The load-bearing dentoalveolar fibrous joint is composed of biomechanically active periodontal ligament (PDL), bone, cementum, and the synergistic entheses of PDL-bone and PDL-cementum. Physiologic and pathologic loads on the dentoalveolar fibrous joint prompt natural shifts in strain gradients within mineralized and fibrous tissues and trigger a cascade of biochemical events within the widened and narrowed sites of the periodontal complex. This review highlights data from in situ biomechanical simulations that provide tooth movements relative to the alveolar socket. The methods and subsequent results provide a reasonable approximation of strain-regulated biochemical events resulting in mesial mineral formation and distal resorption events within microanatomical regions at the ligament-tethered/enthesial ends. These biochemical events, including expressions of biglycan, decorin, chondroitin sulfated neuroglial 2, osteopontin, and bone sialoprotein and localization of various hypertrophic progenitors, are observed at the alkaline phosphatase–positive widened site, resulting in mineral formation and osteoid/cementoid layers. On the narrowed side, tartrate-resistant acid phosphatase regions can lead to a sequence of clastic activities resulting in resorption pits in bone and cementum. These strain-regulated biochemical and subsequently biomineralization events in the load-bearing periodontal complex are critical for maintenance of the periodontal space and overall macroscale joint biomechanics.
CateTNanciA.2013. Ten Cate’s—oral histology: development, structure, and function. St. Louis, MO: Elsevier.
8.
CattaneoPMDalstraMMelsenB.2005. The finite element method: a tool to study orthodontic tooth movement. J Dent Res. 84(5):428–433.
9.
ChibaMYamaneAOhshimaSKomatsuK.1990. In vitro measurement of regional differences in the mechanical properties of the periodontal ligament in the rat mandibular incisor. Arch Oral Biol. 35(2):153–161.
10.
ChiuRLiWHerberRPMarshallSJYoungMHoSP. 2012. Effects of biglycan on physico-chemical properties of ligament-mineralized tissue attachment sites. Arch Oral Biol. 57(2):177–187.
11.
ChristiansenRLBurstoneCJ. 1969. Centers of rotation within the periodontal space. Am J Orthod. 55(4):353–369.
12.
DaeglingDJRavosaMJJohnsonKRHylanderWL. 1992. Influence of teeth, alveoli, and periodontal ligaments on torsional rigidity in human mandibles. Am J Phys Anthropol. 89(1):59–72.
13.
DischerDDongCFredbergJJGuilakFIngberDJanmeyPKammRDSchmid-SchonbeinGWWeinbaumS.2009. Biomechanics: cell research and applications for the next decade. Ann Biomed Eng. 37(5):847–859.
14.
GarletTPCoelhoUSilvaJSGarletGP. 2007. Cytokine expression pattern in compression and tension sides of the periodontal ligament during orthodontic tooth movement in humans. Eur J Oral Sci. 115(5):355–362.
15.
GeorgeAVeisA.2008. Phosphorylated proteins and control over apatite nucleation, crystal growth, and inhibition. Chem Rev. 108(11):4670–4693.
16.
GrandfieldKHerberRPChenLDjomehriSTamCLeeJHBrownEWoolwineWR3rdCurtisDRyderMet al. 2015. Strain-guided mineralization in the bone-PDL-cementum complex of a rat periodontium. Bone Rep. 3:20–31.
17.
HallmonWW.1999. Occlusal trauma: effect and impact on the periodontium. Ann Periodontol. 4(1):102–108.
18.
HerringSW.1976. The dynamics of mastication in pigs. Arch Oral Biol. 21(8):473–480.
19.
HiiemaeKM.1967. Masticatory function in the mammals. J Dent Res. 46(5):883–893.
20.
HoSPKuryloMPFongTKLeeSSWagnerHDRyderMIMarshallGW. 2010. The biomechanical characteristics of the bone–periodontal ligament–cementum complex. Biomaterials. 31(25):6635–6646.
21.
HoSPKuryloMPGrandfieldKHurngJHerberRPRyderMIAltoeVAloniSFengJQWebbSet al. 2013. The plastic nature of the human bone–periodontal ligament–tooth fibrous joint. Bone. 57(2):455–467.
22.
HylanderWL. 1979. The functional significance of primate mandibular form. J Morphol. 160(2):223–240.
23.
IngberDE.1997. Tensegrity: the architectural basis of cellular mechanotransduction. Annu Rev Physiol. 59:575–599.
24.
IngberDE.2003. Tensegrity II: how structural networks influence cellular information processing networks. J Cell Sci. 116(Pt 8):1397–1408.
25.
JangATLinJDSeoYEtchinSMerkleAFaheyKHoSP. 2014. In situ compressive loading and correlative noninvasive imaging of the bone–periodontal ligament–tooth fibrous joint. J Vis Exp. 85. doi:10.3791/51147.
JangIGKimIYKwakBB. 2009. Analogy of strain energy density based bone-remodeling algorithm and structural topology optimization. J Biomech Eng. 131(1):011012.
28.
JantaratJPalamaraJEMesserHH. 2001. An investigation of cuspal deformation and delayed recovery after occlusal loading. J Dent. 29(5):363–370.
29.
KikuchiMKoriothTWHannamAG. 1997. The association among occlusal contacts, clenching effort, and bite force distribution in man. J Dent Res. 76(6):1316–1325.
30.
KiliaridisS.1986a. Masticatory muscle function and craniofacial morphology: an experimental study in the growing rat fed a soft diet. Swed Dent J Suppl. 36:1–55.
31.
