Bernhard Guggenheim is a distinguished leader in oral microbiology and immunology and a recipient of many honors. This article outlines his background and scientific career and illuminates some of his important contributions to dental research. At the age of 75, he continues to scrutinize established paradigms and unremittingly fosters demanding biofilm research.
ArmitageGCRobertsonPB (2009). The biology, prevention, diagnosis and treatment of periodontal diseases: scientific advances in the United States. J Am Dent Assoc140(Suppl 1):36-43.
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BelibasakisGNMeierAGuggenheimBBostanciN (2011). Oral biofilm challenge regulates the RANKL-OPG system in periodontal ligament and dental pulp cells. Microb Pathog50:6-11.
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Gaegauf-ZollingerRBurckhardtJJGmürRGuggenheimB (1982). Cell-mediated cytotoxicity against rat fibroblasts induced by Actinomyces viscosus. Infect Immun37:710-719.
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GmürRGuggenheimB (1994). Interdental supragingival plaque—a natural habitat of Actinobacillus actinomycetemcomitans, Bacteroides forsythus, Campylobacter rectus, and Prevotella nigrescens. J Dent Res73:1421-1428.
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GmürRHrodekKSaxerUPGuggenheimB (1986). Double-blind analysis of the relation between adult periodontitis and systemic host response to suspected periodontal pathogens. Infect Immun52:768-776.
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GmürRStrubJRGuggenheimB (1989). Prevalence of Bacteroides forsythus and Bacteroides gingivalis in subgingival plaque of prosthodontically treated patients on short recall. J Periodontal Res24:113-120.
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GuggenheimB (1966). Ueber die Wirkung verschiedener Speichelfraktionen auf die Atmung von Mundbakterien. Helv Odontol Acta10(Suppl 3):59-93.
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GuggenheimBHallerR (1972). Purification and properties of an alpha (1-3) glucanohydrolase from Trichoderma harzianum. J Dent Res51:394-402.
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GuggenheimBNewbrunE (1969). Extracellular glucosyltransferase activity of an H.S. strain of Streptococcus mutans. Helv Odontol Acta13:84-97.
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GuggenheimBSchroederHE (1967). Biochemical and morphological aspects of extracellular polysaccharides produced by cariogenic streptococci. Helv Odontol Acta11:131-152.
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GuggenheimBKönigKHerzogEMühlemannHR (1966). Cariogenicity of different dietary carbohydrates tested on rats in relative gnotobiosis with a streptococcus producing extracellular polysaccharide. Helv Odontol Acta10:101-113.
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GuggenheimBSchmidRAeschlimannJMBerrocalRNeeserJR (1999). Powdered milk micellar casein prevents oral colonization by Streptococcus sobrinus and dental caries in rats: a basis for the caries-protective effect of dairy products. Caries Res33:446-454.
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GuggenheimBGuggenheimMGmürRGiertsenEThurnheerT (2004). Application of the Zürich biofilm model to problems of cariology. Caries Res38:212-222.
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GuggenheimBGmürRGaliciaJCStathopoulouPBenakanakereMRMeierA. (2009). In vitro modeling of host-parasite interactions: the ‘subgingival’ biofilm challenge of primary human epithelial cells. BMC Microbiol9:280.
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GuggenheimMThurnheerTGmürRGiovanoliPGuggenheimB (2011). Validation of the Zürich burn-biofilm model. Burns37:1125-1133.
ShapiroSGiertsenEGuggenheimB (2002). An in vitro oral biofilm model for comparing the efficacy of antimicrobial mouthrinses. Caries Res36:93-100.
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ThurnheerTGmürRShapiroSGuggenheimB (2003). Mass transport of macromolecules within an in vitro model of supragingival plaque. Appl Environ Microbiol69:1702-1709.
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WyssC (1992). Growth of Porphyromonas gingivalis, Treponema denticola, T. pectinovorum, T. socranskii, and T. vincentii in a chemically defined medium. J Clin Microbiol30:2225-2229.
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WyssCChoiB-KSchüpbachPMoterAGuggenheimB (1999). Treponema lecithinolyticum sp. nov., a small saccharolytic spirochaete with phospholipase A and C activities associated with periodontal diseases. Int J Syst Bacteriol49(Pt 4):1329-1339.
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ZijngeVAmmannTThurnheerTGmürR (2012). Subgingival biofilm structure. Front Oral Biol15:1-16.
