The tranquilizer chlorpromazine has been shown to be a potent local anesthetic. In this study chlorpromazine was injected into the mandibular gingiva of dogs to study possible irritating effects on the oral tissue. Results showed no evidence of irritation. Chlorpromazine may be useful as a local anesthetic in dentistry.
Get full access to this article
View all access options for this article.
References
1.
Welborn, J.F. , and Kane, J.P.: Conduction Anesthesia Using Diphenhydramine Hydrochloride, JAMA69:706-709, 1964.
2.
Rosenthal, S.R. , and Minard, D.: Experiments on Histamine as the Chemical Mediator for Cutaneous Pain, J Exp Med70:415-425, 1939.
3.
Halpern, B.N. ; Perrin, G.; and Dews, P.B.Pouvoir Anesthesique Local de Quelques Antihistaminiques de Synthese. Relation Entre l'Action Anesthesique et l'Action Antihistaminique , C R Soc Biol ( Paris) 114:1125-28, 1947.
4.
Friedlander, S., and Feinberg, S.M.: Histamine Antagonists. III. The Effect of Oral and Local Use of a β-Dimethylaminoethyl Benzhydryl Ether Hydrochloride on the Whealing Due to Histamine, Antigen-Antibody Reactions, and Other Whealing Mechanism: Therapeutic Results in Allergic Manifestations, J Allergy17: 129-141, 1946.
5.
Meyer, R.A., and Jakubowski, W.: The Anesthetic Properties of Antihistamines, Amer J Hosp Pharm20:136-139, 1963.
6.
Meyer, R.A., and Jakubowski, W.: Use of Tripelennamine and Diphenhydramine as Local Anesthetics, JAMA69:112-117, 1964.
7.
Smith, J.R.: Diphenhydramine Hydrochloride Used as a Local Anesthetic for Tooth Removal: Report of a Case, J Oral Surg19:418-419, 1961.
8.
Naranjo, P., and Naranjo, E.B.: Los Antihistaminicos como Anesthesicos Locales, Bol Inform Cient Nac9:33-41, 1957.
9.
Halpern, B.N. ; Perrin, G.; and Dews , P.B.: Pouvoir Anesthesique Local de Quelques Antihistaminiques de Synthese. Relation Entre l'Action Anesthesique et l'Action Antihistaminique, J Physiol ( Paris) 40:210-A-214-A, 1948.
10.
Binet, L., and Bürstein, M.: Effect Antihistaminique Local du N-dimethyl-amino-2-propyl-l-thiodiphenylamine (3277 R. P.) Injecte Par Voie Intraatrerielle, C R Soc Biol (Paris) 144:373-376, 1950.
11.
Kopera, J., and Armitage, A.K.Comparison of Some Pharmacological Properties of Chlorpromazine, Promethazine and Pethidine, Brit J Pharmacol9 :393-401, 1954.
12.
Courvoisier, S.; Fournel, J.; Ducrot , R., Kolsky, M.; and Doetschet, P.: The Pharmacy of 3-chloro-10-(3-dimethylaminopropyl)-phenothiazine-HCI, a Substance which Potentiates Anesthetics and Causes Hibernation, Arch Int Pharmacodyn92: 305-361, 1953.
13.
Goodman, L.S., and Gilman, A.The Pharmacological Basis of Therapeutics, 3rd ed, New York: The MacMillan Co. , 1965, p 169.
14.
Adriani, J.: Symposium: Adverse Drug Reactions. Reactions to Local Anesthetics , JAMA196:405-408, 1966.
15.
Meyler, L.: Side Effects of Drugs, 4th ed, New York: Excerpta Medica Foundation, 1964, p 66.
16.
Goodman, L.S., and Gilman, A.: The Pharmacological Basis of Therapeutics, 3rd ed, New York: The MacMillan Co. , 1965, p 168.
17.
Dobkin, A.B. ; Gilbert, R.G.B.; and Lamoureux , L.: Physiological Effects of Chlorpromazine, Anesthesia ( London ) 9: 157-174, 1954.
