The effect of phosphate concentration and the initial pH of bacteriologic media on acid production and bacterial growth of Streptococcus mutans was studied. There was an inhibition of acid production and bacterial growth with an increase in concentrations of phosphate, particularly when the initial pH of the media was 8.0. At a pH of 6.5 the effect was minimal.
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References
1.
Ostrom, C.A. , and Vanreen, R.: Systemic Phosphate Influences on Dental Caries in NMRI D-Rat, J Dent Res42: 732-738, 1963.
2.
Gilmore, N.D. : The Effect on Dental Caries-Activity of Supplementing Diets with Phosphates : A Review, J Public Health Dent29: 188-207, 1969.
3.
Ericsson, Y. : Some Differences Between Human and Rodent Saliva of Probable Importance for the Different Species Reactions to Cariogenic and Cariostatic Agents, Adv Fluorine Res, 327-336, 1962.
4.
Charlton, G. ; Fitzgerald, R.J.; and Keyes, P.H.: Determination of Saliva and Dental Plaque pH in Hamsters with Glass MicroElectrodes, Arch Oral Biol16: 649-654, 1971. 5. Gibbons, R.J., and Banghart, S.: Induction of Dental Caries in Gnotobiotic Rats with Levan-Forming Streptococcus and a Streptococcus Isolated from Subacute Bacterial Endocarditis, Arch Oral Biol13:297-308, 1968.
5.
Wilson, T.E. , and Evans, D.J. JR.: The Oral Yeast-Lactobacillus Relationship. IV. pH and Phosphate Concentration as Contributing Factors, J Dent Res45: 297-302, 1966.
6.
Fitting, C., and Scherp, H.W.: Observations on a Strain of Neisseria meningitidis in the Presence of Glucose and Maltose, J Bacteriol61: 203-214, 1951.
7.
Dalderup, L.M. , and Backer-Dirks , 0.: The Effects of Phosphates on the Metabolism of Glucose and on the Cariogenicity of Commercial Sweets in Rats, J Dent Res45: 410, 1966.
8.
Bramstedt, F. , and Lusty, C.J.: The Nature of the Intracellular Polysaccharides Synthesized by Streptococci in the Dental Plaque, Caries Res2: 201-213, 1968.
9.
Cerbon, J., and Ortigoza-Ferado, J.: Phosphate Dependence of Monosaccharide Transport in Nocardia, J Bacteriol95: 350-354, 1968.
10.
Elliott, R.P. ; Straka, R.P.; and Garibaldi , J.A.: Polyphosphate Inhibition of Growth of Pseudomonads from Poultry Meat, Appl Microbiol12:517-522, 1964.
11.
Post, F.J.; Krishramurty, G.B.; and Flan-Agan, M.D.: Influence of Sodium Hexametaphosphate on Selected Bacteria, Appl Microbiol11:430-435, 1963.
12.
Henry, C.A.: Study of the Early Development of Rat Caries and Concurrent Microbial Changes as Influenced by Trimetaphosphate, PhD thesis, Massachusetts Institute of Technology, Cambridge, Massachusetts , 1968.
13.
Handelman, S.L.; Mills, J.R. ; and Megco, L.: A Medium of Differentiating Acidogenic Bacteria , Arch Oral Biol13: 1187-1196, 1968 .
14.
Adler, E.; Von Euler, Guenther, G.; and Plass, M.: Isocitric Dehydrogenase and Glutamic Acid Synthesis in Animal Tissues , Biochern J33: 1028-1045, 1939 .
15.
Kearny, E.B. , and Singer, T.P.: The Inactivation of L-Amino Acid Oxidase by Inorganic Phosphate and Arsenate , Arch Biochem21:242-245, 1949.
16.
Wittenberger, C.L., and Angelo, N.: Purification and Properties of a Fructose-1, 6-Diphosphate-Activated Lactate Dehydrogenase from Streptococcus faecalis , J Bacteriol101:717-724, 1970.
17.
Englander, H.R., and Keyes, P.H.: Effect of Phosphate Supplements on Cavitation in Hamsters Infected with Caries-Conducive Streptococci, J Dent Res49: 140-144, 1970.
18.
Henry, C., and Navia, J.: Sodium Trimetaphosphate Influence on the Early Development of Rat Caries and Concurrent Microbial Changes, Caries Res3: 326-338, 1969.
