Periodontitis is an inflammatory disease that causes loss of the tooth-supporting apparatus, including periodontal ligament, cementum, and alveolar bone. A broad range of treatment options is currently available to restore the structure and function of the periodontal tissues. A regenerative approach, among others, is now considered the most promising paradigm for this purpose, harnessing the unique properties of stem cells. How to make full use of the body’s innate regenerative capacity is thus a key issue. While stem cells and bioactive factors are essential components in the regenerative processes, matrices play pivotal roles in recapitulating stem cell functions and potentiating therapeutic actions of bioactive molecules. Moreover, the positions of appropriate bioactive matrices relative to the injury site may stimulate the innate regenerative stem cell populations, removing the need to deliver cells that have been manipulated outside of the body. In this topical review, we update views on advanced designs of biomatrices—including mimicking of the native extracellular matrix, providing mechanical stimulation, activating cell-driven matrices, and delivering bioactive factors in a controllable manner—which are ultimately useful for the regenerative therapy of periodontal tissues.
BanjarAAMealeyBL (2013). A clinical investigation of demineralized bone matrix putty for treatment of periodontal bony defects in humans. Int J Periodontics Restorative Dent33:567-573.
2.
BansalCBhartiV (2013). Evaluation of efficacy of autologous platelet-rich fibrin with demineralized-freeze dried bone allograft in the treatment of periodontal intrabony defects. J Indian Soc Periodontol17:361-366.
3.
ChenFMMaZWWangQTWuZF (2009a). Gene delivery for periodontal tissue engineering: current knowledge–future possibilities. Curr Gene Ther9:248-266.
4.
ChenFMChenRWangXJSunHHWuZF (2009b). In vitro cellular responses to scaffolds containing two microencapsulated growth factors. Biomaterials30:5215-5224.
5.
ChenFMZhangJZhangMAnYChenFWuZF (2010). A review on endogenous regenerative technology in periodontal regenerative medicine. Biomaterials31:7892-7927.
6.
CostaPFVaquetteCZhangQReisRLIvanovskiSHutmacherDW (2014). Advanced tissue engineering scaffold design for regeneration of the complex hierarchical periodontal structure. J Clin Periodontol41:283-294.
7.
CookeJWSarmentDPWhitesmanLAMillerSEJinQLynchSE. (2006). Effect of rhPDGF-BB delivery on mediators of periodontal wound repair. Tissue Eng12:1441-1450.
8.
CreeperFLichanskaAMMarshallRISeymourGJIvanovskiS (2009). The effect of platelet-rich plasma on osteoblast and periodontal ligament cell migration, proliferation and differentiation. J Periodontal Res44:258-265.
9.
DarbyIBMorrisKH (2013). A systematic review of the use of growth factors in human periodontal regeneration. J Periodontol84:465-476.
10.
DorozhkinSV (2010). Bioceramics of calcium orthophosphates. Biomaterials31:1465-1485.
11.
FranceschiRT (2005). Biological approaches to bone regeneration by gene therapy. J Dent Res84:1093-1103.
12.
GungormusMOrenEEHorstJAFongHHnilovaMSomermanMJ. (2012). Cementomimetics—constructing a cementum-like biomineralized microlayer via amelogenin-derived peptides. Int J Oral Sci4:69-77.
13.
GurinskyBSMillsMPMellonigJT (2004). Clinical evaluation of demineralized freeze-dried bone allograft and enamel matrix derivative versus enamel matrix derivative alone for the treatment of periodontal osseous defects in humans. J Periodontol75:1309-1318.
14.
HeGDahlTVeisAGeorgeA (2003). Nucleation of apatite crystals in vitro by self-assembled dentin matrix protein 1. Nat Mater2:552-558.
15.
HorstOVChavezMGJheonAHDesaiTKleinOD (2012). Stem cell and biomaterials research in dental tissue engineering and regeneration. Dent Clin North Am56:495-520.
16.
IwataTYamatoMTsuchiokaHTakagiRMukobataSWashioK. (2009). Periodontal regeneration with multi-layered periodontal ligament-derived cell sheets in a canine model. Biomaterials30:2716-2723.
