Effect of Parathyroid Extract on the Development of Wound Rupture Strength

Abstract

SYNOPSIS IN INTERLINGUA

EFFECTO DE EXTRACTO PARATHYROIDIC SUPER LE DISVELOPPAMENTO DEL FORTIA RUPTURAL IN VULNERES. -Recente studios ha demonstrate que extracto parathyroidic es capace a stimular un factor collagenolytic in osso. Tamen, le responsa de altere tissus conjunctive a extracto parathyroidic ha non essite determinate con respecto a un tal factor. Le presente studio esseva un essayo de demonstrar le effecto de extracto parathyroidic super primari vulneres de pelle in stato de guarition in juvene rattos. Vulnerate animales recipeva un injection de 200 unitates de extracto parathyroidic omne die durante tres dies ante lor sacrificio. Le animales esseva sacrificate 6, 9, e 12 dies post le vulneration. Un analyse statistic del fortia ruptural del vulneres revelava un significative augmento del fortias in vulneres post 9 dies. Le constatationes esseva interpretate como non supportante le hypothese que extracto parathyroidic stimula un factor collagenolytic in le tissu conjunctive de un vulnere in guarition.

Get full access to this article

View all access options for this article.

References

Belanger, L.F. , and Migicovsky, B.B. Histochemical Evidence of Proteolysis of Bone. The Influence of Parathormone, J. Histochem. Cytochem. , 11 :734-37,1963.

Walker, D.G. , Lapiere, C.M. , and Gross, J.A. Collagenolytic Factor in Rat Bone Promoted by PTE, Biochem. Biophys. Res. Comm., 15:397-402, 1964.

Woods, J.F. , and Nichols, G. Collagenolytic Activity in Mammalian Bone, Science , 142:386-87, 1963.

Bates, W.K. , Awapora, J. , and Talmage, R.V. Parathyroid Influence on Removal of Hydroxyproline by Peritoneal Lavage in the Rat, Proc. Soc. exp. Biol. Med., 115:650, 1964.

Bates, W.K. , McGowen, J. , and Talmage, R.V. Influence of Parathyroid on Plasma Hydroxyproline Level, Endocrinology, 71:185-95, 1962.

Benoit, F.L. , Theil, G.B. , and Watten, R.H. Hydroxyproline Excretion in Endocrine Disease , Metabolism, 12:1072-82, 1963.

Flanagan, B. , and Nichols, G. , JR. Parathyroid Inhibition of Bone Collagen Synthesis, Endocrinology, 74:180-86, 1964.

Keiser, H.R. , Gill, J.R. , Sjoudsma , A. , and Barther, F.C. Relation Between Urinary Hydroxyproline and Parathyroid Function, J. I. Invest. , 43:1073-82, 1964.

Dunphy, J.E. , and Udupa, K.M.

Chemical and Histochemical Sequences in the Normal Healing of Wounds, New England

J. Med., 253:847-51, 1955.

10.

Edwards, L.C. , Pernokas, L.M. , and Dunphy, J.E. The Use of a Plastic Sponge to Sample Regenerating Tissue in Healing Wounds, Surg. , Gyn., & Obst., 105:303-09, 1957.

11.

Grillo, H.C. , Watts, G.T. , and Gross, J. Studies in Wound Healing. 1. Contraction and the Wound Contents, Ann. Surg. , 148:145-51, 1958

12.

Jackson, D.S. , Flickinger, D.B. , and Dunphy, J.E. Biochemical Studies of Connective Tissue Repair. Ann. N.Y. Acad. Sci. , 86:943-47, 1960.

13.

Campani, M. , Cortinovis, R. , and Zonto, A. Studies on Wound Healing; Metabolism of S35 in Repair Tissue of Skin Wounds During Various Phases of Healing, Experientia, 16:423-24, 1960.

14.

Bronner, F. Effects of Parathyroid Extract on Metabolism of Sulfate in Immature Rats, Amer. J. Physiol., 198:605-08, 1960.

15.

Little, J.W. , Bickley, H.C., ToPAZIAN, R. G. , and Mateer, R.S. Analysis of the Mechanical Properties of the Healing Skin Wound, J. Biorhealogy , 1966. Submitted for publication.

16.

Cochran, W.G. , and Cox, G.M. Experimental Designs, ed. 2. New York, John Wiley , 1960.

17.

Banga, I. , Balo, J. , and Szabo, D. The Enzymatic Degradation of Collagen Fiber. In: Collagen , N. Ramanathan , editor. New York, Interscience Publishers, 1962.

18.

Gross, J. Studies on the Biology of Connective Tissues: Remodeling of Collagen in Metamorphosis , Medicine, 43:291-303, 1964.

19.

Bickley, H.C. , Little, J.W. , and Blevins, T.J. The Effects of Short-Term Lathyrogen Treatment on Rupture Strength of Healing Wounds, J. dent. Res., 45:1966. In press.