Parasympathetic stimulants were found to encourage the movement of fluid through the dentin from the pulp to the dentinoenamel junction. Regular treatment with a parasympathetic stimulant in rats that had all their major salivary glands removed significantly reduced the incidence of dental caries. Treatment with bradykinin in rats on a noncariogenic diet encouraged the movement of fluid into the tooth. When given regularly for 15 weeks, bradykinin caused significant dental caries.
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