Rabbit aortic strips were used to investigate and compare the interactions of epinephrine and norepinephrine with cocaine, procaine, and lidocaine. Cocaine potentiated responses to epinephrine and norepinephrine. Responses to epinephrine were antagonized by procaine and lidocaine and responses to norepinephrine were potentiated. Lidocaine possessed some intrinsic activity.
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References
1.
Fröhlich, A. , and Loewi, O.:Über eine Steigerung der Adrenalinempfindlichtkeit durch Cocain, Arch Exp Path Pharmakol62:159-169, 1910.
2.
Maxwell, R.A. ; Daniel, A.I.; Sheppard , H.; and Zimmerman, J.H.: Some Interactions of Guanethidine, Cocaine, Methylphenidate and Phenylalkylamines in Rabbit Aortic Strips, J Pharmacol Exp Ther137: 31-38, 1962.
3.
Furchgott, R.F.; Kirpekar, S.M.; Rieber, M.; and Schwab M.: Actions and Interactions of Norepinephrine, Tyramine and Cocaine on Aortic Strips of Rabbit and Left Atria of Guinea Pig and Cat, J Pharmacol Exp Ther142:39-58, 1963.
4.
Maxwell, R.A.; Wastila, W.B.; and Eckhardt, S.B.: Some Factors Determining the Response of Rabbit Aortic Strips to dl-Norepinephrine-7-H3 Hydrochloride and the Influence of Cocaine, Guanethidine and Methylphenidate on These Factors, J Pharmacol Exp Ther151:253-261, 1966.
5.
Nava-Rivera, J.; Gutierrez-Lopez, A.; and Eisenberg, J.W.: Influence of Procaine, Lidocaine and Prilocaine on the Adrenaline Contraction of Isolated Strips of Rabbit Aorta, Arch Int Pharmacodyn Ther169: 308-311, 1967.
6.
Kalsner, S., and Nickerson, M.: Mechanism of Cocaine Potentiation of Responses to Amines, Br J Pharmacol35:428-439, 1969.
7.
Astrom, A.: Influence of Some Local Anesthetics Upon the Adrenaline Contraction of Isolated Strips of Rabbit Aorta, Acta Physiol Scand60:30-38, 1964.
8.
Moller, K.O. : The Effect of Cocaine and Procaine on the Action of Adrenaline on Skin Vessels. Vascular Action of Cocaine and Procaine in the Perfused Rabbit Ear, Arch Int Pharmacodyn Ther57:51-63, 1937.
Giering, J.E. , and Truant, A.P.: Lidocaine Sensitization of the In Vitro Rat Uterus to Action of Epinephrine, Fed Proc16:300, 1967.
11.
Macmillan, W.H.: A Hypothesis Concerning the Effect of Cocaine on the Action of Sympathomimetic Amines, Br J Pharmacol14 :385-391, 1959.
12.
Innes, I.R. : An Action of 5-Hydroxytryptamine on Adrenaline Receptors, Br J Pharmacol19:427-441, 1962.
13.
Fleckenstein, A.: A Quantitative Study of Antagonists of Adrenaline on the Vessels of the Rabbit's Ear, Br J Pharmacol7: 553-562, 1952.
14.
Furchgott, R.F., and Bhadrakom , S.: Reactions of Strips of Rabbit Aorta to Epinephrine, Isopropylarterenol, Sodium Nitrite and Other Drugs, J Pharmacol Exp Ther108:129-143, 1953.
15.
Bevan, J.A. : The Use of the Rabbit Aorta Strip in the Analysis of the Mode of Action of 1-Epinephrine on Vascular Smooth Muscle, J Pharmacol Exp Ther129 :417-427, 1960.
16.
Snedecor, G.W. : Statistical Methods, 5th ed, Ames, Iowa: The Iowa State College Press, 1956.
17.
Ahlquist, R.P. : A Study of the Adrenotropic Receptors, Am J Physiol153 :586-600, 1948.
18.
Ahlquist, R.P. ; Taylor, J.P.; Rawson , C.W.; and Sydon, V.L.: Comparative Effects of Epinephrine and Levarterenol in the Intact Anesthetized Dog, J Pharmacol Exp Ther110:352-360, 1954.
19.
Wilkie, D.: The Relation Between Concentration and Action of Adrenaline, J Pharmacol Exp Ther34:1-14, 1928.
20.
Cantoni, G.L. , and Eastman, G.: On the Response of the Intestine to Smooth Muscle Stimulants, J Pharmacol Exp Ther87 :392-399, 1946.
