The Effects of Phosphates on Experimental Dental Caries: A Literature Review

Hoppert, C.A. , Webber, P.A. , and Canniff, T.L. The Production of Dental Caries in Rats Fed an Adequate Diet, Science, 74:77, 1931.

Klein, H. and Mccollum, E.V. A Preliminary Note on the Significance of the Phosphorus Intake in the Diet and Blood Phosphorus Concentration in the Experimental Production of Caries Immunity and Caries Susceptibility in the Rat, Science, 84:662, 1931.

-. The Significance of Food-Particle Size in the Etiology in Microscopic Dental Decay in Rats, J. dent. Res., 13:69, 1933.

Klein, H. , and Shelling, D.H. The Relation of Diet to the Toxicity of Viosterol as a Determining Factor in the Production of Experimental Caries in Rats, J. dent. Res., 11 :458, 1931.

Blackberg, S.N. , and Berke, J.D. Dental Caries Experimentally Produced in the Rat, J. dent. Res., 12:609, 1932.

Agnew, M.C. , Agnew, R.S. , and Tisdall, F.F. The Production and Prevention of Dental Caries, J. Amer. dent. Ass., 20:193, 1933.

Rosebury, T. , and Karshan, M. Susceptibility to Dental Caries in the Rat. V. Influence of Calcium, Phosphorus, Vitamin D and Corn Oil, Arch. Path., 20:697, 1935.

Shelling, D.H. , and Asher, D.E. Calcium and Phosphorus Studies. VII. Some Observations on the Incidence of Caries-like Lesions in the Rat, J. dent. Res., 13:363, 1933.

Sobel, A.E. , Rockenmacher, E.M. , Weinstein, J. , and Kramer, B. The Influence of Dietary Calcium and Phosphorus on Bone Composition, Abst. Div. Biol. Chem. Buffalo, N.Y.: Amer. Chem. Soc., 1942.

Sobel, A.E. Composition of Teeth in Relation to Caries Susceptibility. Trans. Josiah Macy, Jr. Conf. Metabolic Interrelations , 41:261, 1952.

Stralfors, A. En Method for Kariesprofylax (A Method for Caries Prevention), Sverig. Tandläk.-Förb. Tidn., 46:413, 1954.

-. Karieshamning Genom Fosfater, Svensk tandläk.-T. , 49:108, 1956.

Nizel, A.E. , and Harris, R.S. The Cariostatic Effects of Ashed Foodstuffs Fed in the Diets of Hamsters, J. dent. Res., 32:672, 1953 (abstr.).

---. Effects of Ashed Foodstuffs on Dental Decay in Hamsters , J. dent. Res., 34:513, 1955.

Harris, R.S. , Nizel, A.E. , and Gardner, D.S. Effect of Food Ash and Trace Minerals upon Dental Caries in Hamsters, p. 195, 4th Int. Cong. Nutr, 1957.

Harris, R.S. , and Nizel, A.E. Effects of Food Ash, Phosphate and Trace Minerals upon Hamster Caries, J. dent. Res., 38:1142, 1959.

Wynn, W. , Haldi, J. , Bentley, K.D. , and Law, M.L. Dental Caries in the Albino Rat in Relation to the Chemical Composition of the Teeth and to the Diet. IV. Variations in the Ca/P Ratio of the Diet Induced by Changing the Calcium Content, J. Nutr., 67:645, 1959.

McClure, F.J. Wheat Cereal Diets, Rat Caries, Lysine and Minerals , J. Nutr., 65:619, 1958.

Sognnaes, R.F. , and Shaw, J.H. Experimental Rat Caries. IV. Effect of a Natural Salt Mixture on the Caries Conduciveness of an Otherwise Purified Diet, J. Nutr., 53:195, 1954.

Constant, M.A. , Sievert, H.W. , Phillips , P.H. , and Elvehjem , C.A. Dental Caries in the Cotton Rat. XIV. Further Studies of Caries Production by Natural Diets with Especially Reference to the Role of Minerals, Fat, and the Stage of Refinement of Cereals, J. Nutr., 53:17, 1954.

McClure, F.J. , Folk, J.E. , and Rust, J.D. Smooth Surface Caries in White Rats. Effects of Fluoride, Iodoacetate, Penicillin, Crisco, Butterfat and a Salt Mixture , J. Amer. dent. Ass., 53:1, 1956.

Losee, F.L. , Levy, G.A. , and Zagrosky , J.P. Influence of Varying Mineral Intake on Weight and Caries in the NMRI Strain of Osborne Mendel Rat, Naval Med. Res. Inst. Rep., 15:503, 1957.

Mitchell, D.F. , Helman, E.Z. , and Chernausek , D.S. Ammoniated Dentifrices and Hamster Caries : Further Studies on the Effects of Ingestion, Science , 116:537, 1952.

Van Reen, R. , König, K.G. , Ostrom, C.A. , and McClure, F.J. Evaluation of Dental Caries in the Rat: A Comparison of Grinding and Slicing Techniques in Two Strains of Rats Fed a Purified Diet of High Cariogenic Capacity with Orthophosphate Supplements , Arch. oral Biol., 7:481, 1962.

Stralfors, A. Inhibition of Dental Caries in Hamsters. I. The Effect of Sodium Phosphate, Odont. Revy, 12:111, 1961.

Barnard P. , and Johansen, F. Effect of 2 Per Cent CaHPO4 Dietary Supplement on Experimental Dental Caries in the Rat, J. dent. Res., 37:34, 1958 (abstr.).

