A Mikulicz-like disease of the lacrimal glands occurred after six weekly subcutaneous injections of 10 mg of 5-hydroxytryptamine. The lacrimal glands of all experimental rats developed a dense lymphocytic infiltration that caused destruction of acinar cells.
Get full access to this article
View all access options for this article.
References
1.
Bhaskar, S.N. , and Bernier, J.L.: Mikulicz's Disease. Clinical Features, Histology and Histogenesis ; Report of Seventy-three Cases, Oral Surg13:1387-1399, 1960 .
2.
Bernier, J.L. , and Bhaskar, S.N.: Lymphoepithelial Lesions of Salivary Glands; Histogenesis and Classification Based on 186 Cases, Cancer11:1156-1179, 1958.
3.
Godwin, J.T. : Benign Lymphoepithelial Lesion of Parotid Gland (Adenolymphoma, Chronic Inflammation, Lymphoepithelioma, Lymphocytic Tumor, Mikulicz's Disease); Report of II Cases, Cancer5:1089-1103, 1952.
4.
Garattini, S., and Valzelli, L.: Serotonin, New York: American Elsevier Publishing Co., 1965.
5.
Selye, H., and Winandy, G.: Serotonin-Induced Thrombohemorrhagic Lesions in the Salivary and Lacrimal Glands, Vasc Dis3:116-121, 1966.
6.
Feldberg, W., and Smith, A.N.: Release of Histamine by Tryptamine and 5-hydroxytryptamine, Brit J Pharmacol8:406-411, 1953.
7.
Lewis, G.P. (ed.): 5-Hydroxytryptamine; Proceedings of a Symposium Held in London on April 1 and 2, 1957, London: Pergamon Press, 1958.
