosa, L.P.: Comparison of Subcutaneous and Oral Submucosal Clearance of Injected P32, abstracted, IADR Program and Abstracts of Papers, No. 106, 1967.
11.
Lindbjerg, I.F.: Disappearance Rate of 133Xenon, 4-Iodoantipyrine 133I and 131I- from Human Skeletal Muscles and Adipose Tissue, Scand J Clin Lab Invest19: 120-128, 1967.
12.
Brigham, K.L. ; Ramsey, L.H.; Snell, J.D.; and Merritt, C.R.: On Defining the Pulmonary Extravascular Water Volume, Circ Res29: 385-397, 1971.
13.
Gangarosa, L.P., and Cheong, D.K.: Local Anesthetic Inhibition of Subcutaneous Absorption in Rats, Proc Soc Exp Biol Med133: 1169-1171, 1971.
14.
Snedecor, G.W. , and Cochran, W.G.: Statistical Methods, 6th ed, Ames, Iowa: The Iowa State University Press, 1967, p 259.
15.
Gangarosa, L.P.: Tissue Isotope Clearance. II. Reduction of Clearance by Pentobarbital Infusion, Proc Soc Exp Biol Med137: 1372-1374, 1971.
16.
Friedman, E.; Kopald, H.H.; and Smith, T.R.: Retinal and Choroidal Blood Flow Detremined with Krypton-85 Anesthetized Animals , Invest Ophthalmol3: 539-547, 1964.
17.
Solomon, A.K.: Mineral Metabolism, Vol 1, New York: Academic Press, 1960, p 138.
18.
Lassen, N.A.; Lindbjerg, J.; and Munck, O.: Measurement of Blood-Flow Through Skeletal Muscle by Intramuscular Injection of Xenon-133, Lancet1:686-689, 1964.
19.
Munck, O.; and Andersen, A.M.: Decomposition of Iodine Labelled Antipyrine, Scand J Clin Lab Invest19: 256-258, 1967.
20.
Forsslund, G. : Disappearance Rate of Sodium ions from Submucosly Injected Deposits in the Oral Vestibule of the Rabbit, Acta Odontol Scand19: 239-246, 1961.
21.
Franke, F.R. ; Boatman, J.B.; George, R.S.; and Moses, C.: Effect of Physical Factors on Radiosodium Clearance from Subcutaneous and Intramuscular Sites in Animals, Proc Soc Exp Biol Med74: 417-421, 1950.
22.
Walder, D.N.: Blood Flow Through Organs and Tissues, Baltimore: Williams and Wilkins Co., 1968, p 383.
23.
Edwall, L., and Kindlova, M.: The Effect of Sympathetic Nerve Stimulation on the Rate of Disappearance of Tracers from Various Oral Tissues, Acta Odontol Scand29: 387-400, 1971.