A significantly increased uptake of 65Zn administered intravenously was detected in healing bones of rats compared with control rats. The parameters used for measuring osteogenesis included: histologic examination, radiographic studies, and Ca 45 uptake in bone. The accumulation of 65Zn appeared to be correlated with bone formation. The data suggest a mobilization of zinc to the site of bone repair.
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References
1.
Savlo, E.D.; Strain, W.H.; and Huegin, F.: Radio-Zinc Studies in Experimental Wound Healing, J Surg Res2:209-212, 1962.
2.
Taylor, D.M. : Retention of Zinc-65 in the Bones of Rats , Nature (London)189 :932-943, 1961.
3.
Mahin, D.T., and Lofberg , R.T. : A Simplified Method of Sample Preparation for Determination of Tritium, Carbon-14, or Sulfur-35 in Blood or Tissue by Liquid Scintillation Counting, Anal Biochem16: 500-509, 1966.
4.
Calhoun, N.R. , and Smith, J.C.: Uptake of Zinc65 in Fractured Bones, Lancet2:682-683, 1968.
5.
Vincent, J.: Microscopic Aspects of Mineral Metabolism in Bone Tissue with Special Reference to Calcium, Lead and Zinc, in Depalma, A.F. (ed): Clinical Orthopaedics and Related Research, Philadelphia: J. B. Lippincott Co., 1963, p 161.
6.
Haumont, S., and McLean, D.: Zinc and the Physiology of Bone, in Prasad, A.S. (ed): Zinc Metabolism, Springfield, Ill: Charles C Thomas Co., 1966, p 169.
7.
Hurley, L.S. , and Swenerton, C.: Congenital Malformations Resulting from Zinc Deficiency in Rats, Proc Soc Exp Biol Med123:6, 1966.
8.
O'Dell, B.L.; Newberne, P.M.; and Savage, J.E.: Significance of Dietary Zinc for the Growing Chicken, J Nutr65:503-506, 1958.