Rodent Model Systems in Periodontal Disease Research

Keyes, P.H. : Dental Caries in the Syrian Hamster. 1. The Character and Distribution of Lesions, J Dent Res 25:341-353, 1946.

Mitchell, D.F. , and Johnson, M.J. : The Nature of the Gingival Plaque in the Hamster-Production, Prevention, and Removal, J Dent Res 35:651-655, 1956.

Keyes, P.H. , and Jordan, H.V. : Periodontal Lesions in the Syrian Hamster. III. Findings Related to an Infectious and Transmissible Component, Arch Oral Biol 9:377-400, 1964.

Jordan, H.V. , and Keyes, P.H. : Aerobic, Gram-Positive, Filamentous Bacteria as Etiologic Agents of Experimental Periodontal Disease in Hamsters, Arch Oral Biol 9:401-414, 1964.

Howell, A. , JR.: A Filamentous Microorganism Isolated from Periodontal Plaque in Hamsters. I. Isolation, Morphology, and General Cultural Characteristics, Sabouraudia 3:81-92, 1963.

Howell, A., JR. , and Jordan, H.V. : A Filamentous Microorganism Isolated from Periodontal Plaque in Hamsters. II. Physiological and Biochemical Characteristics , Sabouraudia 3:93-105, 1963.

Howell, A., JR. ; Jordan, H.V. ; Georg, L.K. ; and Pine, L. : Odontomyces viscosus, gen. nov., spec. nov., a Filamentous Microorganism Isolated from Periodontal Plaque in Hamsters, Sabouraudia 4:65-68, 1965.

Georg, L.K. ; Pine, L. ; and Gerenczer, M.A. : Actinomyces viscosus, comb nov., a Catalase Positive, Facultative Member of the Genus Actinomyces, Int J Syst Bacteriol 19:291-293, 1969.

Stewart, W.H. , and Burnett, G.W. : The Relationship of Certain Dietary Factors to Calculus-like Formation in Albino Rats, J Periodont 31:7-18, 1960.

Konig, K.G. , and Muhlemann, H.R. : Alterations in Rat Gingiva Due to Plaque Accumulations, Helv Odont Acta 3:44-48, 1959.

Thilander, H. : Periodontal Disease in the White Rat. Experimental Studies with Special Reference to Some Aetiologic and Pathologic Features, thesis, Trans Roy Sch Dent Stockholm No. 6, 1961.

Gupta, O.P. , and Shaw, J.H. : Periodontal Disease in the Rice Rat. I. Anatomic and Histopathologic Findings, Oral Surg 9 :592-603, 1956.

Gupta, O.P. ; Auskaps, A.M. ; and Shaw, J.H. : Periodontal Disease in the Rice Rat. IV. The Effects of Antibiotics on the Incidence of Periodontal Lesions, Oral Surg 10:1169-1175, 1957.

Dick, D.S. , and Shaw, J.H. : The Infectious and Transmissible Nature of the Periodontal Syndrome of the Rice Rat, Arch Oral Biol 11:1095-1108, 1966 .

Dick, D.S. ; Shaw, J.H. ; and Socransky, S.S. : Further Studies on the Microbial Agent or Agents Responsible for the Periodontal Syndrome in the Rice Rat, Arch Oral Biol 13:215-228, 1968.

Jordan, H.V. ; Fitzgerald, R.J. ; and Stan-Ley , H.R. : Plaque Formation and Periodontal Pathology in Gnotobiotic Rats Infected with an Oral Actinomycete , Amer J Path 6:1157-1167, 1965 .

Gibbons, R.J. ; Berman, K.S. ; Knoettner , P. ; and Kapsimalis , B. : Dental Caries and Alveolar Bone Loss in Gnotobiotic Rats Infected with Capsule Forming Streptococci from Human Carious Lesions, Arch Oral Biol 11:549-560, 1966.

Gibbons, R.J. , and Banghart, S. : Induction of Dental Caries in Gnotobiotic Rats with a Levan-forming Streptococcus and a Streptococcus Isolated from Subacute Endocarditis, Arch Oral Biol 13:297-308, 1968.

Socransky, S.S. : Relationship of Bacteria to the Etiology of Periodontal Disease, J Dent Res 99:(suppl): 203-222, 1970.

Gustafsson, B.E. : Use of Laboratory Animals. Choice of Animal and Problems Involved, Ann NY Acad Sci 153:206-211, 1968.

Shafer, W.G. : Use of Laboratory Animals for Periodontal Studies, Ann NY Acad Sci 153:223-229, 1968.

Shaw, J.H. : Critique and Value of Animal Experimentation, Ann NY Acad Sci 153: 265-275, 1968.

