The oral cavity is usually the first part of a consumer’s body exposed to the constituents of tobacco products or their emissions. Consequently, the oral cavity is a frequent site for carcinogenic, microbial, immunologic, and clinical effects of tobacco use. This article summarizes 5 presentations on various aspects of oral health affected by combusted or noncombusted tobacco products from a recent conference, “Oral Health Effects of Tobacco Products: Science and Regulatory Policy,” sponsored by the American Association for Dental Research and the Food and Drug Administration.
Aguilar-ZinserVIrigoyenMERiveraGMaupomeGSanchez-PerezLVelazquezC. 2008. Cigarette smoking and dental caries among professional truck drivers in Mexico. Caries Res. 42(4):255–262.
2.
AllamEZhangWZhengCGregoryRLWindsorLJ. 2011. Smoking and oral health. In: BernhardD, editor. Cigarette smoke toxicity: linking individual chemicals to human diseases. Weinheim (Germany): Wiley-VCH Verlag GmbH & Co. KGaA.
3.
AvsarADarkaOTopalogluBBekY. 2008. Association of passive smoking with caries and related salivary biomarkers in young children. Arch Oral Biol. 53(10):969–974.
4.
BalboSJames-YiSJohnsonCSO’SullivanMGStepanovIWangMBandyopadhyayDKassieFCarmellaSUpadhyayaPet al. 2013. (S)-N′-Nitrosonornicotine, a constituent of smokeless tobacco, is a powerful oral cavity carcinogen in rats. Carcinogenesis. 34(9):2178–2183.
5.
BeharRZDavisBWangYBahlVLinSTalbotP. 2014. Identification of toxicants in cinnamon-flavored electronic cigarette refill fluids. Toxicol In Vitro. 28(2):198–208.
6.
BeharRZLuoWLinSCWangYValleJPankowJFTalbotP. 2016. Distribution, quantification and toxicity of cinnamaldehyde in electronic cigarette refill fluids and aerosols. Tob Control. 25Suppl 2:ii94–ii102.
7.
BelstrømDHolmstrupPNielsenCHKirkbyNTwetmanSHeitmannBLKlepac-CerajVPasterBJFiehnNE. 2014. Bacterial profiles of saliva in relation to diet, lifestyle factors, and socioeconomic status. J Oral Microbiol. 6. doi:10.3402/jom.v6.23609.
8.
BowlesWHWilkinsonMRWagnerMJWoodyRD. 1995. Abrasive particles in tobacco products: a possible factor in dental attrition. J Am Dent Assoc. 126(3):327–331.
9.
CampusGCagettiMGSennaABlasiGMascoloADemarchiPStrohmengerL. 2011. Does smoking increase risk for caries? A cross-sectional study in an Italian military academy. Caries Res. 45(1):40–46.
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ClappPWLavrichKSvan HeusdenCLazarowskiERCarsonJLJaspersI. 2019. Cinnamaldehyde in flavored e-cigarette liquids temporarily suppresses bronchial epithelial cell ciliary motility by dysregulation of mitochondrial function. Am J Physiol Lung Cell Mol Physiol. 316(3):L470–L486.
CoreyCGAmbroseBKApelbergBJKingBA. 2015. Flavored tobacco product use among middle and high school students—United States, 2014. MMWR Morb Mortal Wkly Rep. 64(38):1066–1070.
13.
CullenKAAmbroseBKGentzkeASApelbergBJJamalAKingBA. 2018. Use of electronic cigarettes and any tobacco product among middle and high school students—United States, 2011–2018. MMWR Morb Mortal Wkly Rep. 67(45):1276–1277.
14.
DahlBLStolenSOOiloG. 1989. Abrasives in snuff?Acta Odontol Scand. 47(4):239–243.
15.
DelnevoCDWackowskiOAGiovencoDPManderskiMTHrywnaMLingPM. 2014. Examining market trends in the United States smokeless tobacco use: 2005–2011. Tob Control. 23(2):107–112.
16.
DjordjevicMVFanJBushLPBrunnemannKDHoffmannD. 1993. Effects of storage conditions on levels of tobacco-specific N-nitrosamines and N-nitrosamino acids in US moist snuff. J Agric Food Chem. 41(10):1790–1794.
17.
EdmanKOhrnKNordstromBHolmlundA. 2016. Prevalence of dental caries and influencing factors, time trends over a 30-year period in an adult population: epidemiological studies between 1983 and 2013 in the county of Dalarna, Sweden. Acta Odontol Scand. 74(5):385–392.
18.
EdwardsSHRossiterLMTaylorKMHolmanMRZhangLDingYSWatsonCH. 2017. Tobacco-specific nitrosamines in the tobacco and mainstream smoke of US commercial cigarettes. Chem Res Toxicol. 30(2):540–551.
