A comparative quantitative analysis was made of the mast cell population in Mikulicz's recurrent oral aphthae of varying duration with the mast cell population in normal mucosa. There was a reduction in the number of mast cells with increasing age of the lesion. The significance of these findings in relation to the etiology of the disease is discussed.
Get full access to this article
View all access options for this article.
References
1.
Mikulicz, J. Von, and Kummel, W.: Die Krankheiten des Mundes, Jena, 1888.
2.
Lehner, T.: Recurrent Aphthous Ulceration and Autoimmunity, Lancet II7370: 1154-1155, 1964.
3.
Lehner, T.: Aphthous Ulceration of the Mouth and Autoimmunity, Guy's Hosp Gaz79:179-782, 1965.
4.
Graykowski, E.A.; Barile, M.F.; Boyd Lee, W.; and Stanley, R.: Recurrent Aphthous Stomatitis. Clinical, Therapeutic, Histopathologic and Hypersensitivity Aspects, JAMA196:637-644, 1966.
5.
Stuart, E.G. : Mast Cell Responses to Anaphylaxis, Anat Rec112:394, 1952.
6.
Keller, R.: Mast Cells and Anaphylaxis, Experimentia (Basel)18:286-288, 1962.
7.
Archer, G.T.: Release of 5-hydroxytryptamine from Rat Mast Cells In Vitro, Nature (London)190:350, 1961.
8.
Mota, I.: Action of Anaphylactic Shock and Anaphylatoxin on Mast Cells and Histamine in Rats, Brit J Pharmacol12: 453-456, 1957.
9.
Mota , I., and Dias DASilva, W.: Antigen-Induced Damage to Isolated Sensitized Mast Cells, Nature (London)186:245-246, 1960.
10.
Boreus, L.O. , and Chakravarty, N.: The Histamine Content of Guinea Pig Mast Cells, Experientia (Basel)16:192, 1960.
11.
Bower, D., and Chadwin, C.G.: Simultaneous Demonstration of Mast Cells and Plasma Cells, J Clin Path19:298-299, 1966.
12.
Gell, P.G.H., and Coombs, R.R.A.: Clinical Aspects of Immunology, Oxford: Black-well Scientific Publications, 1963, pp 317-337.
13.
Inderbitzin, T.: The Mechanisms Involved in Histamine Release and Histamine Increase in Allergic Skin Reactions, Int Arch Allergy18:85-99, 1961.
14.
Prochazka Fisher, J., and Cooke, R.A.: Experimental Toxic and Allergic Contact Dermatitis: I. A Chemical Study of Histamine Content, J Allergy29:396-410, 1958.
15.
Padawer, J.: Quantitative Studies with Mast Cells, Ann NY Acad Sci103:87-183, 1963.
16.
Arvy, L.: Les Labrocytes, l'héparine et l'histamine, Ann Biol32:169-202, 1956.
