Application of the Method of Steepest Ascent to the Response Surface of the Nitrate-Nitrite Reductase Activity in Salivary Sediment

Friedman, M. , and Savage, L.J. Planning Experiments Seeking Maxima, in C. Eisenhart , M. W. Hastay , and W. A. Wallis , Selected Techniques of Statistical Analysis, p. 363. New York: McGraw-Hill Book Co., Inc., 1947.

Fisher, R.A. The Design of Experiments, p. 91. Edinburgh: Oliver & Boyd, 1949 .

Yates, F. The Design and Analysis of Factorial Experiments. ( Imperial Bureau of Soil Sciences, Communication No. 35.) 1937.

Box, G.E.P. , and Wilson, K.B. On the Experimental Attainment of Optimum Conditions, J. Roy. Statist. Soc., Ser. B, 13:1, 1951.

Box, G.E.P. , and Hunter, J.S. A Confidence Region for the Solution of a Set of Simultaneous Equations with an Application to Experimental Design , Biometrika, 41:190, 1954.

Box, G.E.P. , and Youle, P.V. The Exploration and Exploitation of Response Surfaces: An Example of the Link between the Fitted Surface and the Basic Mechanism of the System, Biometrics, 11:287,1955.

Box, G.E.P. , and Hunter, J.S. Multifactor Designs , Ann. Math. Statist., 28:195, 1957.

Hader, R.J. , Howard, M.E. , Mason, D.D. , and Moore, D.P. An Investigation of Some of the Relationships between Copper, Iron, and Molybdenum in the Growth and Nutrition of Lettuce. I. Experimental Design and Statistical Methods for Characterizing the Response Surface, Proc. Soil Sci. Soc. Amer., 21:59, 1957.

Box, G.E.P. Multifactor Designs of First Order, Biometrika, 39:49, 1952.

Gardiner, D.A. , Grandage, A.H.E. , and Hader, R.J. Some Third Order Rotatable Designs , Ann. Math. Statist., 30:1082, 1959.

Box, G.E.P. , and Draper, N.L. A Basis for the Selection of a Response Surface Design, J. Am. Statist. Assoc., 54:622, 1959.

Box, G.E.P. , and Behnken, D.W. Derivation of Second Order Rotatable Designs from Those of First Order. Princeton: Statistical Techniques Research Group Technical Rept. No. 17, 1959.

Bose, R.C. , and Draper, N. Second Order Rotatable Designs, Ann. Math. Statist. , 30:1097, 1959.

Draper, N. A Third Order Rotatable Design in Four Dimensions. ( Institute of Statistics Mimeo Series, No. 198.) 1959.

Nielsen, K.L. Methods in Numerical Analysis, p. 260. New York: Macmillan Co., 1957.

Kaplan, W. Advanced Calculus, p. 79. Reading, Mass.: Addison-Wesley Press, 1957.

Ibid., p. 120.

Goaz, P.W. , and Biswell, H.A. Nitrate Reduction in Whole Saliva, J. D. Res., 40:355, 1961.

Snedecor, G.W. Statistical Methods , p. 394. Ames, Iowa: Iowa State College Press, 1956.

Ibid., p. 244.

Graybill, F.A. An Introduction to Linear Statistical Models , p. 149. New York: McGraw-Hill Book Co., Inc., 1961.