Estradiol benzoate in daily doses of 3, 10, or 30 μg was administered for one month to castrated or to castrated-adrenalectomized mice. Histologic and histometric studies of the submaxillary glands were performed. There was submaxillary hypertrophy caused by the granular tubules in the estradiol-injected mice. Adrenalectomy did not interfere with this effect.
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