Nizel, A.E. , Harris, R.S. , and Parker, J.M. Inhibitory Effect of Disodium Phosphate on Dental Caries in the Rat , J. dent. Res., 40:660, 1961 (abstr.).

Wynn, W. , Haldi, J. , Bentley, K.D. , and Law, M.L. Dental Caries in the Albino Rat in Relation to the Chemical Composition of the Teeth and of the Diet. II. Variation in the Ca/P Ratio of the Diet Induced by Changing the Phosphorus Content, J. Nutr., 58:325, 1956.

Sobel, A.E. , Shaw, J.H. , Hanok, A. , and Nobel,S. Calcification. XXVI. Caries Susceptibility in Relation to Composition of Teeth and Diet, J. dent. Res., 39:462, 1960.

Strålfors, A. Inhibition of Dental Caries in Hamsters. II. The Effect of Tribasic Calcium Phosphate, Odont. Revy, 12:24, 1961.

-. Inhibition of Dental Caries in Hamsters. III. The Effect of Tribasic Calcium Phosphate. Weekly Change of Diet. Calcium Phosphate Given in Pills, ibid., pp. 136.

-. Inhibition of Dental Caries in Hamsters. IV. The Effect of Tribasic Calcium Phosphate in Bread. The Effect of Calcium Phosphate in Bread. The Effect of Calcium in Drinking Water, ibid., pp. 225.

-. Inhibition of Dental Caries in Hamsters. V. The Effect of Dibasic and Monobasic Calcium Phosphate, ibid., pp. 3361.

McClure, F.J. , and Muller, A. , JR. Caries Inhibiting Effect of Dibasic Sodium Phosphate and Dibasic Calcium Phosphate Added to Wheat Four and Bread Diets , J. Amer. dent. Ass., 58:36,1959.

Van Reen, R. , and Glassford, K.F. The Caries Inhibiting Effects of Na2HPO4 and CaHP04, J. dent Res., 38:633, 1959.

Nizel, A.E. , Baker, N.J. , and Harris, R.S. The Effect of Phosphate Structure upon Dental Caries Development in Rats, Int. Ass. dent. Res. 1962 (abstr.).

König, K.G. , Marthaler, T.M. , and Mühlemann , H.R. Effects of Some Phosphates in a Short-Period Rat Caries Experiment, Arch. oral Biol. , 3:258, 1961.

Limbasuta, S. , Singh, B. , and Johansen, E. The Effect of Sodium Phytate and Sodium Acid Pyrophosphate on Rat Caries, J. dent. Res., 40:658, 1961.

Van Reen, R. , and Ostrom, C.A. Effect of Dietary Phosphate Supplements on Dental Caries, J. dent. Res., 41:875, 1962.

McClure, F.J. The Cariostatic Effect in White Rats of Phosphorus and Calcium Supplements Added to the Flour of Bread Formulas and to Bread Diets, J. Nutr., 72:131, 1960.

McClure, F.J. , and McCann, H.G. Dental Caries and Composition of Bones and Teeth of White Rats: Effect of Dietary Mineral Supplements, Arch. oral Biol., 2:151, 1960.

McClure, F.J. , and Muller, A. , JR. Further Observations on the Cariostatic Effect of Phosphates, J. dent. Res., 38:776, 1959.

Nizel, A.E. , Keating, N. , Sundstrom , C. , and Harris, R.S. Effect of Phosphate Supplement to Diet on Development of Hamster Caries, J. dent. Res., 37:35, 1958 (abstr.).

Nizel, A.E. , and Harris, R.S. Effect of Different Levels of Metaphosphoric Acid on Hamster Caries, J. dent. Res., 38:686, 1959 (abstr.).

---. Effect of Metaphosphoric Acid in the Diet of Weanling Hamsters upon Dental Caries Development, J. Amer. dent. Ass. , 60:193, 1960.

Sobel, A.E. , and Hanok, A. Calcification. XVI. Composition of Bones and Teeth in Relation to Blood and Diet in the Cotton Rat, J. dent. Res., 37:631, 1958.

Wynn, W. , Haldi, J. , Bentley, K.D. , and Law, M.F. Dental Caries in the Albino Rat in Relation to the Chemical Composition of the Teeth and of the Diet. III. Composition of Incisor Teeth of Animals Fed Diets with Different Ca/P Ratios, J. Nutr., 63:57, 1957.

Barnard, P. , and Johansen, E. Effect of CaHPO4 and NaF Dietary Supplements on Experimental Caries, J. dent. Res., 37:82, 1958 (abstr.).

Mühlemann, H.R. , König, K.G. , and Marthaler , T.M. The Cariostatic Effect of Sodium Fluoride when Combined with Phosphates in Animal Experimentation , Helv. odont. Acta, 5:4, 1961.

Van Reen, R. , Ostrom, C.A. , and Berzinskas , U.J. , The Cariostatic Effect of Dietary Phosphate in the Rat in the Presence or Absence of Fluoride in the Drinking Water, Arch. oral Biol., 7:587, 1962.

Mühlemann, H.R. Phosphor und Cariesprophylaxe, Schweiz. med. Wschr., 91:221, 1961.

Harris, R.S. , Baker, N.J. , and Nizel, A.E. Cariostatic Effectiveness of Fat-Embedded Monopotassium Phosphate in the Diets of Rats , Int. Ass. dent. Res., p. 40, 1962 (abstr.).