A tetracycline labeling method was used for demonstration of bone-remodeling changes in both tibias following unilateral local X irradiation of the mandible and tibia. A 5-mm diameter X-ray beam was used. Direct effects of 4,500 and 9,000 R exposures of two different radiation qualities were evaluated quantitatively. An assessment of the abscopal effect was also made.
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References
1.
Leblond, C.P.; Wilkinson, G.W.; Belan-Ger, L.F.; and Robichon, J.: Radioautographic Visualization of Bone Formation in the Rat, Amer J Anat86:289-341, 1950.
2.
Tomelin, D.H. ; Henry, K.M.; and Kon , S.K.: Autoradiographic Study of Growth and Calcium Metabolism in the Long Bones of the Rat, Brit J Nutr7:235-252, 1953.
3.
Enlow, D.H.: Principles of Bone Remodeling, Springfield, Ill. : Charles C Thomas, 1963, p 23.
4.
Frost, H.M.: Bone Remodeling Dynamics, Springfield, Ill.: Charles C Thomas, 1963, p 175.
5.
Milch, R.A.; Rall, D.P.; and Tobie, J.E.: Bone Localization of the Tetracyclines, J Nat Cancer Inst19:87-93, 1957.
6.
Milch, R.A.; Rall, D.P.; and Tobie, J.E.: Fluorescence of Tetracycline Antibiotics in Bone, J Bone Joint Surg40-A:897-910, 1958.
7.
Frost, H.M., and Villanueva, A.R. : Tetracycline Staining of Newly Forming Bone and Mineralizing Cartilage In Vivo, Stain Techn35:135-138, 1960.
8.
Frost, H.M.: Measurement of Human Bone Formation by Means of Tetracycline Labeling , Canad J Biochem41:31-42, 1963.
9.
Frost, H.M.; Villanueva, A.R.; and Roth, H.: Measurement of Bone Formation in a 57-Year-Old Man by Means of Tetracyclines , Henry Ford Hosp Med Bull8: 239-254, 1960.
10.
Frost, H.M. : Human Osteoblastic Activity: II. Measurement of the Biological Half-Life of Bones with the Aid of Tetracyclines, Henry Ford Hosp Med Bull9:87-96, 1961.
11.
Frost, H.M. : Mean Formation Time of Human Osteons, Canad J Biochem41 :1307-1310, 1963 .
12.
Taylor, T.C. ; Epker, B.N.; and Frost, H.M.: The Appositional Rate of Haversian and Endosteal Bone Formation Measured in Tetracycline Labelled Human Ribs, J Lab Clin Med67:633-639, 1966.
13.
Epker, B.N. , and Frost, H.M.: A Histological Study of Remodeling at the Periosteal, Haversian Canal, Cortical Endosteal, and Trabecular Endosteal Surfaces in Human Ribs, Anat Rec152:129-135, 1965.
14.
Takahashi, H., and Frost, H.M.: A Tetracycline-Based Evaluation of the Relative Prevalence and Incidence of Formation of Secondary Osteons in Human Cortical Bone, Canad J Physiol Pharmacol43 :783-791, 1965.
15.
Villanueva, A.R.; Klein, M.; and Frost, H.M.: Effect of Adrenalcorticoid Hormones on Human Lamellar Bone: Quantitative Histological Measurements of Resorption and Formation Indices, Henry Ford Hosp Med Bull12:63-73, 1964.
16.
Klein, M.; Villanueva, A.R.; and Frost, H.M.: A Quantitative Histological Study of Rib from 18 Patients Treated with Adrenal Cortical Steroids, Acta Orthop Scand35: 171-184, 1965.
17.
Landeros, 0. , and Frost, H.M.: Radial Rate of Osteon Closure, Measured by Mean of Tetracycline Labelling, Henry Ford Hosp Med Bull12:499-505, 1964.
18.
Jett, S.; Ramser, J.R.; Frost, H.M.; and Villanueva, A.R. : Bone Turnover and Osteogenesis Imperfecta , Arch Path81: 112-116, 1966.
19.
