Rats subjected to 600 R total body radiation were studied. Changes in the epiphyseal cartilage were examined from the morphologic and enzymatic aspects, and were correlated with changes in the marrow contents and underlying bone. Changes noted were specific for radiation damage and were not caused by nutritional deficiencies.
Get full access to this article
View all access options for this article.
References
1.
Blackburn, J. , and Wells, A.B.: Radiation Damage to Growing Bone: The Effect of X-Ray Doses of 100 to 1000 R on Mouse Tibia and Knee Joint, Brit J Radio36 :505-513, 1963.
2.
Dahl, B.: Effets des rayons X sur les os longs en developpement, J Radiol Electrol Med Nucl18:131-140, 1934.
3.
Gall, E.A.; Lingley, J.R.; and Hilcken, J.A.: Comparative Experimental Studies of 200 Kilovolt and 1000 Kilovolt Roentgen Rays. I. The Biological Effects on the Epiphysis of the Albino Rat, Amer J Path16:605-618, 1940.
4.
Heller, M.: Histopathology of Irradiation from External and Internal Sources, W. Bloom (ed), Nat Nuc Energy Series, Div. IV, New York: McGraw, 1948.
5.
Bavetta, L.; Bernick, S.; and Ershoff, B.: Effect of Caloric Restriction on the Bones and Periodontium in Rats, Arch Path68: 630-636, 1959.
6.
Wilkins, W.E. , and Regen, E.M.: The Influence of Roentgen Rays on the Growth and Phosphatase Activity of Bone, Radiology22:674-677, 1934.
7.
Cohn, S.H., and Gong, J.K.: Effect of 500 Roentgen Whole Body X-Irradiation on the Growth and Metabolism of Rat Bone, US Navy Def Lab3:21-28, 1963.
8.
Von Putzke, H.P.: Histochemische Untersuchungen der Tibia Epiphyse der Ratte nace Roentgen und Kobaltbestrahlung, Acta Histochem15:241-250, 1963.
9.
Vaes, G.: Hydrolytic Enzymes and Lysosomes in Bone Cells, in Richelle, L.J., and Dallemagne, M.J. (eds): Calcified Tissues, Liege: L'Universite de Liege, 1965, p 51.