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EkfeldtA. 1989. Incisal and occlusal tooth wear and wear of some prosthodontic materials: an epidemiological and clinical study. Swed Dent J Suppl. 65:1–62.
20.
El-BayoumyKChenKMZhangSMSunYWAminSStonerGGuttenplanJB. 2017. Carcinogenesis of the oral cavity: environmental causes and potential prevention by black raspberry. Chem Res Toxicol. 30(1):126–144.
21.
ErythropelHCJabbaSVDeWinterTMMendizabalMAnastasPTJordtSEZimmermanJB. 2019. Formation of flavorant-propylene glycol adducts with novel toxicological properties in chemically unstable e-cigarette liquids. Nicotine Tob Res. 21(9):1248–1258.
Federal Trade Commission. 2018. Smokeless tobacco report for 2016. Washington (DC): Federal Trade Commission.
24.
FisherMATaylorGWTilashalskiKR. 2005. Smokeless tobacco and severe active periodontal disease, NHANES III. J Dent Res. 84(4):705–710.
25.
Food and Drug Administration. 2017. Tobacco product standard for N-nitrosonornicotine level in finished smokeless tobacco products (proposed rule). 21 CFR Part 1132 (Docket No. FDA-2016-N-2527). Federal Register. 82(13):8004–8053. http://www.govinfo.gov/content/pkg/FR-2017-01-23/pdf/2017-01030.pdf.
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GhoshACoakleyRCMascenikTRowellTRDavisESRogersKWebsterMJDangHHerringLESassanoMFet al. 2018. Chronic e-cigarette exposure alters the human bronchial epithelial proteome. Am J Respir Crit Care Med. 198(1):67–76.
27.
GreerROJr.2011. Oral manifestations of smokeless tobacco use. Otolaryngol Clin North Am. 44(1):31–56.
28.
HaniokaTOjimaMTanakaK. 2014. Daily smokingmayindependently predict caries development in adults. J Evid Based Dent Pract. 14(3):151–153.
HatsukamiDKStepanovISeversonHJensenJALindgrenBHornKKhariwalaSSMartinJCarmellaSGMurphySEet al. 2015. Evidence supporting product standards for carcinogens in smokeless tobacco products. Cancer Prev Res. 8(1):20–26.
31.
HechtSS. 1998. Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines. Chem Res Toxicol. 11(6):559–603.
32.
HechtSS. 2012. Research opportunities related to establishing standards for tobacco products under the Family Smoking Prevention and Tobacco Control Act. Nicotine Tob Res. 14(1):18–28.
33.
HechtSSYuanJMHatsukamiD. 2010. Applying tobacco carcinogen and toxicant biomarkers in product regulation and cancer prevention. Chem Res Toxicol. 23(6):1001–1008.
34.
HuangRLiMGregoryRL. 2011. Bacterial interactions in dental biofilm. Virulence. 2(5):435–444.
35.
HuangRLiMGregoryRL. 2012. Effect of nicotine on growth and metabolism ofStreptococcus mutans. Eur J Oral Sci. 120(4):319–325.
International Agency for Research on Cancer. 2004. Tobacco smoke and involuntary smoking.Lyon (France): International Agency for Research on Cancer. IARC monographs on the evaluation of carcinogenic risks to humans, vol. 83.
38.
International Agency for Research on Cancer. 2007. Smokeless tobacco and some tobacco-specific N-nitrosamines. Lyon (France): International Agency for Research on Cancer. IARC monographs on the evaluation of carcinogenic risks to humans, vol. 89.
39.
International Agency for Research on Cancer. 2010. Some non-heterocyclic polycyclic aromatic hydrocarbons and some related exposures. Lyon (France): International Agency for Research on Cancer. IARC monographs on the evaluation of carcinogenic risks to humans, vol. 92.
40.
International Agency for Research on Cancer. 2012. Personal habits and indoor combustions. Lyon (France): International Agency for Research on Cancer. IARC monographs on the evaluation of carcinogenic risks to humans, vol. 100E.
41.
JaspersI. 2014. Cigarette smoke effects on innate immune mechanisms in the nasal mucosa: potential effects on the microbiome. Ann Am Thorac Soc. 11(Suppl 1):S38–S42.
42.
JohnsonNWBainCA; EU-Working Group on Tobacco and Oral Health. 2000. Tobacco and oral disease. Br Dent J. 189(4):200–206.
43.
JohnstonLDMiechRAO’MalleyPMBachmanJGSchulenbergJF. 2018. Demographic subgroup trends among adolescents in the use of various licit and illicit drugs, 1975–2017. Ann Arbor (MI): Institute for Social Research. Monitoring the future occasional paper 90.
44.
KnezevichAMuzicJHatsukamiDKHechtSSStepanovI. 2013. Nornicotine nitrosation in saliva and its relation to endogenous synthesis of N′-nitrosonornicotine in humans. Nicotine Tob Res. 15(2):591–595.
