SYNOPSIS IN INTERLINGUA LE EFFECTOS DE CORTISONA E THALIDOMIDA SUPER LE MORPHOGENESE DEL PALATO SECUNDARI IN MUSES A/HEJ.—Un studio del palatogenese normal durante le periodo inter die 11 1/2 e 16 1/2 post le conception ha monstrate que le clausura palatal occurre approximativemente al die 15. Le administration intraperitonee de thalidomida in doses de 10 e de 15 mg. resultava in nulle malformation palatal quando illo esseva effectuate 11 1/2 dies post le conception. Acetato de cortisona in doses de 5 e 10 mg. causava 35, respectivemente 83 pro cento de palatos fisse.
Get full access to this article
View all access options for this article.
References
1.
Trasler, D.G. , Clark, K.H., and Fraser, F.C.No Cleft Palates in Offspring of Pregnant Mice Given Cortisone after Fetal Palate Closure, J. Hered. , 47 :99-100, 1956.
2.
Kalter, H.Factors Influencing Frequency of Cortisone-Induced Cleft Palate in Mice, J. exp. Biol., 134: 449-67, 1957.
3.
Isaacson, R.J. , and Chaudhry, A.P.Cleft Palate Induction in Strain A Mice with Cortisone, Anat. Rec., 142:479-83, 1962.
4.
Fraser, F.C. , and Fainstat, T.D.Production of Congenital Defects in Offspring of Pregnant Mice Treated with Cortisone, Pediatrics, 8:527-33, 1951.
5.
Fraser, F.C.Kalter, H., Walker, B.E., and Fainstat , T.D.Experimental Production of Cleft Palate with Cortisone and Other Hormones, J. cell. comp. Physiol., 43:1:237-59, 1954.
6.
Fraser, F.C.Experimental Teratogenesis, Wld-Wide Abstr. gen. Med., 7:8-17, 1964.