Van Der Sluys Veer, J.; Smeenk, D.; and Van Der Heul , R.O.J.: Tetracycline Labelling of Bone in Hyperparathyroidism, Bone and Tooth, New York : Macmillan Co., 1964, pp 85-91.
20.
Marshall, J.H. ; Jowsey, J.; and Rowland, R.E.: Microscopic Metabolism of Calcium in Bone: IV. Ca45 Deposition and Growth Rate in Canine Osteons, Radiat Res10 :243-257, 1959.
21.
Vanderhoeft, P.J.; Kelly, P.J.; and Peter-Son , L.F.A.: Determination of Growth Rates in Canine Bone by Means of Tetracycline-Labelled Patterns , Lab Invest11: 714-726, 1962.
22.
Marotti, G. : Quantitative Studies on Bone Reconstruction: I. The Reconstruction in Homotypic Shaft Bones, Acta Anat52: 291-333, 1963.
23.
Lee, W.R. : Appositional Bone Formation in Canine Bone: A Quantitative Microscopic Study Using Tetracycline Markers, J Anat98:665-677, 1964.
24.
Lee, W.R. ; Marshall, J.H.; and Sissons, H.A.: Calcium Accretion and Bone Formation in Dogs: An Experimental Comparison between the Results of Ca45 Kinetic Analysis and Tetracycline Labelling, J Bone Joint Surg47-B:157-180, 1965.
25.
Tapp, E.: Tetracycline Labelling Methods of Measuring the Growth of Bone in the Rat , J Bone Joint Surg48-B:517-525, 1966.
26.
Tapp, E.: The Effects of Hormones on Bone in Growing Rats, J Bone Joint Surg48-B:526-531, 1966.
27.
Adkins, K.F. : The Effect of Single Doses of X-Radiation on Mandibular Growth, Brit J Radiol39:602-606, 1966.
28.
Phillips, R.D. , and Kimeldorf, D.J.: Acute and Long-Term Effects of X-Irradiation on Skeletal Growth in the Rat, Amer J Physiol207:1447-1451, 1964.
29.
Phillips, R.D. , and Kimeldorf, D.J.: Long-Term Effects of Neutron Exposure on Bone Growth in the Rat, Radiat Res23: 491-499, 1964.
30.
Cohn, S.H.: Effects of Aging and X-Irradiation on the Kinetics of Skeletal Metabolism in the Rat, Radiat Res15:355-365, 1961. 31. Pappas, A.M., and Cohen, J.: The Abscopal Effect of X-Irradiation on Bone Growth in Rats, J Bone Joint Surg45-A:765-772, 1963. 32. Conard, R.A.: Indirect Effect of X-Radiation on Bone Growth in Rats, Ann NY Acad Sci114:335-338, 1964.
31.
Zuppinger, A., and Minder, W.: Calcium Uptake in Irradiated Bone , in Intern at Conf Peaceful Uses of Atomic Energy22 :247-279, 1958.
32.
Babicky, A. , and Kolar, J.: Generalized Skeletal Response to Local Radiation Retardation Induced by X-Irradiation, Radiat Res27:384-396, 1966.
33.
Phillips, R.D. , and Kimeldorf, D.J.: Age and Dose Dependence of Bone Growth Retardation Induced by X-Irradiation, Radiat Res27:384-396, 1966.
34.
Phillips, R.D. , and Kimeldorf, D.J.: Local and Systemic Effects of Ionizing Radiation on Bone Growth, Amer J Physiol210:1096-1100, 1966.
35.
Lougheed, M.N. , and Brown, B.St J.: Comparison of the Effect of Cobalt-60 and 250 kv Radiation on the Bones of the Rat, Radiology78:278-280, 1962.
36.
Blackburn, J., and Wells, A.B.: Radiation Damage to Growing Bone: The Effect of X-Ray Doses of 100 to 1,000 R on Mouse Tibia and Knee-Joint , Brit J Radiol36 :505-513, 1963.
37.
Frost, H.M. : Preparation of Thin Undecalcified Bone Sections by Rapid Manual Method, Stain Techn33:273-277, 1958. 40. Bures, M.F., and Wuehrmann , A.H.: Bone-Remodeling Dynamics following X-Radiation, J Dent Res46:171, 1967.