Rats of both Hunt-Hoppert lines, originally designated as caries-susceptible (Ca-S) and caries-resistant (Ca-R) lines, were highly susceptible to caries when subjected to a combination of diet and microflora that provided a challenge to the resistance of all surfaces of the teeth. Strain differences were indicated by the predominance of sulcal lesions in the Ca-S line and smooth-surface lesions in the Ca-R line.
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