The addition of 18.8 or 37.6 ppm of the antibiotic actinobolin to the diets of rats reduced significantly the total incidence of caries by 56 and 81 %, respectively. The reduction in caries obtained with actinobolin, compared with non treated control rats and rats treated with 25 ppm of fluoride, indicates the potential use of this antibiotic as a cariostatic agent.
Get full access to this article
View all access options for this article.
References
1.
Haskell, T.H.; Ehrlich, J.; Pittillo, R.F.; and Anderson, L.E.: US Patent 3,043,830, 1962.
2.
Suguira, K., and Reilly, H.C.: The Effects of Actinobolin on a Spectrum of Tumors, in Welch, H., and Marti-Ibanez, F. (eds): Antibiotics Annual 1958-59, New York: Medical Encyclopedia, Inc., 1959, pp 522-527.
3.
Schabel, F.M., JR.; Laster, W.R., JR.; and Trader, M.W.: Proc Amer Assn Cancer Res 9:62, 1968.
4.
Hunt, D.E.; Sandham, H.J.; and Cald-Well, R.C.: In Vitro Antibiotic Sensitivity of Oral Microorganisms to Actinobolin , J Dent Res49:137-139, 1970.
5.
Fitzgerald, R.J.; Keyes, P.H.; Stroudt , T.H.; and Spinell, D.M.: The Effects of a Dextranase Preparation on Plaque and Caries in Hamsters: A Preliminary Report, JADA76:301-304, 1968.
6.
Navia, J.M.; Lopez, H.; and Harris, R.S.: Purified Diet for Dental Caries Research with Rats, J Nutr97:133-149, 1969.
7.
Keyes, P.H.: Dental Caries in the Molar Teeth of Rats, J Dent Res37:1088-1099, 1958.
8.
Haskell, T.H. , and Bartz, Q.R.: Actinobolin, a New Broad-Spectrum Antibiotic , in Welch, H., and Marti-Ibanez, F. (eds): Antibiotics Annual 1958-59, New York: Medical Encyclopedia, Inc., 1959, pp 505-509.
9.
Koulourides, T.A., and Buonocore , M.G.: Effect of Organic Ions on Solubility of Enamel and Dentin in Acid Buffers, J Dent Res40:578-593, 1961.
10.
Hunt, D.E.; Pittillo, R.F.; Johnson, E.P.; and Moncrief, F.C.: The Effect of Actinobolin on Nucleic Acid and Protein Synthesis in Escherichia coli, Canad J Microbiol12:515-520, 1966.
11.
Harris, R.S. , and Navia, J.M.: Influences of Vehicles and Routes of Administration on the Effectiveness of Agents in the Prevention of Oral Disease in Experimental Animals, Ann NY Acad Sci153:240-257, 1968.
