Actinobolin was tested by a paper disk-agar diffusion method for inhibitory activity against cariogenic streptococcal strains, mixed microbial cultures, bacteria, and yeasts. The cariogenic streptococci and the mixed cultures were highly sensitive to inhibition by actinobolin, which suggests that this antibiotic may be useful as a cariostatic agent.
Get full access to this article
View all access options for this article.
References
1.
Mitchell, D.F. , and Holmes, L.A.: Topical Antibiotic Control of Dentogingival Plaque, J Periodont36:202-207, 1965.
2.
Volpe, A.R.; Kupczak, L.J.; Brant, J.H.; Kestenbaum, R.C.; and Schlissel, H.J.: Antimicrobial Control of Bacterial Plaque and Calculus and the Effects of these Agents on Oral Flora, J Dent Res48 :832-841, 1969.
3.
Hill, T.J., and Kneisner, A.H.: Penicillin Dentifrice and Dental Caries Experience in Children, J Dent Res28:263-266, 1949.
4.
Zander, H.A. : Effect of a Penicillin Dentifrice on Caries Incidence in School Children, IADA40:569-574, 1950.
5.
Carney, R.G. : Topical Use of Antibiotics. JAMA186:646-648, 1963.
6.
Pittillo, R.F.; Fisher, M.W.; McAlpinf, R.J.; Thompson, P.E.; and Ehrlich, J.: "Actinobolin, a New Broad-Spectrum Antibiotic," in Welch, H., and Marti-Ibañez, F. (eds), Antibiotics Annual 1958-1959, New York: Medical Encyclopedia Inc., 1959, pp 497-504.
7.
Merker, P.C., and Woolley, G.W.: "The Effects of Actinobolin on Human Epidermoid Carcinoma (H. Ep. No. 3) (Growing in the Conditioned Swiss Mouse," in Welch, H., and Marti-Ibañez, F. (eds), Antibiotics Annual 1958-1959, New York: Medical Encyclopedia, Inc., 1959, pp 515-517.
8.
Hunt, D.E., and Pittillo, R.F.: "Antimicrobial Activity of 1,2,5,-selenadiazoles," in Hobby, G.L. (ed), Antimicrobial Agents and Chemotherapy, 1966, Ann Arbor, Mich.: American Society for Microbiology, 1967, pp 551-554.
9.
Jablon, J.M. , and Zinner, D.D.: Differentiation of Cariogenic Streptococci by Fluorescent Antibody, J Bacteriol92: 1590-1596, 1966.
10.
Gibbons, R.J. ; Berman, K.S.; Knoett-Ner , P.; and Kapsimalis , B.: Dental Caries and Alveolar Bone Loss on Gnotobiotic Rats Infected with Capsule Forming Streptococci of Human Origin, Arch Oral Biol11:549-559, 1966.
11.
Fitzgerald, R.J., and Keyes, P.H.: Demonstration of the Etiologic Role of Streptococci in Experimental Caries in the Hamster, J ADA61:9-13, 1960.
12.
Hunt, D.E.; Pittillo, R.F.; Johnson, E.P.; and Moncrief, F.C.: The Effect of Actinobolin on Nucleic Acid and Protein Synthesis in Escherichia coli, Can J Microbiol12:515-520, 1966.
