Studies were conducted with children who ingested a supplemental fluoride-vitamin preparation, and the pattern of fluoride excretion during a three-year period was investigated. The rate of excretion was greater than the control level throughout a 24-hour period, although the greatest rate of excretion occurred within the first two hours.
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References
1.
Hennon, D.K. , and Muhler, J.C.: Clinical Use of Fluorides, J Indiana Dent Assoc41: 88-95, 1962.
2.
Muhler, J.C. ; Stookey, G.K.; Spear, L.B.; and BixLER , D.: Blood and Urinary Fluoride Studies Following the Ingestion of Single Dosages of Fluoride, J Oral Ther2: 241-260, 1966.
3.
Machle, W.; Scott, E.W.; and Largent, E.C.: The Absorption and Excretion of FluoridesI. The Normal Fluoride Balance, J Industr Hyg24:199-204, 1942.
4.
Mcclure, F.J. ; Mitchell, H.H.; Hamil-Ton, T.S.; and Kinser, C.A.: Balances of Fluorine Ingested From Various Sources in Food and Water by Five Young Men, Excretion of Fluorine Through the Skin, J Industr Hyg27:159-170, 1945.
5.
Mcclure, F.J.: "Non-Dental Physiological Effects of Trace Quantities of Fluoride," in F. R. Moulton (ed.), Dental Caries and Fluorine, Washington DC: American Association for the Advancement of Science, 1946, pp 74-92.
6.
ZiPKiN, I., and Leone, N.C.: Rate of Urinary Fluoride Output in Normal Adults, Amer J Public Health47:848-851, 1957.
7.
Hennon, D.K. ; Stookey, G.K.; and Muhler, J.C.: The Clinical Anticariogenic Effectiveness of Supplementary Fluoride-Vitamin Preparations. Results at the End of Three Years, J Dent Child33:3-12, 1966.
8.
Hennon, D.K. ; Stookey, G.K.; and Muhler, J.C.: Fluoride Retention in Rats Receiving Various Vitamin-Sodium Fluoride Preparations, J Pediat64:272-277, 1964.
9.
Harkins, R.W. ; Longenecker, J.B.; and Sarett, H.P.: The Effect of NaF on the Growth of Rats with Varying Vitamin and Calcium Intakes, J Nutr81:81-86, 1963.
10.
Weddle, D.A. , and Muhler, J.C.: The Effects of Inorganic Salts on Fluorine Storage in the Rat, J Nutr54:437-444, 1954.
11.
Schweinsberger, R., and Muhler, J.C.: Urinary Fluoride Levels in Children Following the Clinical Use of a Stannous Fluoride-Containing Dentifrice, J Dent Res35:760-762, 1956.
12.
Schweinsberger, R., and Muhler, J.C.: Urinary Excretion of Fluoride by Children Ages Two Through Five Years Using a Stannous Fluoride-Containing Dentifrice in a Natural Fluoride Area and a Non-Fluoride Area, J Pediat51:634-638, 1957.
13.
Weddle, D.A. , and Maurer, R.L.: Method of Preparation of Fluorine-Low Calcium Oxide, Anal Chem26:584-585, 1954.
14.
Zipkin, I.; Likins, R.C.; Mcclure, F.J.; and Steere, A.C.: Urinary Fluoride Levels Associated with Use of Fluoridated Waters, Public Health Rep71:767-772, 1956.
15.
Largent, E.J.: "Metabolism of Inorganic Fluoride," in J. H. Shaw (ed.), Fluoridation as a Public Health Measure, Washington, DC: American Association for the Advancement of Science, 1954, pp 49-78.
16.
Glock, G.E.; Lowater, F.; and Murray, M.M.: The Retention and Elimination of Fluorine in Bones. J Biochem35:1235-1239, 1941.
17.
Blakemore, F. ; Bosworth, T.J. ; and Green, H.H.: Industrial Fluorosis of Farm Animals in England, Attributable to the Manufacture of Bricks, Calcining of Iron-stone, and to Enameling Processes, J Comp Path58:267-291, 1948.
18.
Savchuck, W.B. , and Armstrong, W.D.: Metabolic Turnover of Fluoride by the Skeleton of the Rat, J Biol Chem193 :575-585, 1951.
19.
Miller, R.F. , and Phillips, P.H.: The Metabolism of Fluorine in the Bones of the Fluoride-Poisoned Rat, J Nutr51 :273-278, 1953.
20.
Weddle, D.A. , and Muhler, J.C.: Metabolism of Small Concentrations of Fluorine in the Albino Rat, J Dent Res34 :900-909, 1955.
21.
Likins, R.C. ; McClure, F.J.; and Steere, A.C.: Urinary Excretion of Fluoride Following Defluoridation of a Water Supply, Public Health Rep71:217-220, 1956.
22.
Brun, G.C.; BucHwALD, H.; and Roholm, K.: The Excretion of Fluorine in the Urine in Chronic Fluorine Poisoning of Cryolite Workers, Acta Med Scand106:261-273. 1941.
23.
Machle, W., and Largent, E.J.: The Absorption and Excretion of Fluoride: II. The Metabolism at High Levels of Intake, J Industr Hyg25:112-123, 1943.
24.
Largent, E.J. , and Heyroth, F.F.: The Absorption and Excretion of Fluorides: III. Further Observations on Metabolism of Fluorides at High Levels of Intake , J Industr Hyg31:134-138, 1949.
25.
Largent, E.J. : Rates of Elimination of Fluoride Stored in the Tissues of Man, Arch Ind Hyg6:37-42, 1952.
26.
Stookey, G.K. ; Wagner, M.J.; and Muhler, J.C.: Effect of Previous Exposure to Fluorine and Age on Fluoride Metabolism, abstracted in J Dent Res37:72, 1958.
