Cleft palates were induced experimentally in rat fetuses by means of the teratogenic action of Lathyrus odoratus and vitamin A. The results showed that this malformation is associated with other facial anomalies; the nasal septum cartilage was reduced in height and the mandible became thicker.
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References
1.
Aduss, H. , and Pruzansky, S.: Postnatal Craniofacial Development in Children With the Oral-Facial-Digital Syndrome, Arch Oral Biol9:193-203, 1964.
2.
Bixler, D.; Spivack, J.; and Christian, J.C.: A New Syndrome of Facial and Hand Malformations, abstracted, IADR Program and Abstracts of Papers, No. 310, 1970.
3.
Calnan, J.: Palato-Pharyngeal Incompetence in Speech, in Pruzansky, S. (ed): Congenital Anomalies of the Face and Associated Structures, Springfield, III: Charles C Thomas, 1961, pp 104-122.
4.
Pannbacker, M.: Congenital Malformations and Cleft Lip and Palate, Cleft Palate J5:334-339, 1968.
5.
Pruzansky, S. : Postnatal Development of Craniofacial Malformations , J Dent Res47:936, 1968.
6.
Pruzansky, S. ; Peterson, S.; Valvassori , G.E.: Interrelations of Findings in a Syndrome With Congenital Malformations of the External Ear, Temporal Bone, Face, and Mandible, abstracted, IADR Program and Abstracts of Papers, No. 339, 1968.
7.
Abramovich, A., and Devoto, F.C.H.: Condrogenesis maxilofacial ectópica en fetos de ratas tratadas con altas dosis de vitamina A, Rev Asoc Odontol Argent55: 237-242, 1967.
8.
Abramovich, A., and Devoto, F.C.H.: Comparacion entre fisuras palatinas producidas por hipervitaminosis A y latirismo, Rev Soc Argent Biol43:94-101, 1967.
9.
Abramovich, A., and Devoto, F.C.H.: Lesiones congenitas maxilofaciales obtenidas con diferentes dosis de vitamina A, Rev Soc Argent Biol43:121-128, 1967.
10.
Abramovich, A., and Devoto, F.C.H.: Anomalous Maxillofacial Patterns Produced By Maternal Lathyrism in Rat Foetuses, Arch Oral Biol13:823-826, 1968.
11.
Abramovich, A.: Cleft Palate in the Fetuses of Lathyric Rats and Its Relation to Other Structures: Nasal Septum, Tongue and Mandible, Cleft Palate J9:73-83, 1972.
12.
Scott, J.H.: The Cartilage of the Nasal Septum, Br Dent J95:37-43, 1953.
13.
Baume, J.L.: Patterns of Cephalofacial Growth and Development, A Comparative Study of the Basicranial Growth Centers in Rat and Man, Int Dent J18:489-513, 1968.
14.
McLaughlin, C.R. : Absence of the Septal Cartilage With Retarded Nasal Development, Br J Plast Surg2:61-64, 1950.
15.
Moss, M.L.; Bromberg, B.E.; Song, I.C.; and Eisenman, G.: The Passive Role of Nasal Septum Cartilage, Plast Reconstr Surg41:536-542, 1968.
16.
Stenstrom, S.J. , and Thilander, B.L.: Effects of Nasal Septal Cartilage Resections on Young Guinea Pig, Plast Reconstr Surg45:160-170, 1970.
17.
Sarnat, B.G. , and Wexler, M.R.: Growth of the Face and Jaw After Resection of the Septal Cartilage in the Rabbit, Am J Anat118:755-768, 1966.
18.
Avery, J.K. ; Happle, J.D.; and French, W.C.: Development of the Nasal Capsule in Normal and Cleft Palate Formation, Cleft Palate Bull7:8, 1957.
19.
Avery, J.K. , and Devine, R.: Development of Ossification Centers in the Face and Palate of Normal and Cleft Palate Human Embryos, Cleft Palate Bull9 :25-26, 1959.
20.
Hart, J.C., and Smiley, G.R.: Growth of the Craniofacial Complex in Normal and Bilateral Spontaneous Cleft A/Jax Mice, abstracted, IADR Program and Abstracts of Papers, No. 153, 1969.
21.
Vanek, R.J.; Smiley, G.R.; and Dixon, A.D.: Coronal Growth of the Craniofacial Complex During Secondary Palatal Formation , abstracted, IADR Program and Abstracts of Papers, No. 440, 1970.
22.
Gardner, A.F. ; Dasler, W.; and Wein-Mann, J.: Masticatory Apparatus of Albino Rats in Experimental Lathyrism, J Dent Res37:492-515, 1958.
