Respiratory inhibition by amobarbital, and by the combined action of amobarbital and cyanide, was measured in bovine dental pulp slices. The oxygen consumption rate was depressed by approximately 85% under both conditions, and it is believed that this represents almost the entire portion devoted to respiratory processes. Since a prior study showed that approximately 59% of pulpal oxygen consumption was used in cyanide-sensitive respiration, it is concluded that approximately 26% is consumed in cyanide-stable respiration. A significant portion of the remaining 15% may be involved in the hydroxylation of proline necessary for collagen synthesis in dentinogenesis.
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