McPherson, C.W. : Program Chairman Symposium: Animal Models for Biomedical Research , NAS Publication 1594, Washington, DC, 1968 .

Lindsey, J.R. : Program Chairman Symposium : Animal Models for Biomedical Research . 11, NAS Publication 1736, Washington, DC, 1969.

Frenkel, J.K. : Pathology Society Symrosium on Choice of Animal Models for the Study of Disease Processes in Man. Introduction, Fed Proc 28:160-215, 1969.

Leader, R.W. : Discovery and Exploitation of Animal Model Diseases, in Pathology Society Symposium on Living Models for the Study of Disease Processes in Man, Fed Proc 78:1804-1809, 1969.

Gay, W.I. (ed): Methods of Animal Experimentation, Vol 3, New York, Academic Press , 1968.

Gustafsson, G. ; Stelling, E. ; and Bru-Nius, E. : The Use of Animals in Dental Research, in Gay, W.I. (ed): Methods of Animal Experimentation, New York, Academic Press, 1968.

Russell, W.M.S. , and Burch, R.L. : The Principles of Humane Experimental Technique, London : Methuen Co., Ltd., 1959 .

Mitchell, D.F. : Periodontal Disease in the Syrian Hamster , JADA 49:177-183, 1954.

Costich, E.F. : The Histopathologic Reaction of the Gingiva in Hamster Periodontal Disease, abstracted, J Dent Res 34:680, 1955.

Gold, H.S. , and Keyes, P.H. : Periodontal Lesions in the Syrian Hamster. II. Observations in the Influence of Sex and the Effect of Preweaning Rations, Oral Surg 8 :1060-1062, 1955.

Jordan, H.V. ; Keyes, P.H. ; and Lim , S. : Plaque Formation and Implantation of Odontomyces viscosus in Hamsters Fed Different Carbohydrates , J Dent Res 48 :824-831, 1969.

Keyes, P.H. , and Jordan, H.V. : The Effect of Two Diets and an Antibiotic on Periodontal Disease in Hamsters, abstracted, IADR Program of Abstracts and Papers, No. 67, 1965 .

Mergenhagen, S.E. ; Temple, T.R. ; and Snyderman , R. : Immunologic Reactions and Periodontal Inflammation, J Dent Res 49:256-261, 1970.

Fitzgerald, R.J. ; Jordan, H.V. ; and Stan-Ley , H.R. : Experimental Caries and Gingival Pathology in the Gnotobiotic Rat, J Dent Res 39:923-925, 1960.

Baer, P.N. , and Mcclure, F.J. : Observations on Alveolar Bone Resorption in Rodents Fed a Diet Containing Ground Whole Oats, abstracted, J Dent Res 40:656, 1961.

Gerenczer, M.A. , and Slack, J.M. : Identification of Human Strains of Actinomyces viscosus, Appl Microbiol 18:80-87, 1969.

Jordan, H.V. , and Bellack : Unpublished data.

Mitchell, D.F. , and Chernausek, D.S. : Two Studies of Periodontal Disease in the Syrian Hamster, J Dent Res 30:802-805, 1951.

Keyes, P.H. : Research in Dental Caries, JADA 76:1357-1373, 1968.

Keyes, P.H. ; Rowberry, S.A. ; Englander , H.R. ; and Fitzgerald , R.J. : Bio-Assays of Medicaments for the Control of Dentobacterial Plaque, Dental Caries, and Periodontal Lesions in Syrian Hamsters, J Oral Ther 3:157-173, 1966.

Schneierson, S.S. , and Perlman, E. : Toxicity of Penicillin for the Syrian Hamster , Proc Soc Exp Biol Med 91:229-230, 1956.

Fitzgerald, R.J. , and Keyes, P.H. : Attempted Immunization of Albino Hamsters Against Induced Dental Caries, abstracted, IADR Program of Abstracts and Papers, No. 146, 1962.

Wagner, M. : A Study of the Effects of Specific Immunization on Experimental Dental Caries in the Gnotobiotic Rat, thesis, Purdue University , 1966.

Bahn, A.N. ; Pinter, J.K. ; Quillman, P.D. ; and Hayashi, J.A. : Immunization with Enzymes Against Caries in the Rat, IADR Program of Abstracts and Papers, No. 64, 1969.

Gaffar, A. ; Marcussen, H.W. ; Ruffner, J. ; and Kestenbaum, R.C. : Effects of Specific Immunization on Experimental Dental Caries in Hamsters, abstracted, IADR Program of Abstracts and Papers, No. 304, 1970.

Tanzer, J.M. ; Hageage, G.J. ; and Larson, R.H. : Inability to Immunologically Protect Rats Against Smooth Surface Caries, abstracted, IADR Program of Abstracts and Papers, No. 466, 1970.