Correlated morphological and thymidine-3H autoradiographic observations on dentinogenesis in lower incisor roots and osteogenesis in the associated alveolar bone of young rats were made with the electron microscope. The results support the concept that proliferating osteogenic and dentinogenic cells may undergo two alternative types of cytodifferentiation: fibrogenic and resorptive.
Get full access to this article
View all access options for this article.
References
1.
Cotton, W.R.: Demonstration of Odontoblast Precursor Cell by Tritiated Thymidine, J Dent Res43:810, 1964.
2.
Chiba, M.: Cellular Proliferation in the Tooth Germ of the Rat Incisors, Arch Oral Biol10:707-718, 1965.
3.
Hunt, A.M., and Paynter, K.J.: Formation of Osteoblasts, Odontoblasts and Osteoclasts, abstracted, J Dent Res40:652, 1961.
4.
Young, R.W.: Cell Proliferation and Specialization during Endochondral Osteogenesis in Young Rats, J Cell Biol14:357-370, 1962.
5.
Tonna, E.A.: The Cellular Complement of the Skeletal System Studied Autoradiographically with Tritiated Thymidine ('H TDR) during Growth and Aging, J Biophys Biochem Cytol9:813-824, 1961.
6.
Scott , B.L.: Thymidine-'H Electron Microscope Radioautography of Osteogenic Cells in the Fetal Rat, J Cell Biol35:115-126, 1967.
7.
Pease, D.C.: Buffered Formaldehyde as a Killing Agent and Primary Fixative for Electron Microscopy, abstracted, Anat Rec142:362, 1962.
8.
Millonig, G. : A Modified Procedure for Lead Staining of Thin Sections, J Biophys Biochem Cytol11:736-739, 1961.
Venable, J.H. , and Coggeshall, R.A.: A Simplified Lead Stain for Use in Electron Microscopy, J Cell Biol25:407-408, 1965.
11.
Fitton Jackson, S.: "Connective Tissue Cells," In Brachet, J., and Mirsky A. E. (eds.), The Cell, vol. 6, chap 6, New York: Academic Press, Inc., 1964, pp 387-520.
12.
Pritchard, J.J. : "The Osteoblast," in Bourne, G.H. (ed.), The Biochemistry and Physiology of Bone, chap 7, New York: Academic Press, Inc., 1956, pp 179-212.
13.
Cohn, Z.A. ; Fedorka, M.E.; and Hirsch, J.G.: The In Vitro Differentiation of Mononuclear Phagocytes: IV. The Ultrastructure of Macrophage Differentiation in the Peritoneal Cavity and in Culture, J Exptl Med125:457, 1966.
14.
Novikoff, A.B.: "Lysosomes and Related Particles," in Brachet, J., and Mirsky, A. E. (eds.), The Cell vol. 2, chap 6, New York: Academic Press, Inc., 1961, pp 423-488.
15.
Greep, R.O.: "Teeth" in Greep, R.O. (ed.), Histology, chap 19, New York: McGraw-Hill, Inc., 1966, pp 466-488.
