Intact weanling rats were given daily subcutaneous injections of 1.0 mg, 2.0 mg, or 3.0 mg of corticosterone or 0.5 mg of hydrocortisone acetate for 11 weeks. All hormone treatments resulted in a significant decrease in weight and tubular diameter of the submandibular gland. A significant increase in caries incidence was observed in all the hormone-treated rats, except those receiving 1.0 mg of corticosterone. Although corticosterone caused a decrease in thyroid gland weight, the protein-bound iodine (PBI) levels of the treated rats were normal. This indicated that corticosterone-induced increase in caries incidence and interference with the salivary gland integrity were not due to the decreased thyroid function.
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References
1.
Liu, F.T.Y., and Lin, H.S.: Effect of Hydrocortisone Acetate on Dental Caries and Salivary Glands in Adrenalectomized Female Rats, J Dent Res47:158-166, 1968.
Sweeney, E.A. , and Shaw, J.H.: The Effect of Adrenalectomy and Cortisone Supplementation on Caries Incidence in Caries-Susceptible Rats , J Dent Res44:96-98, 1965. 4. Sutton, P.R.N.: "Stress and Dental Caries," in Staple, P.H. (ed): Advances in Oral Biology, New York: Academic Press, Inc., 1966, Vol 2, p 121.
4.
Sutton, P.R.N. : Mental Stress and Acute Dental Caries, Nature195:254-256, 1962. 6. Manhold, J.H., JR., and Hafner, A.J.: Dental Caries and Psychological Factors, J Clin Psychol14:319-321, 1958.
5.
Steinman, R.R. ; Brussett, M.; and Tar-Taryn, P.: Comparison of Caries Incidence in Exercised and Immobilized Rats, J Dent Res40:218, 1961.
6.
Manhold, J.H. , JR.: A Pilot Experiment Employing Animals for the Study of Dental Psychosomatic Tenets, New York J Dent28:343-344, 1958.
7.
Nichols, W.A. : Psychologic Stress Effect on Adrenal and Salivary Glands and Dental Caries in the Rat, abstracted, IADR Preprinted Abstracts, No. 399, 1968.
8.
Bush, I.E.: Paper-Chromatographic Study of the Secretion of the Adrenal Cortex in Various Mammalian Species, J Physiol115: 12P-13P, 1951.
9.
Nelson, D.H. , and Samuels, L.T.: A Method for the Determination of 17-Hydroxycorticosteroids in Blood. 17-Hydroxy-corticosterone in the Peripheral Circulation. J Clin Endocr12:519-529, 1952.
10.
Eik-Nes, K.; Nelson, D.H.; and Samuels, L.T.: Determination of 17, 21-Hydroxy-corticosteroids in Plasma, J Clin Endocr13:1280-1282, 1953 .
11.
Shafer, W.G. , and Muhler, J.C.: Endocrine Influences upon the Salivary Glands, Ann NY Acad Sci85:215-227, 1960.
12.
Haldi, J.; Wynn, W.; and Law, M.L.: Relationship between Thyroid Function and Resistance to Dental Caries , J Dent Res41:398-404, 1962.
13.
Money, W.L. ; Kraintz, L.; Fager , J.; Kirschner, L.,; and Rawson, R.W.: The Effects of Various Steroids on the Collection of Radioactive Iodine by the Thyriod Gland of the Rat, Endocrinology48 :682-690, 1951.
14.
Pitt-Rivers, R., and Trotter, W.R.: The Thyroid Gland, London: Butterworth & Co., 1964 , Vol 2, p 7.
15.
Hill, S.R., JR.; Reiss, R.S.; Forsham, P.H.; and Thorn, G.W.: The Effect of Adrenocorticotropin and Cortisone on Thyroid Function: Thyroid-Adrenocortical Interrelationships, J Clin Endocr10:1375-1400, 1950.
16.
Bixler, D., and Muhler, J.C.: The Relationship of Food Consumption and Salivary Flow to the Incidence of Dental Caries, J Dent Res37:407-409, 1958.
17.
Mann, A.W.; Dreizen, S.; Spies, T.D.; and Hunt, F.M.: A Comparison of Dental Caries Activity in Malnourished and Well-Nourished Patients, JADA34:244-252, 1947.
18.
Russell, A.L. : International Nutrition Surveys : A Summary of Preliminary Dental Findings, J Dent Res42:233-244, 1963. 21. Steinman, R.R.; Hardinge, M.G.; and Woods, R.W.: Experimental Caries with Human Foods, J Dent Res37:865-873. 1958.
