3H thymidine was injected intraperitoneally into six male rats on the first, second, and third days after injury to the pulp of the incisors. Forty minutes later the rats were decapitated; the teeth were fixed in formalin and prepared in the usual manner for histoautoradiography. Histologic preparations were stained with hematoxylin and eosin. No odontoblast nuclei labeled by 3H thymidine were observed on the histoautoradiographic pattern. After pulp injury, the odontoblasts behaved as irreversible postmitotic cells incapable of DNA synthesis.
Pinzon, R.O. ; Toto, P.D.; and O'Mal-Ley , J.: Kinetics of Rat Molar Pulp Cells at Various Ages, J Dent Res45:934-938, 1966.
8.
Tonna, E.A., and Cronitte, E.P.: Cellular Response to Fracture Studied with Tritiated Thymidine, J Bone Joint Surg43:352-362, 1961.
9.
Sween, O.B., and Hawes, R.R.Differentiation of new Odontoblasts and Dentine Bridge Formation on Rat Molar Teeth after Tooth Grinding, Arch Oral Biol13: 1399-1412, 1968.
