Effect of Alcohol and Cigarette Smoke as Promoting Agents in Hamster Pouch Carcinogenesis

Abstract

In a series of young Syrian hamsters, pouch carcinogenesis initiated by application of 7, 12-dimethylbenz(a)anthracene (DMBA) to cheek epithelium was augmented by subsequent application of alcohol or applied whole cigarette smoke or both. These findings support previous reports that smoke and alcohol act individually as promoting agents in experimental oral carcinogenesis. Neither locally applied alcohol nor applied whole cigarette smoke acted as co-carcinogens or carcinogens on hamster pouch epithelium. Under conditions of this study, whole cigarette smoke appeared to be a more potent promoting agent than locally applied alcohol, as evaluated clinically and histologically.

Get full access to this article

View all access options for this article.

References

Goldhaber, P. : The Role of Saliva and Other Local Environmental Factors in Oral Carcinogenesis , JADA 54:517, 1957.

Kreshover, S.J. , and Salley, J.J. : Predisposing Factors in Oral Cancer, JADA 54:509, 1957.

Wynder, E.L. ; Bross, I.J. ; and Feldman, R.M. : A Study of Etiological Factors in Cancer of the Mouth, Cancer 10:1300, 1957.

Smoking and Health , Report of the Advisory Committee to the Surgeon General of the Public Health Service Washington, DC, 1964.

Salley, J.J. : Smoking and Oral Cancer, J Dent Res 42:328, 1963.

Elzay, R.P. : Local Effect of Alcohol in Combination with DMBA on Hamster Cheek Pouch, J Dent Res 45:1788, 1966.

Salley, J.J. : Experimental Carcinogenesis in Cheek Pouch of the Syrian Hamster, J Dent Res 33:253, 1954.

Elzay, R.P. : Dimethyl Sulfoxide and Experimental Oral Carcinogenesis in the Hamster Pouch , Arch Path 83:293, 1967.

Kreshover, S.J. : The Effect of Tobacco on Epithelial Tissues of Mice, JADA 45:528, 1952.

10.

Ketcham, A.S. ; Wexler, H. ; and Mantel, N. : Effect of Alcohol in Mouse Neoplasia, Cancer Res 23:667, 1963

11.

Epstein, S.S. : Carcinogenicity of Organic Extracts of Atmospheric Pollutants, J Air Pollut Contr Ass 17:728, 1967.