Dose-Response of Submandibular Glands to Carcinogen Pellets in Rats and Hamsters

Abstract

LE RELATION INTER DOSE DE GRANOS DE CARCINOGENOS E LE RESPONSA DEL GLANDULAS SUBMANDIBULAR IN RATTOS E HAMSTERS.-Pro studiar le effecto carcingenic de 5, 10, e 20 pro cento 7:12-dimethylbenz-γ-anthraceno mixte con glycerol polyethylenic, granos continente le mixtura experimental esseva implantate in le glandulas submandibular de rattos e hamsters durante un periodo de 24 septimanas. Un augmento in le dose del carcinogeno resultava in un augmento correspondente in le inducite tumores maligne in ambe species. Tamen, plus carcinomas de cellulas squamose esseva notate in le rattos e plus sarcomas in le hamsters. Iste statisticamente significative differentia in le typo de tumor inducite es attribuite a specificitate de tissu o de specie.

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