Formation and Accumulation of Acid on the Tooth Surface

Stephan, R.M. , and Miller, B.F. : A quantitative Method for Evaluating Physical and Chemical Agents which Modify Production of Acids in Bacterial Plaques on Human Teeth, J Dent Res 22:45-51, 1943.

Von Bertalanffy, L. : General System Theory: Foundations, Development, Applications, New York: George Braziller Inc., 1968.

Bray, H.G. , and White, K. : Kinetics and Thermodynamics in Biochemistry, 2nd ed, New York: Academic Press, 1966, pp 197-204.

, Stephan, R.M. : Changes in Hydrogen-Ion Concentration on Tooth Surfaces and in Carious Lesions, JADA 27:718-723, 1940.

Stephan, R.M. : Intra-oral Hydrogen-Ion Concentrations Associated with Dental Caries Activity , J Dent Res 23:257-266, 1944.

Strålfors, A. : Investigations into the Bacterial Chemistry of Dental Plaques, Odont T 58:153-341, 1950.

Sillen, L.G. : Treatise on Analytical Chemistry. Part I. Theory and Practice, Kolthoff, I.M. and Elving, P.J. , (eds), New York: Interscience , 1959, p 277.

Kleinberg, I. : Studies on Dental Plaque. I. The Effect of Different Concentrations of Glucose on the pH of Dental Plaque In Vivo, J Dent Res 40:1087-1111, 1961.

Kleinberg, I. : Effect of Urea Concentration on Human Plaque pH Levels In Situ, Arch Oral Biol 12:1475-1484, 1967.

Kleinberg, I. : Biochemistry of the Dental Plaque, in Staple, P.H. (ed): Advances Oral Biol, Vol 4, New York: Academic Press, 1970, p 43.

Kleinberg, I. , and Jenkins, G.N. : The pH of Dental Plaques in the Different Areas of the Mouth Before and After Meals and their Relationship to the pH and Rate of Flow of Resting Saliva, Arch Oral Biol 9:493-516, 1964.

Singer, D.L. , and Kleinberg, I. : NH3 Formation in Plaque In Situ, abstracted IADR, Program and Abstracts of Papers, No. 637, 1969.

Lamer, V.K. , and Healy, T.W. : Adsorption-Flocculation Reactions of Macromolecules at the Solid-Liquid Interface, Rev Pure Appl Chem 13:112-133, 1963.

Silverman, G. , and Kleinberg, I. : Studies on Factors Affecting the Aggregation of the Microorganisms in Human Dental Plaque, Arch Oral Biol 12:1407-1416, 1967.

Nevin, R.B. : The Diet and Mastication; Their Effects on Diffusion and on the Inception of Dental Caries, Dunedin: Progress Printing Co., Ltd. 1954.

Halhoul, M.N. , and Kleinberg, I. : Catabolism of Glucose, Fructose, Sucrose, Dextrans and Levans in a Salivary Sediment System, abstracted IADR Program and Abstracts of Papers, No. 383 , 1969.

Wood, J.M. : The State of Hexose Sugar in Human Dental Plaque and its Metabolism by the Plaque Bacteria, Arch Oral Biol 14:161-168, 1969.

Korayem, M. , and Kleinberg, I. : Effect of pH on Glucose Utilization and Acid Formation by Salivary Sediment, abstracted IADR Program and Abstracts of Papers, No. 586, 1970 .

Kleinberg, I. : Dental Caries, in Nolte, W.A. (ed): Oral Microbiology St. Louis, C.V. Mosby, Chap 8, 1968.

Kleinberg, I. , and Jenkins, G.N. : Further Studies on the Effect of Carbohydrate Substrates on Plaque pH In Vivo, J Dent Res 38:704-705, 1959.

Kleinberg, I. : Studies on the Influence of Diet on the Dental Plaque with Special Reference to the Initiation of Caries, PhD thesis, University of Durham, England, 1958.

Ludwig, T.G. , and Bibby, B.G. : Acid Production from Different Carbohydrate Foods in Plaque and Saliva, J Dent Res 36:56-60, 1957.

Caldwell, R.C. , and Bibby, B.G. : The Effect of Foodstuffs on the pH of Dental Cavities, JADA 57:685-692, 1958.

Dirksen, T.R. ; Little, M.F. ; Bibby, B.G. ; and Crump, S.L. : The pH of Carious Cavities. I. The Effect of Glucose and Phosphate Buffer on Cavity pH, Arch Oral Biol 7:49-58, 1962.

Deboever, J. , and Mühlemann, H.R. : pH of Interproximal Plaque with Regard to Continuous Sucrose Application, Helv Odont Acta 13:97-99, 1969.

Koulourides, T. ; Feagin, F. ; and Pigman, W. Remineralization of Dental Enamel by Saliva In Vitro, Ann NY Acad Sci 131: 751-757, 1965.

Hemmens, E.S. ; Blayney, J.R. ; Bradel, S.F. ; and Harrison , R.W. The Microtic Flora of the Dental Plaque in Relation to the Beginning of Caries, J Dent Res 25: 195-205, 1946.

Becks, H. ; Jensen, A.L. ; and Millarr, C.B. : Rampant Dental Caries: Prevention and Prognosis. A Five Year Clinical Survey , JADA 31:1189-1200, 1944 .

Welander, E. : The Occurrence of Dental Caries in the Permanent Dentition, Uppsala : Almqvist and Wiksells, 1955, pp 94-117.