45.
KostyginaGLingPM. 2016. Tobacco industry use of flavourings to promote smokeless tobacco products. Tob Control. 25Suppl 2:ii40–ii49.
46.
LiMHuangRZhouXQiuWXuXGregoryRL. 2016. Effect of nicotine on cariogenic virulence of Streptococcus mutans. Folia Microbiol. 61(6):505–512.
47.
LiuSWuTZhouXZhangBHuoSYangYZhangKChengLXuXLiM. 2018. Nicotine is a risk factor for dental caries: an in vivo study. J Dent Sci. 13(1):30–36.
48.
MartinEMClappPWRebuliMEPawlakEAGlista-BakerEBenowitzNLFryRCJaspersI. 2016. E-cigarette use results in suppression of immune and inflammatory-response genes in nasal epithelial cells similar to cigarette smoke. Am J Physiol Lung Cell Mol Physiol. 311(1):L135–L144.
49.
National Cancer Institute, Centers for Disease Control and Prevention. 2014. Smokeless tobacco and public health: a global perspective. Bethesda (MD): US Department of Health and Human Services. NIH publication 14-7983.
50.
OliverAJJensenJAVogelRIAndersonAJHatsukamiDK. 2013. Flavored and nonflavored smokeless tobacco products: rate, pattern of use, and effects. Nicotine Tob Res. 15(1):88–92.
51.
ReidelBRadicioniGClappPWFordAAAbdelwahabSRebuliMEHaridassPAlexisNEJaspersIKesimerM. 2018. E-cigarette use causes a unique innate immune response in the lung, involving increased neutrophilic activation and altered mucin secretion. Am J Respir Crit Care Med. 197(4):492–501.
52.
RobertsonPBWalshMMGreeneJC. 1997. Oral effects of smokeless tobacco use by professional baseball players. Adv Dent Res. 11(3):307–312.
53.
SalamancaJCMunhenzvaIEscobedoJOJensenRPShawACampbellRLuoWPeytonDHStronginRM. 2017. Formaldehyde hemiacetal sampling, recovery, and quantification from electronic cigarette aerosols. Sci Rep. 7(1):11044.
54.
SleimanMLogueJMMontesinosVNRussellMLLitterMIGundelLADestaillatsH. 2016. Emissions from electronic cigarettes: key parameters affecting the release of harmful chemicals. Environ Sci Technol. 50(17):9644–9651.
55.
StepanovIHatsukamiD. 2016. Call to establish constituent standards for smokeless tobacco products. Tob Regul Sci. 2(1):9–30.
56.
TomarSLAlpertHRConnollyGN. 2010. Patterns of dual use of cigarettes and smokeless tobacco among US males: findings from national surveys. Tob Control. 19(2):104–109.
57.
TomarSLAsmaS. 2000. Smoking-attributable periodontitis in the United States: findings from NHANES III. J Periodontol. 71(5):743–751.
58.
TomarSLHenningfieldJE. 1997. Review of the evidence that pH is a determinant of nicotine dosage from oral use of smokeless tobacco. Tob Control. 6(3):219–225.
59.
TomarSLWinnDM. 1999. Chewing tobacco use and dental caries among US men. J Am Dent Assoc. 130(11):1601–1610.
60.
US Department of Health and Human Services. 1986. The health consequences of using smokeless tobacco: a report of the advisory committee to the Surgeon General. Bethesda (MD): US Department of Health and Human Services. NIH publication86-2874.
61.
US Department of Health and Human Services. 2004. The health consequences of smoking: a report of the Surgeon General. Atlanta (GA): US Department of Health and Human Services.
62.
US Department of Health and Human Services. 2014. The health consequences of smoking: 50 years of progress. A report of the Surgeon General. Atlanta (GA): US Department of Health and Human Services.
63.
VillantiACJohnsonALAmbroseBKCummingsKMStantonCARoseSWFeirmanSPTworekCGlasserAMPearsonJLet al. 2017. Flavored tobacco product use in youth and adults: findings from the first wave of the PATH Study (2013–2014). Am J Prev Med. 53(2):139–151.
64.
WagenknechtDRBalHaddadAAGregoryRL. 2018. Effects of nicotine on oral microorganisms, human tissues, and the interactions between them. Curr Oral Health Rep. 5:78–87.
65.
WarnakulasuriyaSDietrichTBornsteinMMCasals PeidróEPreshawPMWalterCWennströmJLBergströmJ. 2010. Oral health risks of tobacco use and effects of cessation. Int Dent J. 60(1):7–30.
66.
YuanJMKnezevichADWangRGaoYTHechtSSStepanovI. 2011. Urinary levels of the tobacco-specific carcinogen N′-nitrosonornicotine and its glucuronide are strongly associated with esophageal cancer risk in smokers. Carcinogenesis. 32(9):1366–1371.
