Synthetic contraceptive steroids, ethynylestradiol and medroxyprogesterone acetate, were given individually in different doses to weanling female rats for eight weeks. In proportion to the doses administered, ethynylestradiol inhibited and medroxyprogesterone acetate stimulated the growth and development of the salivary glands. The steroid-treated rats exhibited an increase in dental caries incidence as compared to controls.
Get full access to this article
View all access options for this article.
References
1.
Shafer, W.G. , and Muhler, J.C.: Effect of Gonadectomy and Sex Hormones on the Structure of the Rat Salivary Gland, J Dent Res32:262-268, 1953.
2.
Shafer, W.G. , and Muhler, J.C.: Experimental Dental Caries: III. The Effect of Estradiol and Diethylstilbestrol on Dental Caries, Fluorine Metabolism, and the Salivary Glands of Intact and Gonadectomized Rats, J Dent Res33:842-848, 1954.
3.
Muhler, J.C. , and Shafer, W.G.: Experimental Dental Caries: VII. The Effect of Various Androgens and Estrogens on Dental Caries in the Rat, J Dent Res34 :661-665, 1955.
4.
Liu, F.T.Y. : Effect of Estrone and Estriol on Salivary Glands and Dental Caries in Female Rats, Proc Soc Exp Biol Med124: 591-595, 1967.
5.
Liu, F.T.Y. : Effect of Estrogen, Thyroxin, and Their Combination on Dental Caries and Salivary Glands in Ovariectomized and Intact Female Rats , J Dent Res46:471-477, 1967.
6.
Liu, F.T.Y. , and Lin, H.S.: Effect of Hydrocortisone Acetate on Dental Caries and Salivary Glands in Adrenalectomized Female Rats, J Dent Res47:158-166, 1968.
7.
Liu, F.T.Y. ; Lofgren, R.; and Hoots , I.: Effect of Steroid Hormones on Dental Caries and Salivary Glands in Female Rats, J Dent Res45:1236, 1966.
8.
Liu, F.T.Y. : Influence of Some Steroid Contraceptives on Incidence of Dental Caries and Changes of Salivary Glands in Female Rats, J Dent Res47:1047-1055, 1968 .
9.
Dipalma, J.R.: Drill's Pharmacology in Medicine, 3d ed, New York : McGraw-Hill Book Co., 1965, pp 1103-1106.
10.
Goodman, L.S., and Gilman, A.: The Pharmacological Basis of Therapeutics, 3d ed, New York : Macmillan Co., 1965, pp 1554-1564.
11.
Goodman, L.S., and Gilman, A.: The Pharmacological Basis of Therapeutics, 3d ed, New York : Macmillan Co., 1965, pp 1548-1552.
12.
Larson, R.H. : "Tooth Age and Caries Susceptibility," in Harris, R.S. (ed), Art and Science of Dental Caries Research, New York: Academic Press, Inc., 1968, pp 257-275.
13.
Florsheim, W.H., and Faircloth , M.A.: Effect of Oral Ovulation Inhibitors on Serum Protein-Bound Iodine and Thyroxine Binding Proteins, Proc Soc Exp Biol Med117:56-58, 1964.
14.
Hollander, C.S.; Garcia, A.M.; Sturgis , S.H.; and Selenkow , H.A.: Effect of an Ovulatory Suppressant on the Serum Protein-Bound Iodine and the Red-Cell Uptake of Radioactive Tri-iodothyronine, New Eng J Med269:501-504, 1963.
15.
Alexander, R.W., and Marmorston , J.: Effect of Two Synthetic Estrogens on the Level of Serum Protein-Bound Iodine in Men and Women with Atherosclerotic Heart Disease, J Clin Endocr21:243-251, 1961.
16.
Mestman, J.H. , and Nelson, D.H.: Inhibition by Estrogen Administration of Adrenal-Pituitary Response to Methopyrapone, J Clin Invest42:1529-1534, 1963. 17. Glenn, E.M.; Richardson, S.L.; and Bow-Man, B.J.: Biologic Activity of 6-alphamethyl Compounds Corresponding to Progesterone, 17-alpha-hydroxyprogesterone Acetate and Compound S, Metabolism8: 265-285, 1959.
17.
Steinetz, B.G. ; Beach, V.L.; Dipasquale , G.; and Battista, J.V., JR.: Effects of Different Gestogenic Steroid Types on Plasma-Free Corticosteroid Levels in ACTH-Treated Rats, Steroids5:93-108, 1965.
18.
Holue, D.A.; Katz, F.H.; and Jailer, J.W.: Inhibition by 6-methyl-17-acetoxyprogesterone of ACTH Synthesis and Re
19.
lease in the Rat, Endocrinology68:173-177, 1961.
20.
Sweeney, E.A. , and Shaw, J.H.: The Effect of Adrenalectomy and Cortisone Supplementation on Caries Incidence in Caries-Susceptible Rats , J Dent Res44:96-98, 1965.
21.
Bixler, D.; and Muhler, J.C.: The Relation of Thyroid Gland Activity to the Incidence of Dental Caries in the Rat: II. A Comparison of Caries Incidence under Paired-Feeding Technics , J Dent Res36: 880-882, 1957.
22.
Haldi, J.; Wynn, W.; and Law, M.L.: Relationship between Thyroid Function and Resistance to Dental Caries , J Dent Res41: 398-404, 1962.
23.
Shafer, W.G. ; and Muhler, J.C.: Endocrine Influences upon the Salivary Glands, Ann NY Acad Sci85:215-227. 1960.
