Actinobolin, an antibiotic that is inhibitory in vitro for cariogenic streptococci and that has strong cariostatic activity in vivo, appears to exert a bacteriostatic effect on Streptococcus faecalis. In S faecalis, the primary action of actinobolin seems to be in protein synthesis.
Get full access to this article
View all access options for this article.
References
1.
Haskell, T.H.; Ehrlich, J.; Pittillo, R.F.; and Anderson, L.E.: US Patent 3,043,830, 1962.
2.
Hunt, D.E.; Sandham, H.J.; and Cald-Well, R.C.: In Vitro Sensitivity of Oral Microorganisms to Actinobolin, J Dent Res49:137-139, 1970.
3.
Hunt, D.E.; Navia, J.M.; and Lopez, H.: In Vivo Cariostatic Activity of Actinobolin, J Dent Res50:371-373, 1971.
4.
Pittillo, R.F.; Fisher, M.W.; McAlpine, R.J.; Thompson, P.E.; and Ehrlich, J.: Actinobolin, a New Broad-Spectrum Antibiotic. Origin and Biologic Evaluation , in Welch, H., and Marti-Ibañez, F. (eds): Antibiotics Annual 1958-1959, New York: Medical Encyclopedia Inc., 1959, pp 497-504.
5.
Munk, M.E.; Nelson, D.B.; Antosz, F.J.; Herald, D.L., JR.; and Haskell, T.H.: The Structure of Actinobolin, J Amer Chem Soc90:1087-1089, 1968.
6.
Pittillo, R.F. ; Schabel, F.M., JR. ; and Quinnelly , B.G.: Studies on the Antimicrobial Nature of Action of Actinobolin, Antibiot Chemother11:501-511, 1961.
7.
Hunt, D.E.; Pittillo, R.F.; Johnson, E.P.; and Moncrief, F.C.: The Effect of Actinobolin on Nucleic Acid and Protein Synthesis in Escherichia coli, Canad J Microbiol12:515-520, 1966.
8.
Hunt, D.E., and Pittillo, R.F.: Actinobolin-Induced Filamentation in Escherichia coli, J Bact95:712, 1968.
9.
Smithers, D. ; Bennett, L.L.; and Struck, R.F.: Inhibition of Protein Synthesis in Mammalian Cells by Actinobolin, Molec Pharmacol5:433-445, 1969.
10.
Haskell, T.H. , and Bartz, Q.R.: Actinobolin, a New Broad-Spectrum Antibiotic. Isolation and Characterization, in Welch, H., and F. Marti-Ibañez, F. (eds): Antibiotics Annual 1958-1959, New York: Medical Encyclopedia Inc., 1959, pp 505-509.
11.
Chang, F.N., and Weisblum, B.: Lincomycin, in GoTtlieb, D., and Shaw, P.D. (eds) : Antibiotics I. Mechanism of action, New York: Springer-Verlag New York Inc., 1967, pp 440-445.
12.
Sandham, H.J. : Personal communication.
13.
Lowry, O.H. ; Rosebrough, N.J.; Farr , A.L.; and Randall, R.J.: Protein Measurement with the Folin Phenol Reagent, J Biol Chem193:265-275, 1951.
14.
Ogur, M., and Rosen, G.: The Nucleic Acids of Plant Tissues: I. The Extraction and Estimation of Desoxypentose Nucleic Acid and Pentose Nucleic Acid, Arch Biochem25:262-276, 1950.
15.
Mejbaum, W.: Uber die Bestimmung kleiner Pentosemengen, insbesondere in Derivaten den Adenylsaure , Z Physiol Chem258:117-120, 1939.
16.
Burton, K.: A Study of the Conditions and Mechanisms of the Diphenylamine Reaction for the Colorimetric Estimation of Deoxyribonucleic Acid, Biochem J62 :315-323, 1956.
17.
Park, J.T., and Hancock, R.: A Fractionation Procedure for Studies of the Synthesis of Cell-wall Mucopeptide and of Other Polymers in Cells of Staphylococcus aureus, J Gen Microbiol22:249-258, 1960.
18.
Hunt, D.E., and Pittillo, R.F.: Antifungal Action of 1,3-bis(2-chloroethyl)-1-nitrosourea, in Hobby, G.L. (ed): Antimicrobial Agents and Chemotherapy - 1965, Ann Arbor: American Society for Microbiology, 1966, pp 710-716.
19.
Gale, E.F.: The Synthesis of Protein and Nucleic Acids, in Gunsalus, I.C., and Stanier, R.Y. (eds): The Bacteria, Vol 3: Biosynthesis, New York : Academic Press, 1962, pp 471-576.