Three studies were conducted in the rat to determine relative amounts of radiophosphorus present in various hard tissues and body fluids when provided as various inorganic phosphates. Considerable variation was observed in metabolic activity of the phosphates, with NaH2PO4 having the greater activity.
Get full access to this article
View all access options for this article.
References
1.
Nizel, A.E., and Harris, R.S.: The Effect of Phosphates on Experimental Dental Caries: A Literature Review , J Dent Res43:1123-1136, 1964 .
2.
McDonald, J.L.; Stookey, G.K.; and Muhler, J.C.: Unpublished report.
3.
Chievitz, 0. , and Hevesy, G.: Radioactive Indicators in the Study of Phosphorus Metabolism in Rats, Nature (London)136: 754-755, 1935.
4.
Dols, M.J.L. , and Jansen, B.C.P.: Phosphorus Metabolism in Normal, Rachitic, and "Treated" Rats, Nature (London)139: 1068, 1937 .
5.
Manly, J.L., and Bale, W.F.: The Metabolism of Inorganic Phosphorus of Rat Bones and Teeth as Indicated by the Radioactive Isotope, J Biol Chem129:125-134, 1939.
6.
Manly, R.S.; Hodge, H.C.; and Manly, L.F.: The Relation of the Phosphorus Turnover of the Blood to the Mineral Metabolism of the Calcified Tissues as Shown by Radioactive Phophorus, J Biol Chem134:293-299, 1940.
7.
Manly, M.F.; Hodge, H.C.; and Van Voorhis, S.N. : Distribution of Ingested Phosphorus in Bone and Teeth of a Dog, Shown by Radioactive Isotope, Proc Soc Exp Biol Med45:70-72, 1940.
8.
Volker, J.F. , and Sognnaes, R.F.: A Study of the Phosphorus Metabolism in the Dental Tissues of a Cat by Use of Radioactive Phosphorus, J Dent Res19 (abstr): 292, 1940.
9.
Sognnaes, R.F. , and Volker, J.F.: Studies on the Distribution of Radioactive Phosphorus in the Tooth Enamel of Experimental Animals, Am J Physiol133:112-120, 1941.
10.
Wasserman, F.; Blayney, J.R.; Groetz-Inger , G.; and Dewitt, T.G.: Studies on the Different Pathways of Exchange of Minerals in Teeth with the Aid of Radioactive Phosphorus, J Dent Res20:389-398, 1941.
11.
Hevesy, G., and Armstrong, W.D.: Exchange of Radiophosphorus by Dental Enamel, J Dent Res19 (abstr): 318, 1940. 12. Sognnaes, R.F., and Shaw, J.H.: Salivary and Pulpal Contribution to the Radiophorus Uptake in Enamel and Dentin, JADA44:489-505, 1952.
12.
Yen, P.J.J. ; Bogoroch, R.; Sognnaes, R.F.; and Shaw, J.H.: Topographic Sampling Method for Quantitative Radiotracer Evaluation in Bones and Teeth, J Dent Res37: 458-466, 1958.
13.
Sognnaes, R.F. ; Shaw, J.H.; and Bogoroch , R.: Radiotracer Studies on Bone, Cementum, Dentin, and Enamel of Rhesus Monkeys, Am J Physiol180:408-420, 1955.
14.
Manly, M.L. , and Levy, S.R.: Absorption Studies on Enamel, Dentin and Bone, J Am Chem Soc61:2588-2590, 1939 .
15.
Armstrong, W.D.: In Vitro Experiments on Exchange of Phosphate by Enamel and Dentin, Proc Soc Exp Biol Med44:28-30, 1940.
16.
Hodge, H.C. ; Van Huysen, G.; Bonner, J.F.; and Van Voorhis , S.N.: Absorption of Phosphates at Forty Degrees by Enamel, Dentin, Bone, and Hydroxyapatite as Shown by the Radioactive Isotope, J Biol Chem138:451-457, 1941.
17.
Johansson, E.G.; Falkenheim, J.; and Hodge, H.C.: The Absorption of Phosphates by Enamel, Dentin, and Bone: I. Absorption Time Studied by Means of the Radioactive Isotope , J Biol Chem159: 129-134, 1945.
18.
Falkenheim, M.; Neuman, W.F.; and Hodge, H.C.: Phosphate Exchange as the Mechanism for Absorption of the Radioactive Isotope by the Calcified Tissues, J Biol Chem169:713-722, 1947.
19.
Ericsson, Y. : The Uptake of Radiocalcium and Phosphorus by Intact and Carious Enamel Surfaces, Acta Odont Scand11:167-178, 1953-1954.
20.
Stookey, G.K. , and Muhler, J.C.: The Anticariogenic Effect in the Rat of Cereals Fortified with a Soluble Phosphate, J Dent Res45:856-864, 1966.
21.
Stookey, G.K. ; Carroll, R.C.; and Muhler, J.C.: The Clinical Effectiveness of Phosphate-Enriched Breakfast Cereals on the Incidence of Dental Caries in Children, Results after Two Years, JADA74 :752-758, 1967.
22.
Nizel, A.E., and Harms, R.S.: Effects of Cations on the Cariostatic Activity of Orthophosphates, J Dent Res44:416-420, 1965.
23.
Buttner, W. , and Muhler, J.C.: A Method for the Determination of Enamel Solubility in Intact Rat Molars Using Highly Concentrated Fluoride Solutions , J Dent Res36:897-903, 1957.