17.
JinQMZhaoMWebbSABerryJESomermanMJGiannobileWV (2003). Cementum engineering with three-dimensional polymer scaffolds. J Biomed Mater Res A67:54-60.
18.
KaiglerDPagniGParkCHBraunTMHolmanLAYiE. (2013). Stem cell therapy for craniofacial bone regeneration: a randomized, controlled feasibility trial. Cell Transplant22:767-777.
19.
KraftDCBindslevDAMelsenBAbdallahBMKassemMKlein-NulendJ (2010). Mechanosensitivity of dental pulp stem cells is related to their osteogenic maturity. Eur J Oral Sci118:29-38.
20.
LeeJHParkJHEl-FiqiAKimJHYunYRJangJH. (2014). Biointerface control of electrospun fiber scaffolds for bone regeneration: engineered protein link to mineralized surface. Acta Biomater10:2750-2761.
21.
LiBChenXGuoBWangXFanHZhangX (2009). Fabrication and cellular biocompatibility of porous carbonated biphasic calcium phosphate ceramics with a nanostructure. Acta Biomater5:134-143.
22.
LickorishDRamshawJAMWerkmeisterJAGlattauerVHowlettCR (2004). Collagen-hydroxyapatite composite prepared by biomimetic process. J Biomed Mater Res A68:19-27.
23.
LinNHGronthosSBartoldPM (2009). Stem cells and future periodontal regeneration. Periodontol200051:239-251.
24.
LiuXMaPX (2004). Polymeric scaffolds for bone tissue engineering. Ann Biomed Eng32:477-486.
25.
LiuXWonYMaPX (2006). Porogen-induced surface modification of nano-fibrous poly(L-lactic acid) scaffolds for tissue engineering. Biomaterials27:3980-3987.
MarchesanJTScanlonCSSoehrenSMatsuoMKapilaYL (2011). Implications of cultured periodontal ligament cells for the clinical and experimental setting: a review. Arch Oral Biol56:933-943.
28.
MayaharaKKobayashiYTakimotoKSuzukiNMitsuiNShimizuN (2007). Aging stimulates cyclooxygenase-2 expression and prostaglandin E2 production in human periodontal ligament cells after the application of compressive force. J Periodontal Res42:8-14.
29.
MironRJBosshardtDDLaugischODardMGemperliACBuserD. (2013). In vitro evaluation of demineralized freeze-dried bone allograft in combination with enamel matrix derivative. J Periodontol84:1646-1654.
30.
MiyajiHSugayaTIbeKIshizukaRTokunagaKKawanamiM (2010). Root surface conditioning with bone morphogenetic protein-2 facilitates cementum-like tissue deposition in beagle dogs. J Periodontal Res45:658-663.
31.
MoreauJLWeirMDXuHH (2009). Self-setting collagen-calcium phosphate bone cement: mechanical and cellular properties. J Biomed Mater Res A91:605-613.
32.
NanciABosshardtDD (2006). Structure of periodontal tissues in health and disease. Periodontol200040:11-28.
33.
NudelmanFPieterseKGeorgeABomansPHFriedrichHBrylkaLJ. (2010). The role of collagen in bone apatite formation in the presence of hydroxyapatite nucleation inhibitors. Nat Mater9:1004-1009.
34.
ParkCHRiosHFJinQSugaiJVPadial-MolinaMTautAD. (2012). Tissue engineering bone-ligament complexes using fiber-guiding scaffolds. Biomaterials33:137-145.
35.
ParkCHRiosHFTautADPadial-MolinaMFlanaganCLPilipchukSP. (2014). Image-based, fiber guiding scaffolds: a platform for regenerating tissue interfaces. Tissue Eng Part C Methods [Epub ahead of print 12/14/2013] (PMID: 24188695).
36.
PerezRAGinebraMP (2013). Injectable collagen/α-tricalcium phosphate cement: collagen–mineral phase interactions and cell response. J Mater Sci Mater Med24:381-393.
37.
