Effect of a Dorsal Dermal Surgical Wound on the Chemical Response of Rat Abdominal Skin to Chronic Administration of Sodium Diphenylhydantoin

Abstract

A dorsal dermal surgical wound inflicted five days before excision of abdominal skin from young rats that were under treatment with daily injections of sodium diphenylhydantoin (100 or 50 mg/ kg) greatly modified the dermal chemical response to this drug that was observed in unwounded animals. Sodium diphenylhydantoin failed to increase wound rupture strength.

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