Streptococcus isolated from human carious dentin can derive its carbon solely from a medium composed of a salt solution with added chondroitin sulfate or hyaluronic acid. The growth is inhibited by sodium fluoride. It is suggested that carious dentin results from streptococcal hydrolysis of dentin polysaccharides.
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References
1.
Volker, J.F. : What is the Scope of Our Knowledge of the Dental Caries Process? J Calif Dent Assoc26:10-15, 1950.
2.
Mitchell, D.F. : The Mechanism of Dental Caries, J Amer Dent Assoc52:14-18, 1956.
3.
Engel, M.B.: Glycogen and Carbohydrate -Protein Complex in Developing Teeth of the Rat , J Dent Res27:681-692, 1948.
4.
Fullmer, H.M. , and Alpher, N.: Histochemical Polysaccharide Reactions in Human Developing Teeth, Lab Invest7 :163-170, 1958.
5.
Quintarelli, G., and Dellovo, M.C.: Mucopolysaccharide Histochemistry of Rat Tooth Germs, Histochemie3:195-207, 1963.
6.
Matthiessen, M.E.: Histochemical Studies of the Prenatal Development of Human Deciduous Teeth, Acta Anat55:201-223, 1963.
7.
Leblond, C.P. ; Belanger, L.F.; and Greulich , R.C.: Formation of Bones and Teeth as Visualized by Radioautography, Ann NY Acad Sci60:630-659, 1955.
8.
Symons, N.B.B. : A Histochemical Study of the Intertubular and Peritubular Matrices in Normal Human Dentine, Arch Oral Biol5:241-249, 1961.
9.
Belanger, L.F. : Autoradiographic Visualization of the Entry and Transit of S in Cartilage, Bone and Dentine of Young Rats and the Effect of Hyaluronidase in Vitro, Canad J Biochem Physiol32 :161-169, 1954.
10.
Hess, W.C., and Lee, C.: The Isolation of Chondroitin Sulfuric Acid from Dentin, J Dent Res31:793-797, 1952.
11.
Symons, N.B.B. : A Histochemical Study of the Odontoblast Process , Arch Oral Biol7:455-462, 1962.
12.
Johansen, E. , and Parks, H.F.: Electron Microscopic Observations on Sound Human Dentin, Arch Oral Biol7:185-193, 1962.
13.
Engel, M.B. : A Mechanism for the Softening and Solution of the Dentin in Caries, J Dent Res27:716, (Abstract) 1948.
14.
Engel, M.B.: The Softening and Solution of Dentin in Caries, J Amer Dent Assoc40:284-294, 1950.
15.
Steinman, R.R. : Possible Role of Bacterial Hyaluronidase in Incipient Carious Lesions, J Dent Res39:150-152, 1960.
Prendergast, R.C.; Toto, P.D.; and Gar-Giulo , A.W.: Reactivity of Blood Group Substances of Neoplastic Oral Epithelium, J Dent Res47:306-310, 1968.
18.
Parikh, S.R.; Toto, P.D.; and Grisamore, T.L.: Streptococcal Hyaluronidase in Dentin Caries, J Dent Res44:996-1001, 1965. 20. Mahler, I.R., and Lisanti, V.F.: Hyaluronidase Producing Microorganisms from Human Saliva, Oral Surg5:1235-1240, 1952.
19.
Lorina, P.L. ; Lisanti, V.F.; and Chauncey , H.H.: The Production of Beta Glucuronidase and Hyaluronidase by Streptococcus mitis, Oral Surg7:998-1010, 1954.
20.
Orland, F.J. ; Blayney, J.R.; Harrison, R.W.; Reyniers, J.A.; Trexler, P.C.; Wagner, M.; Gordon, H.A.; and Luckey, T.D.: Use of the Germfree Animal Technic in the Study of Experimental Dental CariesI. Basic Observations on Rats Reared Free of All Microorganisms, J Dent Res33: 147-174, 1954.
Zinner, D.D. ; Jablon, J.M.; Aran, A.P.; and Saslaw, M.S.: Experimental Caries Induced in Animals by Streptococci of Human Origin, Proc Soc Exp Biol Med118: 766-770, 1965.
23.
Zinner, D.D. ; Aran, A.P.; Saslaw, M.S.; Jablon, J.M.; and Fitzgerald , R.J.: Induction of Dental Caries in Gnotobiotic Rats by Streptococci of Human Origin, Nature213:200-201, 1967.
24.
Mahler, I.R. , and Manly, R.S.: The pH Levels Attained by Compact Layers of Oral Microorganisms in Contact with Glucose Solutions, J Dent Res35:226-232, 1956.
25.
Lilienthal, B.: The Effect of Fluoride on Acid Formation by Salivary Sediment, J Dent Res35:197-204, 1956.
26.
Harper, H.A.: Review of Physiological Chemistry, ed 9, Los Altos, Calif. : Lange Medical Publishers, 1963 , p 13.
27.
Wright, D.E. , and Jenkins, G.N.: The Effect of Fluoride on the Acid Production of Saliva-Glucose Mixtures, Brit Dent J96:30-33, 1954.
