Tissue distribution of diphenylhydantoin and metabolites in oral and nonoral tissues of the ferret after administration of single and multiple doses revealed that prolonged administration resulted in high concentrations of unmetabolized DPH in oral mucosa, salivary glands, and gingiva. This suggests a direct role of unmetabolized DPH in the induced gingival hyperplasia.
Get full access to this article
View all access options for this article.
References
1.
King, J.D.: Experimental and Clinical Observations in Gingival Hyperplasia Due to Epanutin , Br Dent J96:237-248, 1954.
2.
Abadom, P.N.: The Pharmacological Reactions and Metabolism of 5-5 Diphenylhydantoin in the Ferret, MS thesis, University of Rochester, New York, 1959.
3.
Steinberg, A. ; Alvarez, J.; and Jeffay, H.: Lack of Relationship Between the Degree of Dilantin Induced Gingival Hyperplasia, Turnover of H3 Proline and the concentration of Dilantin in Various Tissues of Ferrets, J Dent Res51:657-662, 1972.
4.
Dill, W.; Kazenko, A.; Wolf, L.; and Glazko, A.: Studies on 5-5 Diphenylhydantoin in Animals and Man, J Pharmacol Exp Ther118:270-279, 1956.
5.
Noach, E.L.; Woodbury, D.M.; and Goodman, L.S.: Studies on the Absorption, Fate, and Excretion of 4-C14 Labeled Dilantin , J Pharmacol Exp Ther122:301-314, 1958.
6.
Nakamura, K. ; Masuda, Y.; and Nakat-Sujusi , K.: Tissue Distribution and Metabolic Fate of 3-Ethoxycarbonyl 5,5-Diphenylhydantoin (p-6127) and 5,5-Diphenylhydantoin in Rats, Arch Int Pharmacodyn Ther165:103-111, 1967.
7.
Staple, P.H. , and Emslie, R.D.: Some Tissue Reactions Associated with Dilantin Sodium, Int Dent J3:190-196, 1952.
