Dental Development in Hemifacial Microsomia

Abstract

Hemifacial microsomia (HFM) is a congenital disorder marked by facial asymmetry. Whether facial asymmetry accounts for asymmetrical dental development is unknown. There are few data on dental development relative to mandibular development or severity of HFM, or on development over time. We hypothesized that when mandibular development was severely disturbed, local dental development was also affected. We compared dental development scores between affected and non-affected mandibular sides in patients with HFM (n = 84) and compared these data with those collected from Dutch control children (n = 451). Logistic functions were constructed for dental age over time for all four Pruzansky/Kaban types. The results showed a tendency toward delayed dental development in Pruzansky/Kaban types IIb and III at younger ages. The temporary delay of tooth formation in patients with severe forms of HFM and the distribution of agenic teeth suggest an interaction between mandibular and dental development.

Keywords

facial asymmetry dental development hemifacial microsomia

Get full access to this article

View all access options for this article.

References

Cobourne

Sharpe

(2003). Tooth and jaw: molecular mechanisms of patterning in the first branchial arch. Arch Oral Biol 48:1-14.

Demirjian

(1993). Dental development. CD-ROM, Silver Platter Education (computer program), Montreal, Canada: University of Montreal.

Demirjian

Goldstein

Tanner

(1973). A new system of dental age assessment. Hum Biol 45:211-227.

Farias

Vargervik

(1998). Tooth size and morphology in hemifacial microsomia. Int J Paediatr Dent 8:197-201.

Foerst-Potts

Sadler

(1997). Disruption of Msx-1 and Msx-2 reveals roles for these genes in craniofacial, eye, and axial development. Dev Dyn 209:70-84.

Gorlin

(1990). Syndromes of the head and neck. 3rd ed. London, UK: Oxford University Press.

Gorlin

Jue

Jacobsen

Goldschmidt

(1963). Oculoauriculovertebral dysplasia. J Pediatr 63:991-999.

Gorlin

Cohen

Hennekam

(2001). Oculo-auriculo-vertebral spectrum (hemifacial microsomia, Goldenhar syndrome). In: Syndromes of the head and neck. 4th ed. New York, NY: Oxford University Press, pp. 790-798.

Grabb

(1965). The first and second branchial arch syndrome. Plast Reconstr Surg 36:485-508.

10.

Grayson

Boral

Eisig

Kolber

McCarthy

(1983). Unilateral craniofacial microsomia. Part I. Mandibular analysis. Am J Orthod 84:225-230.

11.

Hägg

Matsson

(1985). Dental maturity as an indicator of chronological age: the accuracy and precision of three methods. Eur J Orthod 7:25-34.

12.

Hartsfield

(2007). Review of the etiologic heterogeneity of the oculo-auriculo-vertebral spectrum (hemifacial microsomia). Orthod Craniofac Res 10:121-128.

13.

Jackson

(2004). Analysis and treatment of hemifacial microsomia. Eur J Plast Surg 27:159-170.

14.

Kaban

Moses

Mulliken

(1988). Surgical correction of hemifacial microsomia in the growing child. Plast Reconstr Surg 82:9-19.

15.

Kelberman

Tyson

Chandler

McInerney

Slee

Albert

. (2001). Hemifacial microsomia: progress in understanding the genetic basis of a complex malformation syndrome. Hum Genet 109:638-645.

16.

Lee

Kim

Yang

Kim

Chi

(2001). Prenatal development of the human mandible. Anat Rec 263:314-325.

17.

Leurs

Wattel

Aartman

Etty

Prahl-Andersen

(2005). Dental age in Dutch children. Eur J Orthod 27:309-314.

18.

Loevy

Shore

(1985). Dental maturation in hemifacial microsomia. J Craniofac Genet Dev Biol Suppl 1:267-272.

19.

Maber

Liversidge

Hector

(2006). Accuracy of age estimation of radiographic methods using developing teeth. Forensic Sci Int 159(Suppl 1):68-73.

20.

Maruko

Hayes

Evans

Padwa

Mulliken

(2001). Hypodontia in hemifacial microsomia. Cleft Palate Craniofac J 38:15-19.

21.

Nanci

(2007). Ten Cate’s oral histology. 7th ed. St. Louis, MO: C.V. Mosby and Company.

22.

Poswillo

(1973). The pathogenesis of the first and second branchial arch syndrome. Oral Surg Oral Med Oral Pathol 35:302-328.

23.

Pruzansky

(1969). Not all dwarfed mandibles are alike. Birth Defects 5:120-129.

24.

Seow

Urban

Vafaie

Shusterman

(1998). Morphometric analysis of the primary and permanent dentitions in hemifacial microsomia: a controlled study. J Dent Res 77:27-38.

25.

Shafer

Hine

Levy

(1983). Textbook of oral pathology. 4th ed. Philadelphia, PA: W.B. Saunders and Company.

26.

Silvestri

Natali

Fadda

(1996). Dental agenesis in hemifacial microsomia. Pediatr Dent 18:48-51.

27.

Thesleff

(2006). The genetic basis of tooth development and dental defects. Am J Med Genet A 140:2530-2535.