PiemonteseMAsprielloSDRubiniCFerranteLProcacciniM (2008). Treatment of periodontal intrabony defects with demineralized freeze-dried bone allograft in combination with platelet-rich plasma: a comparative clinical trial. J Periodontol79:802-810.
RaabMShinJWDischerDE (2010). Matrix elasticity in vitro controls muscle stem cell fate in vivo. Stem Cell Res Ther1:38.
40.
SacharAStromTASan MiguelSSerranoMJSvobodaKKLiuX (2014). Cell-matrix and cell-cell interactions of human gingival fibroblasts on three-dimensional nanofibrous gelatin scaffolds. J Tissue Eng Regen Med [Epub ahead of print 8/13/2012] (PMID: 22888047).
SawyerAAHennessyKMBellisSL (2005). Regulation of mesenchymal stem cell attachment and spreading on hydroxyapatite by RGD peptides and adsorbed serum proteins. Biomaterials26:1467-1475.
43.
SchwartzZSomersAMellonigJTCarnesDLJrWozneyJMDeanDD. (1998). Addition of human recombinant bone morphogenetic protein-2 to inactive commercial human demineralized freeze-dried bone allograft makes an effective composite bone inductive implant material. J Periodontol69:1337-1345.
44.
ShueLYufengZMonyU (2012). Biomaterials for periodontal regeneration: a review of ceramics and polymers. Biomatter2:271-277.
45.
SoranZAydınRSTGümüşderelioğluM (2012). Chitosan scaffolds with BMP-6 loaded alginate microspheres for periodontal tissue engineering. J Microencapsul29:770-780.
46.
SuhJKMatthewHW (2000). Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: a review. Biomaterials21:2589-2598.
47.
SundararajSCThomasM VPeyyalaRDziublaTDPuleoDA (2013). Design of a multiple drug delivery system directed at periodontitis. Biomaterials34:8835-8842.
48.
TabaMJrJinQSugaiJVGiannobileWV (2005). Current concepts in periodontal bioengineering. Orthod Craniofac Res8:292-302.
49.
TasAC (2000). Synthesis of biomimetic Ca-hydroxyapatite powders at 37°C in synthetic body fluids. Biomaterials21:1429-1438.
50.
TeixeiraSFernandesMHFerrazMPMonteiroFJ (2010). Proliferation and mineralization of bone marrow cells cultured on macroporous hydroxyapatite scaffolds functionalized with collagen type I for bone tissue regeneration. J Biomed Mater Res A95:1-8.
51.
ThoratMPradeepARPallaviB (2011). Clinical effect of autologous platelet-rich fibrin in the treatment of intra-bony defects: a controlled clinical trial. J Clin Periodontol38:925-932.
52.
TsumanumaYIwataTWashioKYoshidaTYamadaATakagiR. (2011). Comparison of different tissue-derived stem cell sheets for periodontal regeneration in a canine 1-wall defect model. Biomaterials32:5819-5825.
53.
VaquetteCFanWXiaoYHamletSHutmacherDWIvanovskiS (2012). A biphasic scaffold design combined with cell sheet technology for simultaneous regeneration of alveolar bone/periodontal ligament complex. Biomaterials33:5560-5573.
54.
VaquetteCIvanovskiSHamletSMHutmacherDW (2013). Effect of culture conditions and calcium phosphate coating on ectopic bone formation. Biomaterials34:5538-5551.
55.
WeiGJinQGiannobileWVMaPX (2007). The enhancement of osteogenesis by nano-fibrous scaffolds incorporating rhBMP-7 nanospheres. Biomaterials28:2087-2096.
56.
WeidenhamerNKTranquilloRT (2013). Influence of cyclic mechanical stretch and tissue constraints on cellular and collagen alignment in fibroblast-derived cell sheets. Tissue Eng Part C Methods19:386-395.
57.
YilgorPTuzlakogluKReisRLHasirciNHasirciV (2009). Incorporation of a sequential BMP-2/BMP-7 delivery system into chitosan-based scaffolds for bone tissue engineering. Biomaterials30:3551-3559.
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