The oral–systemic relationship has long been a focus of vigorous debate. Spanning experimental studies that elucidate underlying mechanisms, critical reviews and advances in data architecture, and clinical and population-based investigations, this editorial highlights the compelling findings presented in this special issue.
AidaJKiuchiSShiraiKPeresMMatsuyamaY.2026. Oral health and dementia: causal inference and theoretical mechanisms. J Dent Res. 105(1):[Insert page numbers].
2.
BashirNWoolfBBurgessSBernabeE.2026. Periodontitis and systemic disease: the impact of covariate selection. J Dent Res. 105(1):[Insert page numbers].
3.
BayB, et al. 2026. Periodontal health and outcome of atherosclerotic disease in the Hamburg City Health Study. J Dent Res. 105(1):[Insert page numbers].
4.
CheeHK, et al. 2026. Long-term effect of periodontal therapy on HbA1c changes in type 2 diabetes. J Dent Res. 105(1):[Insert page numbers].
5.
ColpaniJT, et al. 2026. Mandibular advancement device versus CPAP in severe obstructive sleep apnea. J Dent Res. 105(1):[Insert page numbers].
6.
CoxKD, et al. 2026. Exploring the interplay of oral and systemic pathology in Sjögren’s Disease. J Dent Res. 105(1):[Insert page numbers].
7.
DödingA, et al. 2026. Fighting age-associated bone loss in periodontitis with dietary interventions. J Dent Res. 105(1):[Insert page numbers].
8.
EsemezieAOLizotteDJTsakosGGomaaNA. 2026. Social adversity is causally linked to multimorbidity including oral conditions. J Dent Res. 105(1):[Insert page numbers].
9.
GravesDTLevineMAAldosarySDemmerRT. 2026. Understanding the periodontitis–diabetes linkage: mechanisms and evidence. J Dent Res. 105(1):[Insert page numbers].
10.
MartinK, et al. 2026. Periodontitis leads to systemic bone loss through neutrophil reprogramming. J Dent Res. 105(1):[Insert page numbers].
11.
MohammadiM, et al. 2026. Tooth loss in individuals with dementia: a Swedish register-based cohort study. J Dent Res. 105(1):[Insert page numbers].
12.
NieF, et al. 2026. Periodontitis promotes OSCC and prostate cancer progression and immunosuppression by skewing myeloid differentiation of HSPCs. J Dent Res. 105(1):[Insert page numbers].
13.
NguyenKT, et al. 2026. Extracellular particles to track cancer biomarkers from tissue to biofluids. J Dent Res. 105(1):[Insert page numbers].
14.
PatelJSDinhE.2026. LinkMD: linking medical and dental records with 4 linking algorithms. J Dent Res. 105(1):[Insert page numbers].
15.
TayJ, et al. 2026. Perceived masticatory function and mortality: a causal study. J Dent Res. 105(1):[Insert page numbers].
16.
WangKMatsuyamaYKiuchiSKusamaTAidaJ.2026. Oral frailty as a predictor for weight loss in older Japanese: a cohort study. J Dent Res. 105(1):[Insert page numbers].