Stephan, R.M. : Hydrogen Ion Concentration of the Dental Plaque , J Dent Res 17: 251-256, 1938.

Anderson, B.G. : Clinical Study of Arresting Dental Caries, J Dent Res 17:443-452, 1938.

Stephan, R.M. , and Hemmens, E.S. : Studies of Changes in pH Produced by Pure Cultures of Oral Micro-organisms, J Dent Res 26:15-41, 1947.

Miller, B.F. ; Muntz, J.A. ; and Bradel, S. Decomposition of Carbohydrate Substrates by Dental Plaque Material. J Dent Res 19:473-478, 1940.

Volker, J.F. , and Pinkerton, D.M. : Acid Production in Saliva-Carbohydrate Mixtures, J Dent Res 26:229-232, 1947.

Erichsen, A. , and Schulerud, A. : Forskjellige brödsorters klebrighet under tyggningen, Odont T 50:221, 1942, cited by Lanke, L.S. : Influence on Salivary Sugar of Certain Properties of Foodstuffs and Individual Oral Conditions , Acta Odont Scand 15 (suppl 23):1957.

Onisi, M. , and Kondo, W. : Establishing an Environment for Growth of Aciduric Bacteria in the Oral Cavity , J Dent Res 35:596-602, 1956.

Gibbons, R.J. , and Socransky, S.S. : Intracellular Polysaccharide Storage by Organisms in Dental Plaques. Its Relation to Dental Caries and Microbial Ecology of the Oral Cavity, Arch Oral Biol 7:73-80, 1962.

Kleinberg, I. : Effect of Varying Sediment and Glucose Concentrations on the pH and Acid Production in Human Salivary Sediment Mixtures, Arch Oral Biol 12:1457-1473, 1967.

Singer, D.L. , and Kleinberg, I. : Cell concentration and the pH of Suspended Plaque Mixtures In Vitro, abstracted, IADR Program and Abstracts of Papers, No. 494, 1970.

Sandham, H.J. , and Kleinberg, I. : Utilization of Glucose and Lactic Acid by Salivary Sediment, Arch Oral Biol 14:597-602, 1969.

Hu, G. , and Sandham, H.J. : Lactic Acid Utilization by Streptococci, abstracted, IADR Program and Abstracts of Papers, No. 173, 1969.

Muntz, J.A. : Production of Acids from Glucose by Dental Plaque Material, J Biol Chem 148:225-236, 1943.

Sandham, H.J. , and Kleinberg, I. : Contribution of Lactic and Other Acids to the pH of a Salivary Sediment System during Glucose Catabolism, Arch Oral Biol, in press, 1970.

Kleinberg, I. : Craw, D. ; and Kay. M. : The Effect of a Salivary pH-Rise Factor on Salivary Sediment Metabolism, abstracted IADR Program and Abstracts of Papers, No. 90, 1968.

Lilienthal, B. : An Analysis of the Buffer Systems in Saliva , J Dent Res 34:516-530, 1955.

Holt, L.E., JR. ; La Mer, V.K. ; and Chown, H.B. : Studies in Calcification. I. The Solubility Product of Secondary and Tertiary Calcium Phosphate under Various Conditions , J Biol Chem 64:509-565, 1925.

Jenkins, G.N. : The Effect of pH on the Fluoride Inhibition of Salivary Acid Production, Arch Oral Biol 1:33-41, 1959.

Kleinberg, I. : Regulation of the Acid-Base Metabolism of the Dento-Gingival Plaque and Its Relation to Dental Caries and Periodontal Disease, Int Dent J, in press, 1970.

Gilmour, M.N. , and Poole, A.E. : The Fermentative Capabilities of Dental Plaque, Caries Res 1:247-260, 1967.

Sandham, H.J. , and Kleinberg, I. : The Effect of Fluoride on the Interrelation Between Glucose Utilization, pH and Carbohydrate Storage in a Salivary Sediment System, Arch Oral Biol 14:619-628, 1969.

Craw, D. , and Kleinberg, I. : Effect of Salivary Supernatant and Fluoride on the Metabolism of Glucose in a Salivary Sediment System, abstracted IADR Program Abstracts of Papers, No. 385, 1969.

Kleinberg, I. ; Kay, M. ; and Craw, D. : Saliva in the Regulation of the pH of Salivary Sediment During Urea Utilization, abstracted IADR Program and Abstracts of Papers, No. 382, 1969.

Krasse, B. , and Carlsson, J. : Various Types of Streptococci and Experimental Caries in Hamsters, Arch Oral Biol 15:25-32, 1970.

Eggers-Lura, H. : Untersuchungen über den aeroben und anaeroben Abbau der Kohlehydrate im Speichel, Deutsch Zahn Mund Kieferheilk 21:97-111, 1954.

Miller, W.D. : The Micro-Organisms of the Human Mouth, Philadelphia: S.S. White Dental Mfg Co., 1890.

Korayem, M. , and Kleinberg, I. : Studies on the Effect of Glucose and Salivary Supernatant on the Uptake of Oxygen by the Mixed Microbial Flora in a Suspended Salivary Sediment System Using the Clark Oxygen Electrode, Arch Oral Biol, submitted for publication, 1970.

Hartles, R.L. , and Wasdell, M. : The Metabolism of the Oral Flora. 6. Preliminary Observations on a Water-Soluble Factor in Saliva which Enhances the Respiratory and Glycolytic Activity of the Salivary Flora, Brit Dent J 98:334-337, 1955.