KiliaridisS.1986b. The relationship between masticatory function and craniofacial morphology: III. The eruption pattern of the incisors in the growing rat fed a soft diet. Eur J Orthod. 8(2):71–79.
32.
KoivumaaKKMäkiläEHonkaO.1971. Histological changes in human periodontium of teeth in masticatory hyper- and hypofunction. Suom Hammaslaak Toim. 67(2):122–136.
33.
KomatsuK.1988. In vitro mechanics of the periodontal ligament in impeded and unimpeded rat mandibular incisors. Arch Oral Biol. 33(11):783–791.
34.
KrishnanV.2005. Critical issues concerning root resorption: a contemporary review. World J Orthod. 6(1):30–40.
35.
KrishnanVDavidovitchZ.2009. On a path to unfolding the biological mechanisms of orthodontic tooth movement. J Dent Res. 88(7):597–608.
36.
KuryloMPGrandfieldKMarshallGWAltoeVAloniSHoSP. 2016. Effect of proteoglycans at interfaces as related to location, architecture, and mechanical cues. Arch Oral Biol. 63:82–92.
37.
LeeJHPryceBASchweitzerRRyderMIHoSP. 2015. Differentiating zones at periodontal ligament–bone and periodontal ligament–cementum entheses. J Periodontal Res. 50(6):870–880.
38.
LinJDOzcobanHGreeneJPJangATDjomehriSIFaheyKPHunterLLSchneiderGAHoSP. 2013. Biomechanics of a bone–periodontal ligament–tooth fibrous joint. J Biomech. 46(3):443–449.
39.
LukinmaaPLMackieEJThesleffI.1991. Immunohistochemical localization of the matrix glycoproteins—tenascin and the ED-sequence-containing form of cellular fibronectin—in human permanent teeth and periodontal ligament. J Dent Res. 70(1):19–26.
40.
MargvelashviliAZollikoferCPLordkipanidzeDPeltomäkiTPoncedeLeónMS. 2013. Tooth wear and dentoalveolar remodeling are key factors of morphological variation in the Dmanisi mandibles. Proc Natl Acad Sci U S A. 110(43):17278–17283.
41.
McCullochCALekicPMcKeeMD. 2000. Role of physical forces in regulating the form and function of the periodontal ligament. Periodontol 2000. 24:56–72.
42.
NavehGRShaharRBrumfeldVWeinerS.2012. Tooth movements are guided by specific contact areas between the tooth root and the jaw bone: a dynamic 3D microCT study of the rat molar. J Struct Biol. 177(2):477–483.
43.
NiesMRoJY. 2004. Bite force measurement in awake rats. Brain Res Brain Res Protoc. 12(3):180–185.
44.
PalAChenLYangLYangFMengBJheonAHHoSP. 2017. Micro-anatomical responses in the periodontal complex to calibrated orthodontics forces on the crown. Orthod Craniofac Res. 20 Suppl 1:100–105.
45.
PopowicsTERensbergerJMHerringSW. 2004. Enamel microstructure and microstrain in the fracture of human and pig molar cusps. Arch Oral Biol. 49(8):595–605.
46.
ProvatidisCG. 1999. Numerical estimation of the centres of rotation and resistance in orthodontic tooth movement. Comput Methods Biomech Biomed Engin. 2(2):149–156.
47.
QianLTodoMMoritaYMatsushitaYKoyanoK.2009. Deformation analysis of the periodontium considering the viscoelasticity of the periodontal ligament. Dent Mater. 25(10):1285–1292.
48.
SchneiderBJMeyerJ.1965. Experimental studies on the interrelations of condylar growth and alveolar bone formation. Angle Orthod. 35:187–199.
49.
ThomasNRPeytonSC. 1983. An electromyographic study of mastication in the freely-moving rat. Arch Oral Biol. 28:939–945.
50.
TomesCS.1882. A manual of dental anatomy human and comparative. London (UK): J & A Churchill.
51.
TurnerCHPavalkoFM. 1998. Mechanotransduction and functional response of the skeleton to physical stress: the mechanisms and mechanics of bone adaptation. J Orthop Sci. 3(6):346–355.
52.
VinyardCRavosaMJChristineW.2008. Primate craniofacial function and biology. In: TuttleRH editor. Developments in primatology: progress and prospects. New York (NY): Springer Science + Business Media, LLC.
53.
WangRZWeinerS.1998. Strain-structure relations in human teeth using moire fringes. J Biomech. 31(2):135–141.
54.
WeinmannJP.1955. Bone formation and bone resorption. Oral Surg Oral Med Oral Pathol. 8(10):1074–1078.
55.
WoodJDWangRWeinerSPashleyDH. 2003. Mapping of tooth deformation caused by moisture change using moire interferometry. Dent Mater. 19(3):159–166.
56.
YamamotoS.1996. The effects of food consistency on maxillary growth in rats. Eur J Orthod. 18(6):601–615.
57.
ZaslanskyPCurreyJDFriesemAAWeinerS.2005. Phase shifting speckle interferometry for determination of strain and Young’s modulus of mineralized biological materials: a study of tooth dentin compression in water. J Biomed Opt. 10(2):024020.
58.
ZhangDMaoSLuCRombergEArolaD.2009. Dehydration and the dynamic dimensional changes within dentin and enamel. Dent Mater. 25(7):937–945.
59.
ZieglerAKeiligLKawarizadehAJagerABourauelC.2005. Numerical simulation of the biomechanical behaviour of multi-rooted teeth. Eur J Orthod. 27(4):333–339.
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