In a study of 50 squamous carcinomas of the lower lip, 25 metastasized and 25 were successfully treated by simple resection. Lack of differentiation, a poor lymphocytic response and, in particular, the formation of a loose, alcian blue and Hale positive fibroblastic stroma were unfavorable prognostic signs.
Get full access to this article
View all access options for this article.
References
1.
Jones, J.H. : Squamous Carcinoma of the Lip and Mouth in Northern Ireland, Brit J Cancer, in press, 1969.
2.
Doll, R.; Payne, P.; and Waterhouse , J.: Cancer Incidence in Five Continents, Berlin-Heidelberg- New York: Springer-Verlag, 1966 .
3.
Lynch, G.A.: Cancer of the Lip, Ulster Med J36:44-50, 1967.
4.
Wagner, B.M. , and Smith, D.E.: The Connective Tissue, Baltimore: Williams & Wilkins Co, 1967, pp 296, 303.
5.
Pearse, A.G.E. : Histochemistry, 2nd ed, London: J. & A. Churchill Ltd., 1961, pp 236, 836.
6.
Willis, R.A. : Pathology of Tumours, 2nd ed, London: Butterworth & Co., Ltd., 1953, p 153.
7.
Broders, A.C.: The Microscopic Grading of Cancer, S Clin North America21 :947-962, 1941.
8.
Evans, W.R.: Histological Appearances of Tumours, 2nd ed, Edinburgh and London: E. & S. Livingstone Ltd., 1966, p 947.
9.
Black, M.M.; Opler, S.R.; and Speer, F.D.: Survival in Breast Cancer Cases in Relation to the Structure of the Primary Tumour and Regional Lymph Nodes, Surg Gynec Obstet100:543-551, 1955.
10.
Black, M.M. ; Opler, S.R.; and Speer, F.D.: Structural Representations of Tumour-host Relationships in Gastric Carcinoma , Surg Gynec Obstet102:599-603, 1956.
11.
Alexander, P. , and Fairley, G.H.: Cellular Resistance to Tumours , Brit Med Bull23:86-92, 1967.
12.
Bottiglioni, E., and Prodi, G.: Ricerche sul contenuto in sostanze cromotrope dei tumori in rapporto ol probelma della disseminozione metastatica , Sperimentale107: 150-157, 1957.
13.
Cortesi, C., and Fini-Storchi O.Sul valore prognostico della sostanza metacromatica negli stromi tumorali: Studio su 115 cancri della laringe, Boll Mal Orecchio Gola Naso76:217-238, 1958.
14.
Moore, R.D. ; Stevenson, J.; and Schoen-Berg , M.D.: The Response of Connective Tissue Associated with Tumours of the Skin, Amer J Clin Path34:125-130, 1960.
15.
Majewska, H. ; Majewski, C.; Radzicki , J.; and Leja, Z.: Acid Muco-polysaccharides in the Ground Substance of Connective Tissue in Cancer of the Skin, Cancer18:388-390, 1965.
16.
Gersh, I., and Catchpole, H.R.: The Organization of Ground Substance and Basement Membrane and its Significance in Tissue Injury, Disease and Growth, Amer J Anat85:457-521, 1949.
17.
Coman, D.R. : The Invasive Character of Cancer Growth, Amer J Med Sci211 :257-260, 1946.
18.
McCutcheon, M., and Coman, D.R.: Spreading Factors in Human Carcinomas , Cancer Res7:379-382, 1947.
19.
Vasiliev, J.M. : The Role of Connective Tissue Proliferation in Invasive Growth of Normal and Malignant Tissues: A Review, Brit J Cancer12:524-536, 1958.
Urbach, F.: Anatomy and Pathophysiology of Skin Tumour Capillaries, National Cancer Institute Monograph No. 10, U.S. Department of Health, Education and Welfare, 1963, pp 539-552.
22.
Black, J.W. : The Localization of Metastatic Brown-Pearce Carcinoma in Granulation Tissue, Brit J Cancer18:143-145, 1964.
23.
Takeuchi, J. : Growth Promoting Effect of Acid Mucopolysaccharides on Ehrlich Ascites Tumour, Cancer Res26:797-802, 1966.
